P Monica Lind1, Samira Salihovic2, Bert van Bavel3, Lars Lind4. 1. Department of Medical Sciences, Occupational and Environmental Medicine, Uppsala University Uppsala, Sweden. Electronic address: monica.lind@medsci.uu.se. 2. Department of Medical Sciences, Molecular Epidemiology and Science for Life Laboratory, Uppsala University, Uppsala, Sweden; MTM Research Centre, School of Science and Technology, Örebro University, Örebro, Sweden. Electronic address: samira.salihovic@medsci.uu.se. 3. MTM Research Centre, School of Science and Technology, Örebro University, Örebro, Sweden. Electronic address: bert.vanbavel@oru.se. 4. Department of Medical Sciences, Cardiovascular Epidemiology, Uppsala University, Uppsala, Sweden. Electronic address: lars.lind@medsci.uu.se.
Abstract
BACKGROUND AND OBJECTIVE: During recent years, some persistent organic pollutants (POPs) have been linked to atherosclerosis. One group of POPs, the poly- and perfluoroalkyl substances (PFASs) have not been investigated with regard to atherosclerotic plaques. METHODS: Carotid artery atherosclerosis was assessed by ultrasound in 1016 subjects aged 70 years in the Prospective Investigation of the Vasculature in Uppsala Seniors (PIVUS) study. Eight PFASs were detected in >75% of participants' plasma by ultra-performance liquid chromatography coupled to tandem mass spectrometry (UPLC-MS/MS). RESULTS: No significant linear associations were observed between the PFASs and intima-media thickness (IMT), or the echogenicity in the intima-media complex (IM-GSM, a marker of lipid infiltration in the artery) when men and women were analyzed together. Neither was occurrence of carotid plaques related to PFASs levels. However, highly significant interactions were observed between some PFASs and sex regarding both IM-GSM and plaque prevalence. Perfluorononanoic acid (PFNA), perfluorodecanoic acid (PFDA), and perfluoroundecanoic acid (PFUnDA), were all related to IM-GSM in a positive fashion in women (p=0.002-0.003), while these relationships were negative in men. The levels of PFUnDA were significantly related to carotid plaque in women (OR 1.59, 95%CI 1.03-2.43, p=0.03), but not in men (OR 0.93, 95%CI 0.62-1.42, p=0.75). CONCLUSIONS: In this cross-sectional study, a pronounced gender difference was observed regarding associations between some PFASs, especially the long-chain PFUnDA, and markers of atherosclerosis, with more pronounced relationships found in women. These findings suggest a sex-specific role for PFASs in atherosclerosis. Copyright Â
BACKGROUND AND OBJECTIVE: During recent years, some persistent organic pollutants (POPs) have been linked to atherosclerosis. One group of POPs, the poly- and perfluoroalkyl substances (PFASs) have not been investigated with regard to atherosclerotic plaques. METHODS:Carotid artery atherosclerosis was assessed by ultrasound in 1016 subjects aged 70 years in the Prospective Investigation of the Vasculature in Uppsala Seniors (PIVUS) study. Eight PFASs were detected in >75% of participants' plasma by ultra-performance liquid chromatography coupled to tandem mass spectrometry (UPLC-MS/MS). RESULTS: No significant linear associations were observed between the PFASs and intima-media thickness (IMT), or the echogenicity in the intima-media complex (IM-GSM, a marker of lipid infiltration in the artery) when men and women were analyzed together. Neither was occurrence of carotid plaques related to PFASs levels. However, highly significant interactions were observed between some PFASs and sex regarding both IM-GSM and plaque prevalence. Perfluorononanoic acid (PFNA), perfluorodecanoic acid (PFDA), and perfluoroundecanoic acid (PFUnDA), were all related to IM-GSM in a positive fashion in women (p=0.002-0.003), while these relationships were negative in men. The levels of PFUnDA were significantly related to carotid plaque in women (OR 1.59, 95%CI 1.03-2.43, p=0.03), but not in men (OR 0.93, 95%CI 0.62-1.42, p=0.75). CONCLUSIONS: In this cross-sectional study, a pronounced gender difference was observed regarding associations between some PFASs, especially the long-chain PFUnDA, and markers of atherosclerosis, with more pronounced relationships found in women. These findings suggest a sex-specific role for PFASs in atherosclerosis. Copyright Â
Authors: Philip J Landrigan; John J Stegeman; Lora E Fleming; Denis Allemand; Donald M Anderson; Lorraine C Backer; Françoise Brucker-Davis; Nicolas Chevalier; Lilian Corra; Dorota Czerucka; Marie-Yasmine Dechraoui Bottein; Barbara Demeneix; Michael Depledge; Dimitri D Deheyn; Charles J Dorman; Patrick Fénichel; Samantha Fisher; Françoise Gaill; François Galgani; William H Gaze; Laura Giuliano; Philippe Grandjean; Mark E Hahn; Amro Hamdoun; Philipp Hess; Bret Judson; Amalia Laborde; Jacqueline McGlade; Jenna Mu; Adetoun Mustapha; Maria Neira; Rachel T Noble; Maria Luiza Pedrotti; Christopher Reddy; Joacim Rocklöv; Ursula M Scharler; Hariharan Shanmugam; Gabriella Taghian; Jeroen A J M van de Water; Luigi Vezzulli; Pál Weihe; Ariana Zeka; Hervé Raps; Patrick Rampal Journal: Ann Glob Health Date: 2020-12-03 Impact factor: 2.462
Authors: Yang Hu; Ming Ding; Laura Sampson; Walter C Willett; JoAnn E Manson; Molin Wang; Bernard Rosner; Frank B Hu; Qi Sun Journal: BMJ Date: 2020-07-08
Authors: Anne P Starling; Cuining Liu; Guannan Shen; Ivana V Yang; Katerina Kechris; Sarah J Borengasser; Kristen E Boyle; Weiming Zhang; Harry A Smith; Antonia M Calafat; Richard F Hamman; John L Adgate; Dana Dabelea Journal: Environ Health Perspect Date: 2020-12-24 Impact factor: 9.031
Authors: Lars Lind; Jesus A Araujo; Aaron Barchowsky; Scott Belcher; Brian R Berridge; Nipavan Chiamvimonvat; Weihsueh A Chiu; Vincent J Cogliano; Sarah Elmore; Aimen K Farraj; Aldrin V Gomes; Cliona M McHale; Kathleen B Meyer-Tamaki; Nikki Gillum Posnack; Hugo M Vargas; Xi Yang; Lauren Zeise; Changcheng Zhou; Martyn T Smith Journal: Environ Health Perspect Date: 2021-09-24 Impact factor: 9.031
Authors: Tessa Schillemans; Carolina Donat-Vargas; Christian H Lindh; Ulf de Faire; Alicja Wolk; Karin Leander; Agneta Åkesson Journal: Environ Health Perspect Date: 2022-03-14 Impact factor: 9.031
Authors: Judith M Graber; Cora Alexander; Robert J Laumbach; Kathleen Black; Pamela Ohman Strickland; Panos G Georgopoulos; Elizabeth G Marshall; Derek G Shendell; Donald Alderson; Zhongyuan Mi; Michael Mascari; Clifford P Weisel Journal: J Expo Sci Environ Epidemiol Date: 2018-11-27 Impact factor: 5.563
Authors: Citlalli Osorio-Yáñez; Marco Sanchez-Guerra; Andres Cardenas; Pi-I D Lin; Russ Hauser; Diane R Gold; Ken P Kleinman; Marie-France Hivert; Abby F Fleisch; Antonia M Calafat; Thomas F Webster; Edward S Horton; Emily Oken Journal: Environ Int Date: 2021-02-22 Impact factor: 9.621