Anca Radauceanu1, Michel Grzebyk2, Jean-Louis Edmé3, Nathalie Chérot-Kornobis4, Davy Rousset5, Mathieu Dziurla6, Virginie De Broucker7, Guy Hédelin8, Annie Sobaszek9, Sébastien Hulo10. 1. Institut National de Recherche et de Sécurité pour la prévention des accidents de travail et des maladies professionnelles (INRS) : 1, rue du Morvan, CS 60027, 54519Vandœuvre-lès-Nancy Cedex, France. Electronic address: anca.radauceanu@inrs.fr. 2. Institut National de Recherche et de Sécurité pour la prévention des accidents de travail et des maladies professionnelles (INRS) : 1, rue du Morvan, CS 60027, 54519Vandœuvre-lès-Nancy Cedex, France. Electronic address: michel.grzebyk@inrs.fr. 3. Université de Lille, EA 4483 : 1, place de Verdun, 59045 Lille, France; Centre Hospitalier Universitaire de Lille, Service des Explorations Fonctionnelles Respiratoires : 2, avenue Oscar Lambret, 59037 Lille Cedex, France. Electronic address: jledme@univ-lille2.fr. 4. Université de Lille, EA 4483 : 1, place de Verdun, 59045 Lille, France; Centre Hospitalier Universitaire de Lille, Service de Médecine du Travail du Personnel Hospitalier : 2, avenue Oscar Lambret, 59037 Lille Cedex, France. Electronic address: nathalie.cherot@univ-lille2.fr. 5. Institut National de Recherche et de Sécurité pour la prévention des accidents de travail et des maladies professionnelles (INRS) : 1, rue du Morvan, CS 60027, 54519Vandœuvre-lès-Nancy Cedex, France. Electronic address: davy.rousset@inrs.fr. 6. Institut National de Recherche et de Sécurité pour la prévention des accidents de travail et des maladies professionnelles (INRS) : 1, rue du Morvan, CS 60027, 54519Vandœuvre-lès-Nancy Cedex, France. Electronic address: mathieu.dziurla@inrs.fr. 7. Université de Lille, EA 4483 : 1, place de Verdun, 59045 Lille, France; Centre Hospitalier Universitaire de Lille, Service des Explorations Fonctionnelles Respiratoires : 2, avenue Oscar Lambret, 59037 Lille Cedex, France. Electronic address: virginie.debroucker@chru-lille.fr. 8. Institut National de Recherche et de Sécurité pour la prévention des accidents de travail et des maladies professionnelles (INRS) : 1, rue du Morvan, CS 60027, 54519Vandœuvre-lès-Nancy Cedex, France. Electronic address: guy.hedelin@inrs.fr. 9. Université de Lille, EA 4483 : 1, place de Verdun, 59045 Lille, France; Centre Hospitalier Universitaire de Lille, Service de Médecine du Travail du Personnel Hospitalier : 2, avenue Oscar Lambret, 59037 Lille Cedex, France. Electronic address: annie.sobaszek@univ-lille2.fr. 10. Université de Lille, EA 4483 : 1, place de Verdun, 59045 Lille, France; Centre Hospitalier Universitaire de Lille, Service des Explorations Fonctionnelles Respiratoires : 2, avenue Oscar Lambret, 59037 Lille Cedex, France. Electronic address: sebastien.hulo@univ-lille2.fr.
Abstract
OBJECTIVE: To analyze the effects of occupational exposure to poorly soluble forms of beryllium (Be) on biomarkers of pulmonary inflammation using exhaled breath condensate (EBC) in workers employed in machining industries. METHODS: Twenty machining operators were compared to 16 controls. The individual exposure to Be was assessed from the work history with several indices of exposure calculated on the basis of task-exposures matrices developed for each plant using historical air measurements. Clinical evaluation consisted in a medical questionnaire, measurements of biomarkers in EBC (tumor necrosis factor alpha (TNF-α), total nitrogen oxides (NOx)), measurement of the fraction of exhaled nitric oxide (FeNO) and resting spirometry. Adjusted multiple linear regressions were used to study the effect of the exposure to Be on inflammatory biomarkers. RESULTS: Levels of TNF-α and NOx in EBC were not statistically different between exposed and controls. We found a statistically significant relationship between levels of TNF-α in EBC and both index of cumulative exposure and duration of exposure to Be. No other statistically significant relationships were found between exposure to Be and pulmonary response. CONCLUSION: Our results suggest that machining-related exposure to Be is related to pulmonary inflammation involving TNF-α. These findings must be confirmed by larger studies. Copyright Â
OBJECTIVE: To analyze the effects of occupational exposure to poorly soluble forms of beryllium (Be) on biomarkers of pulmonary inflammation using exhaled breath condensate (EBC) in workers employed in machining industries. METHODS: Twenty machining operators were compared to 16 controls. The individual exposure to Be was assessed from the work history with several indices of exposure calculated on the basis of task-exposures matrices developed for each plant using historical air measurements. Clinical evaluation consisted in a medical questionnaire, measurements of biomarkers in EBC (tumor necrosis factor alpha (TNF-α), total nitrogen oxides (NOx)), measurement of the fraction of exhaled nitric oxide (FeNO) and resting spirometry. Adjusted multiple linear regressions were used to study the effect of the exposure to Be on inflammatory biomarkers. RESULTS: Levels of TNF-α and NOx in EBC were not statistically different between exposed and controls. We found a statistically significant relationship between levels of TNF-α in EBC and both index of cumulative exposure and duration of exposure to Be. No other statistically significant relationships were found between exposure to Be and pulmonary response. CONCLUSION: Our results suggest that machining-related exposure to Be is related to pulmonary inflammation involving TNF-α. These findings must be confirmed by larger studies. Copyright Â
Authors: Anjoeka Pronk; Miranda Loh; Eelco Kuijpers; Maria Albin; Jenny Selander; Lode Godderis; Manosij Ghosh; Roel Vermeulen; Susan Peters; Ingrid Sivesind Mehlum; Michelle C Turner; Vivi Schlünssen; Marcel Goldberg; Manolis Kogevinas; Barbara N Harding; Svetlana Solovieva; Tina Garani-Papadatos; Martie van Tongeren; Rob Stierum Journal: Environ Epidemiol Date: 2022-02-17