PURPOSE: Prediabetes is linked to several modifiable risk factors, in particular, physical activity participation. The optimal prescription for physical activity remains uncertain. This pilot study aimed to investigate the effectiveness of continuous moderate intensity (CON) versus high-intensity interval training (HIIT) in persons with prediabetes. Outcome measures included glycated hemoglobin (A1C), body composition, musculoskeletal and aerobic fitness. METHODS:Participants (n = 35) were recruited and screened using a questionnaire plus capillary blood point-of-care A1C analysis. After baseline screening/exclusions, 21 participants were randomly assigned to either HIIT or CON training three times per week for 12 wk. All participants also undertook resistance training two times per week. A1C, an oral glucose tolerance test, select measures of physical and physiological fitness were assessed at baseline and follow-up. RESULTS: There were no significant differences in improvements in select metabolic indicators to training between CON and HIT groups. Pooled participant data showed a mean reduction in A1C of 0.5% (95% confidence interval [CI] = 0.3%-0.7%), whereas β-cell function (%β) improved by 28.9% (95% CI = 16.5%-39.2%) and insulin sensitivity (%S) decreased by 34.8 (95% CI = 57.8%-11.8), as assessed by the Homeostatic Model Assessment. Significant reductions in waist circumference of 4.5 cm (P < 0.001) and a 20% (P < 0.001) improvement in aerobic fitness were also observed in both training groups. CONCLUSION: The completion of a 12-wk exercise program involving both resistance training and either HIIT or CON training results in improved glycemic control, visceral adiposity, and aerobic fitness in persons with prediabetes.
RCT Entities:
PURPOSE:Prediabetes is linked to several modifiable risk factors, in particular, physical activity participation. The optimal prescription for physical activity remains uncertain. This pilot study aimed to investigate the effectiveness of continuous moderate intensity (CON) versus high-intensity interval training (HIIT) in persons with prediabetes. Outcome measures included glycated hemoglobin (A1C), body composition, musculoskeletal and aerobic fitness. METHODS:Participants (n = 35) were recruited and screened using a questionnaire plus capillary blood point-of-care A1C analysis. After baseline screening/exclusions, 21 participants were randomly assigned to either HIIT or CON training three times per week for 12 wk. All participants also undertook resistance training two times per week. A1C, an oral glucose tolerance test, select measures of physical and physiological fitness were assessed at baseline and follow-up. RESULTS: There were no significant differences in improvements in select metabolic indicators to training between CON and HIT groups. Pooled participant data showed a mean reduction in A1C of 0.5% (95% confidence interval [CI] = 0.3%-0.7%), whereas β-cell function (%β) improved by 28.9% (95% CI = 16.5%-39.2%) and insulin sensitivity (%S) decreased by 34.8 (95% CI = 57.8%-11.8), as assessed by the Homeostatic Model Assessment. Significant reductions in waist circumference of 4.5 cm (P < 0.001) and a 20% (P < 0.001) improvement in aerobic fitness were also observed in both training groups. CONCLUSION: The completion of a 12-wk exercise program involving both resistance training and either HIIT or CON training results in improved glycemic control, visceral adiposity, and aerobic fitness in persons with prediabetes.
Authors: Rachael S Allen; Adam M Hanif; Marissa A Gogniat; Brian C Prall; Raza Haider; Moe H Aung; Megan C Prunty; Lukas M Mees; Monica M Coulter; Cara T Motz; Jeffrey H Boatright; Machelle T Pardue Journal: Eur J Neurosci Date: 2018-04-03 Impact factor: 3.386
Authors: Aleksandra Żebrowska; Marcin Sikora; Anna Konarska; Anna Zwierzchowska; Tomasz Kamiński; Anna Robins; Barbara Hall Journal: Ther Adv Endocrinol Metab Date: 2020-05-27 Impact factor: 3.565
Authors: Sanjay Kalra; Abhay Sahoo; Sambit Das; K V S Hari Kumar; Anoj Kumar Baliarsinha; Binoy Mohanty; Jayabhanu Kanwar; Sunil Kota; Sudeep Satpathy; Muthukrishnan Jayaraman; S K Singh; S V Madhu; Mona Shah; Narendra Kotwal; Gagan Priya; Belinda George; Arundhati Dasgupta; Arun Kumar R Pande; Nikhil Latey; Puneet Dhamija; John Ayuk; David Torpy; Pankaj Shah; Mohammed Wali Naseri; Robin Maskey; Zafar A Latif; Noel Somasundaram; Ali Jawa; Kirtida Acharya Journal: Indian J Endocrinol Metab Date: 2018-11
Authors: André L L Bachi; Marcelo P Barros; Rodolfo P Vieira; Gislene A Rocha; Paula B M de Andrade; Angélica B Victorino; Luiz R Ramos; Claudia F Gravina; José D Lopes; Mauro Vaisberg; Raul C Maranhão Journal: Oxid Med Cell Longev Date: 2019-08-05 Impact factor: 6.543