| Literature DB >> 27775720 |
Sandra Goebbels1, Georg L Wieser1, Alexander Pieper1, Sonia Spitzer2, Bettina Weege1, Kuo Yan3, Julia M Edgar1, Oleksandr Yagensky1, Sven P Wichert1, Amit Agarwal1, Khalad Karram4, Nicolas Renier5, Marc Tessier-Lavigne5, Moritz J Rossner1, Ragnhildur Thóra Káradóttir2, Klaus-Armin Nave1.
Abstract
The molecular trigger of CNS myelination is unknown. By targeting Pten in cerebellar granule cells and activating the AKT1-mTOR pathway, we increased the caliber of normally unmyelinated axons and the expression of numerous genes encoding regulatory proteins. This led to the expansion of genetically wild-type oligodendrocyte progenitor cells, oligodendrocyte differentiation and de novo myelination of parallel fibers. Thus, a neuronal program dependent on the phosphoinositide PI(3,4,5)P3 is sufficient to trigger all steps of myelination.Entities:
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Year: 2016 PMID： 27775720 DOI： 10.1038/nn.4425
Source DB: PubMed Journal: Nat Neurosci ISSN： 1097-6256 Impact factor: 24.884