X Liu1, X F Sun, Q X Ge. 1. Department of Gastroenterology, Henan University Huaihe Hospital, Kaifeng, Henan, China. liuxin26@126.com.
Abstract
OBJECTIVE: To evaluate the role of glutamine-supplemented total parenteral nutrition (TPN) in severe acute pancreatitis. PATIENTS AND METHODS: Forty-seven patients with severe acute pancreatitis were admitted to Huaihe Hospital, China, over a period of one year (July 2013 to June 2014) were randomly divided into two therapeutic groups. Patients in group 1 (24 patients in total) and group 2 (23 patient in total) were treated with glutamine-supplemented TPN and standard TPN respectively. Patients were assessed for nutritional parameters, the prevalence of complications, mortality, length of hospital stay (LOS) and length of TPN. RESULTS: The majority of patients were male in both groups (62.5% in group 1 and 60.9% in group 2) and the average age was similar (39.13±4.46 years in group 1 and 40±3.96 years in group 2). The major causative factor was also similar in both groups, i.e. gall stones. The prevalence of complications in the group 2 was much higher (47.85%) than those in the group 1 (25%). The mortality rate for group 1 and 2 were 4.2% (1/24) and 17.4% (4/23), respectively. The length of hospital stay in the group 2 (23.08 ± 2.02 days) was longer than those of the group 1 (20.33 ± 2.40 days). The length of TPN was also longer in the group 2 (16.47 ± 2.72 days) than those of the group 1 (10.56 ± 2.21 days). Glutamine was also associated with significant increase in serum albumin level. CONCLUSIONS:Glutamine-supplemented TPN can reduce the mortality and the occurrence of complications, shorten the length of stay and improve the nutritional status of the patients with severe acute pancreatitis.
RCT Entities:
OBJECTIVE: To evaluate the role of glutamine-supplemented total parenteral nutrition (TPN) in severe acute pancreatitis. PATIENTS AND METHODS: Forty-seven patients with severe acute pancreatitis were admitted to Huaihe Hospital, China, over a period of one year (July 2013 to June 2014) were randomly divided into two therapeutic groups. Patients in group 1 (24 patients in total) and group 2 (23 patient in total) were treated with glutamine-supplemented TPN and standard TPN respectively. Patients were assessed for nutritional parameters, the prevalence of complications, mortality, length of hospital stay (LOS) and length of TPN. RESULTS: The majority of patients were male in both groups (62.5% in group 1 and 60.9% in group 2) and the average age was similar (39.13±4.46 years in group 1 and 40±3.96 years in group 2). The major causative factor was also similar in both groups, i.e. gall stones. The prevalence of complications in the group 2 was much higher (47.85%) than those in the group 1 (25%). The mortality rate for group 1 and 2 were 4.2% (1/24) and 17.4% (4/23), respectively. The length of hospital stay in the group 2 (23.08 ± 2.02 days) was longer than those of the group 1 (20.33 ± 2.40 days). The length of TPN was also longer in the group 2 (16.47 ± 2.72 days) than those of the group 1 (10.56 ± 2.21 days). Glutamine was also associated with significant increase in serum albumin level. CONCLUSIONS:Glutamine-supplemented TPN can reduce the mortality and the occurrence of complications, shorten the length of stay and improve the nutritional status of the patients with severe acute pancreatitis.