Literature DB >> 2777258

Linkage disequilibrium for DNA haplotypes near the cystic fibrosis locus in two south European populations.

X Estivill1, P Gasparini, G Novelli, T Casals, V Nunes, P Gallano, A Savoia, A Ruzzo, B Dallapiccola, P F Pignatti.   

Abstract

Three polymorphic DNA marker loci (INT1L1, D7S23 and D7S399) map to a chromosomal region that is very close to the cystic fibrosis (CF) locus in terms of genetic distance. These marker loci have been used to analyse the linkage disequilibrium in 137 CF families from two South European countries (Italy and Spain). The markers can be analysed for differences in linkage disequilibrium more easily in these populations than in North Europeans, in whom the disequilibrium between the allelic systems defined by the probes and CF is much greater and on a "plateau" through the genetic region. The different levels of disequilibrium found in the studied populations suggest that D7S399 and D7S23 are both closer to CF than INT1L1, and provide additional information on the origins and homogeneity of the CF defect.

Entities:  

Mesh:

Substances:

Year:  1989        PMID: 2777258     DOI: 10.1007/BF00286713

Source DB:  PubMed          Journal:  Hum Genet        ISSN: 0340-6717            Impact factor:   4.132


  20 in total

1.  Recombinations between IRP and cystic fibrosis.

Authors:  M Farrall; B J Wainwright; G L Feldman; A Beaudet; Z Sretenovic; D Halley; M Simon; L Dickerman; M Devoto; G Romeo
Journal:  Am J Hum Genet       Date:  1988-10       Impact factor: 11.025

2.  A polymorphic DNA marker linked to cystic fibrosis is located on chromosome 7.

Authors:  R G Knowlton; O Cohen-Haguenauer; N Van Cong; J Frézal; V A Brown; D Barker; J C Braman; J W Schumm; L C Tsui; M Buchwald
Journal:  Nature       Date:  1985 Nov 28-Dec 4       Impact factor: 49.962

3.  Experience with new DNA markers for the diagnosis of cystic fibrosis.

Authors:  A L Beaudet; J E Spence; M Montes; W E O'Brien; X Estivill; M Farrall; R Williamson
Journal:  N Engl J Med       Date:  1988-01-07       Impact factor: 91.245

4.  Isolation of a further anonymous informative DNA sequence from chromosome seven closely linked to cystic fibrosis.

Authors:  P J Scambler; B J Wainwright; E Watson; G Bates; G Bell; R Williamson; M Farrall
Journal:  Nucleic Acids Res       Date:  1986-03-11       Impact factor: 16.971

5.  Patterns of polymorphism and linkage disequilibrium for cystic fibrosis.

Authors:  X Estivill; P J Scambler; B J Wainwright; K Hawley; P Frederick; M Schwartz; M Baiget; J Kere; R Williamson; M Farrall
Journal:  Genomics       Date:  1987-11       Impact factor: 5.736

6.  A candidate for the cystic fibrosis locus isolated by selection for methylation-free islands.

Authors:  X Estivill; M Farrall; P J Scambler; G M Bell; K M Hawley; N J Lench; G P Bates; H C Kruyer; P A Frederick; P Stanier
Journal:  Nature       Date:  1987 Apr 30-May 6       Impact factor: 49.962

7.  Chromosome assignment and restriction fragment length polymorphism analysis of the anonymous DNA probe B79a at 7q22 (HMG8 assignment D7S13).

Authors:  X Estivill; J Schmidtke; R Williamson; B Wainwright
Journal:  Hum Genet       Date:  1986-11       Impact factor: 4.132

8.  "A technique for radiolabeling DNA restriction endonuclease fragments to high specific activity". Addendum.

Authors:  A P Feinberg; B Vogelstein
Journal:  Anal Biochem       Date:  1984-02       Impact factor: 3.365

9.  Cystic fibrosis locus defined by a genetically linked polymorphic DNA marker.

Authors:  L C Tsui; M Buchwald; D Barker; J C Braman; R Knowlton; J W Schumm; H Eiberg; J Mohr; D Kennedy; N Plavsic
Journal:  Science       Date:  1985-11-29       Impact factor: 47.728

10.  Localization of cystic fibrosis locus to human chromosome 7cen-q22.

Authors:  B J Wainwright; P J Scambler; J Schmidtke; E A Watson; H Y Law; M Farrall; H J Cooke; H Eiberg; R Williamson
Journal:  Nature       Date:  1985 Nov 28-Dec 4       Impact factor: 49.962

View more
  5 in total

1.  Gradient of distribution in Europe of the major CF mutation and of its associated haplotype. European Working Group on CF Genetics (EWGCFG).

Authors: 
Journal:  Hum Genet       Date:  1990-09       Impact factor: 4.132

2.  Discrimination between recurrent mutation and identity by descent: application to point mutations in exon 11 of the cystic fibrosis (CFTR) gene.

Authors:  J Reiss; D N Cooper; J Bal; R Slomski; G R Cutting; M Krawczak
Journal:  Hum Genet       Date:  1991-08       Impact factor: 4.132

3.  Pancreatic function and gene deletion F508 in cystic fibrosis.

Authors:  G Borgo; G Mastella; P Gasparini; A Zorzanello; R Doro; P F Pignatti
Journal:  J Med Genet       Date:  1990-11       Impact factor: 6.318

4.  A fertile male with cystic fibrosis: molecular genetic analysis.

Authors:  C Barreto; L M Pinto; A Duarte; J Lavinha; M Ramsay
Journal:  J Med Genet       Date:  1991-06       Impact factor: 6.318

5.  The genotype of a new linked DNA marker, MP6d-9, is related to the clinical course of cystic fibrosis.

Authors:  P Gasparini; G Novelli; X Estivill; D Olivieri; A Savoia; A Ruzzo; V Nunes; G Borgo; M Antonelli; R Williamson
Journal:  J Med Genet       Date:  1990-01       Impact factor: 6.318

  5 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.