Literature DB >> 27776973

PLC-β1 and cell differentiation: An insight into myogenesis and osteogenesis.

Giulia Ramazzotti1, Irene Faenza2, Roberta Fiume2, Anna Maria Billi2, Lucia Manzoli2, Sara Mongiorgi2, Stefano Ratti2, James A McCubrey3, Pann-Ghill Suh4, Lucio Cocco2, Matilde Y Follo2.   

Abstract

Phosphoinositide-phospholipase C-β1 (PLC-β1) plays a crucial role in the initiation of the genetic program responsible for muscle differentiation and osteogenesis. During myogenic differentiation of murine C2C12 myoblasts, PLC-β1 signaling pathway involves the Inositol Polyphosphate Multikinase (IPMK) and β-catenin as downstream effectors. By means of c-jun binding to cyclin D3 promoter, the activation of PLC-β1 pathway determines cyclin D3 accumulation. However, osteogenesis requires PLC-β1 expression and up-regulation but it does not affect cyclin D3 levels, suggesting that the two processes require the activation of different mediators.
Copyright © 2016 Elsevier Ltd. All rights reserved.

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Year:  2016        PMID： 27776973     DOI： 10.1016/j.jbior.2016.10.005

Source DB:  PubMed          Journal:  Adv Biol Regul        ISSN： 2212-4926


  10 in total

1.  Phospholipase C delta 4 (PLCδ4) is a nuclear protein involved in cell proliferation and senescence in mesenchymal stromal stem cells.

Authors:  Marianna Kunrath-Lima; Marcelo Coutinho de Miranda; Andrea da Fonseca Ferreira; Camila Cristina Fraga Faraco; Mariane Izabella Abreu de Melo; Alfredo Miranda Goes; Michele Angela Rodrigues; Jerusa Araújo Quintão Arantes Faria; Dawidson Assis Gomes
Journal:  Cell Signal       Date:  2018-06-01       Impact factor: 4.315

Review 2.  Phospholipase Cβ interacts with cytosolic partners to regulate cell proliferation.

Authors:  Suzanne Scarlata; Ashima Singla; Osama Garwain
Journal:  Adv Biol Regul       Date:  2017-09-09

Review 3.  Nuclear phospholipase C isoenzyme imbalance leads to pathologies in brain, hematologic, neuromuscular, and fertility disorders.

Authors:  Stefano Ratti; Matilde Y Follo; Giulia Ramazzotti; Irene Faenza; Roberta Fiume; Pann-Ghill Suh; James A McCubrey; Lucia Manzoli; Lucio Cocco
Journal:  J Lipid Res       Date:  2018-10-04       Impact factor: 5.922

4.  Structural features of human inositol phosphate multikinase rationalize its inositol phosphate kinase and phosphoinositide 3-kinase activities.

Authors:  Huanchen Wang; Stephen B Shears
Journal:  J Biol Chem       Date:  2017-09-07       Impact factor: 5.157

Review 5.  "Modulating Phosphoinositide Profiles as a Roadmap for Treatment in Acute Myeloid Leukemia".

Authors:  Stefano Ratti; Camilla Evangelisti; Sara Mongiorgi; Alessia De Stefano; Antonietta Fazio; Francesca Bonomini; Matilde Y Follo; Irene Faenza; Lucia Manzoli; Bhavwanti Sheth; Magdalena C Vidalle; Scott T Kimber; Nullin Divecha; Lucio Cocco; Roberta Fiume
Journal:  Front Oncol       Date:  2021-05-24       Impact factor: 6.244

6.  Knockdown of subunit 3 of the COP9 signalosome inhibits C2C12 myoblast differentiation via NF-KappaB signaling pathway.

Authors:  Mariam A Ba; Jeffrey Surina; Cherie A Singer; Maria L Valencik
Journal:  BMC Pharmacol Toxicol       Date:  2017-06-17       Impact factor: 2.483

Review 7.  The Expanding Significance of Inositol Polyphosphate Multikinase as a Signaling Hub.

Authors:  Eunha Kim; Hyoungjoon Ahn; Min Gyu Kim; Haein Lee; Seyun Kim
Journal:  Mol Cells       Date:  2017-05-29       Impact factor: 5.034

Review 8.  Phosphoinositide-Dependent Signaling in Cancer: A Focus on Phospholipase C Isozymes.

Authors:  Eric Owusu Obeng; Isabella Rusciano; Maria Vittoria Marvi; Antonietta Fazio; Stefano Ratti; Matilde Yung Follo; Jie Xian; Lucia Manzoli; Anna Maria Billi; Sara Mongiorgi; Giulia Ramazzotti; Lucio Cocco
Journal:  Int J Mol Sci       Date:  2020-04-08       Impact factor: 5.923

9.  Pharmic Activation of PKG2 Alleviates Diabetes-Induced Osteoblast Dysfunction by Suppressing PLCβ1-Ca2+-Mediated Endoplasmic Reticulum Stress.

Authors:  Tingting Jia; Ya-Nan Wang; Yao Feng; Chenchen Wang; Dongjiao Zhang; Xin Xu
Journal:  Oxid Med Cell Longev       Date:  2021-06-16       Impact factor: 6.543

Review 10.  Nuclear Inositides and Inositide-Dependent Signaling Pathways in Myelodysplastic Syndromes.

Authors:  Jie Xian; Eric Owusu Obeng; Stefano Ratti; Isabella Rusciano; Maria Vittoria Marvi; Antonietta Fazio; Alessia De Stefano; Sara Mongiorgi; Alessandra Cappellini; Giulia Ramazzotti; Lucia Manzoli; Lucio Cocco; Matilde Yung Follo
Journal:  Cells       Date:  2020-03-12       Impact factor: 6.600
  10 in total

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