Elena Milla1,2, Oana Stirbu3, Isabel Jimenez Franco4, Santiago J García Hernández4, Jose Rios5, Susana Duch3. 1. Glaucoma Unit, Ophthalmology Department, Hospital Clínic de Barcelona, Sabino Arana, 1, 08028, Barcelona, Spain. millagrinoelena@gmail.com. 2. Glaucoma Unit, Institut Comtal d'Oftalmologia, Barcelona, Spain. millagrinoelena@gmail.com. 3. Glaucoma Unit, Institut Comtal d'Oftalmologia, Barcelona, Spain. 4. Glaucoma Unit, Ophthalmology Department, Complejo Asistencial Universitario de Salamanca, Salamanca, Spain. 5. Statistics Department, Hospital Clinic, Barcelona, Spain.
Abstract
PURPOSE: Retrospective, pilot study to determine whether nepafenac treatment pre- and postcataract surgery in glaucoma patients using topical hypotensive agents minimized cystoid macular edema by comparing pre- and postsurgical foveal characteristics, as in some cases these agents cannot be withdrawn and, hypothetically, their inflammatory effect on the fovea could be neutralized by the addition of nepafenac. METHODS: Patients were divided into two subgroups depending on whether or not topical nepafenac was added to the surgical protocol (NEP = nepafenac group and nNEP = non nepafenac group). All had undergone phacoemulsification and data on pre- and postoperative macular status were recorded. RESULTS: In the nNEP group, there was a significant increase in foveal thickness (FT) in the first month postoperative visit with respect to the preoperative status (p = 0.006), and this situation did not change at the third postoperative month (p = 0.9411). In the NEP group, the increase in FT was not significant at the first month after surgery (p = 0.056) nor at the final visit (p = 0.268), in contrast to the nNEP group. CONCLUSION: This study of the possible prophylactic effect of nepafenac on postoperative macular edema supports the results of other studies that confirm subclinical edema post phacoemulsification, and found a significantly lower gradient in the increase in FT in patients treated pre- and postoperatively with nepafenac.
PURPOSE: Retrospective, pilot study to determine whether nepafenac treatment pre- and postcataract surgery in glaucomapatients using topical hypotensive agents minimized cystoid macular edema by comparing pre- and postsurgical foveal characteristics, as in some cases these agents cannot be withdrawn and, hypothetically, their inflammatory effect on the fovea could be neutralized by the addition of nepafenac. METHODS:Patients were divided into two subgroups depending on whether or not topical nepafenac was added to the surgical protocol (NEP = nepafenac group and nNEP = non nepafenac group). All had undergone phacoemulsification and data on pre- and postoperative macular status were recorded. RESULTS: In the nNEP group, there was a significant increase in foveal thickness (FT) in the first month postoperative visit with respect to the preoperative status (p = 0.006), and this situation did not change at the third postoperative month (p = 0.9411). In the NEP group, the increase in FT was not significant at the first month after surgery (p = 0.056) nor at the final visit (p = 0.268), in contrast to the nNEP group. CONCLUSION: This study of the possible prophylactic effect of nepafenac on postoperative macular edema supports the results of other studies that confirm subclinical edema post phacoemulsification, and found a significantly lower gradient in the increase in FT in patients treated pre- and postoperatively with nepafenac.
Authors: S E Moroi; M S Gottfredsdottir; M T Schteingart; S G Elner; C M Lee; R M Schertzer; G W Abrams; M W Johnson Journal: Ophthalmology Date: 1999-05 Impact factor: 12.079