Familial occurrence of cancer and heteromorphism of the heterochromatic segment of chromosome 1.

During the last decade, evidence has been forthcoming in support of the correlation between heteromorphism of human chromosome 1qh and the incidence of various malignancies in the carriers of such heteromorphism. We present data from a family with hereditary predisposition to cancer. In this family, five members in a sibship of seven developed ovary and/or colon carcinoma at comparatively young ages. A further 4 cases of malignant disease were ascertained, when a pedigree of 36 family members of 3 generations was constructed. Chromosome analysis was carried out in G- and C-banding from peripheral blood cultures of 19 family members. Distinct heteromorphism in the chromosome 1qh region was detected in 15 (79%) of them, including all 3 cancer patients investigated.