Agnieszka Ciarka1, Leah Edwards2, Johan Nilsson3, Josef Stehlik4, Lars H Lund5. 1. Department of Cardiovascular Diseases, University Hospitals Leuven, Herestraat 49, B-3000 Leuven, Belgium. Electronic address: Agnieszka.Ciarka@uzleuven.be. 2. United Network for Organ Sharing (UNOS), Richmond, US. 3. Cardiology Department, Lund University, Sweden. 4. Division of Cardiovascular Medicine, University of Utah School of Medicine, Salt Lake City, UT, USA. 5. Department of Medicine, Karolinska Institutet, and Department of Cardiology, Karolinska University Hospital, Stockholm, Sweden.
Abstract
INTRODUCTION: Numerous cohort analyses suggest rapidly increasing use of mechanical circulatory support (MCS) as a bridge to heart transplantation (HTx), but the role of age in selection for MCS remains unknown. METHODS: We assessed adult HTx in the International Society for Heart And Lung Transplantation Registry between 2005 and 2013 and we determined MCS use by recipient age group and transplant year. Multivariable logistic regression models were constructed to identify variables associated with continuous flow (CF) left ventricular assist device (LVAD) use within each age group. RESULTS: Among 16,480 HTx recipients the percentage of overall MCS use increased from 23% to 38%, 21% to 41%, and 17% to 42% in age groups 18-39 years, 40-59 years and over 60 years, respectively. This effect was mainly due to an increase in CF LVAD use and primarily in HTx recipients aged over 60. In multivariable analyses, male gender and blood group O were significantly associated with CF LVAD use in all age groups. CONCLUSIONS: Bridge to transplant MCS use increased dramatically between 2005 and 2013 primarily due to increased use of CF LVAD and primarily in higher ages. Pre-HTx CF LVAD use was more frequent in men and blood group O.
INTRODUCTION: Numerous cohort analyses suggest rapidly increasing use of mechanical circulatory support (MCS) as a bridge to heart transplantation (HTx), but the role of age in selection for MCS remains unknown. METHODS: We assessed adult HTx in the International Society for Heart And Lung Transplantation Registry between 2005 and 2013 and we determined MCS use by recipient age group and transplant year. Multivariable logistic regression models were constructed to identify variables associated with continuous flow (CF) left ventricular assist device (LVAD) use within each age group. RESULTS: Among 16,480 HTx recipients the percentage of overall MCS use increased from 23% to 38%, 21% to 41%, and 17% to 42% in age groups 18-39 years, 40-59 years and over 60 years, respectively. This effect was mainly due to an increase in CF LVAD use and primarily in HTx recipients aged over 60. In multivariable analyses, male gender and blood group O were significantly associated with CF LVAD use in all age groups. CONCLUSIONS: Bridge to transplant MCS use increased dramatically between 2005 and 2013 primarily due to increased use of CF LVAD and primarily in higher ages. Pre-HTx CF LVAD use was more frequent in men and blood group O.
Authors: Nisha Bansal; Susan M Hailpern; Ronit Katz; Yoshio N Hall; Manjula Kurella Tamura; William Kreuter; Ann M O'Hare Journal: JAMA Intern Med Date: 2018-02-01 Impact factor: 21.873
Authors: Juan Diego Sánchez Vega; Gonzalo Luis Alonso Salinas; José María Viéitez Florez; Albert Ariza Solé; Esteban López de Sá; Ricardo Sanz-Ruiz; Virginia Burgos Palacios; Sergio Raposeiras Roubin; Susana Gómez Varela; Juan Sanchís Forés; Lorenzo Silva Melchor; Xurxo Martínez-Seara; Lorena Malagón López; Ana Viana Tejedor; Miguel Corbí Pascual; José Luis Zamorano Gómez; Marcelo Sanmartín-Fernández Journal: Cardiol J Date: 2022-05-17 Impact factor: 3.487