| Literature DB >> 27772704 |
Hongjie Chen1, Chunli Wang1, Xiao Yang1, Zhanwen Xiao1, Xiangdong Zhu2, Kai Zhang1, Yujiang Fan1, Xingdong Zhang3.
Abstract
A simple approach to fabricating hydroxyxapatite/titanium dioxide (HA/TiO2) coating on porous titanium (Ti) scaffolds was developed in the present study. Surface TiO2 layer was firstly formed on porous Ti scaffolds with multi-scale pores by acid-alkali (AA) treatment. The outer HA layer was then formed on the TiO2 layer by subsequent pulse electrochemical deposition (ED) technique. All the three main process parameters, i.e. deposition times, current density and mass transfer mode affected the properties of the HA coating notably. Under the conditions of 90 deposition cycles, -10mA/cm2 of pulse current density and stirring, a thin layer of homogeneous and nanorod-like HA sediments was formed on the substrate surface of porous Ti scaffolds. The results of protein adsorption and cellular experiments showed that compared to the single TiO2 surface, the HA/TiO2 surface allowed more adsorption of serum proteins and further enhanced the alkaline phosphatase (ALP) activity of MC3T3-E1 osteoblasts.Entities:
Keywords: Electrochemical deposition; HA/TiO(2) coating; Osteoblasts; Porous titanium; Protein adsorption
Mesh：
Substances：
Year: 2016 PMID： 27772704 DOI： 10.1016/j.msec.2016.04.013
Source DB: PubMed Journal: Mater Sci Eng C Mater Biol Appl ISSN： 0928-4931 Impact factor: 7.328