Yasutaka Mizuno1, Yuri Miura2, Tetsuo Yamaguchi3, Tetsuya Matsumoto4. 1. Department of Infectious Diseases, Tokyo Medical University Hospital, Tokyo, Japan. Electronic address: mizuno@tokyo-med.ac.jp. 2. Department of Microbiology Laboratory, Tokyo Medical University Hospital, Tokyo, Japan. 3. Department of Microbiology and Infectious Diseases, Toho University School of Medicine, Tokyo, Japan. 4. Department of Microbiology, Tokyo Medical University, Tokyo, Japan.
Abstract
BACKGROUND: International travel is considered a risk for colonisation with extended-spectrum β-lactamase-producing Enterobacteriaceae (ESBL-PE). To our knowledge, no studies to date have focused on ESBL-PE colonisation among long-term business travellers. Therefore this study aimed to clarify the characteristics associated with ESBL-PE colonisation in Japanese long-term business travellers. METHODS: Japanese business travellers planning to stay abroad for ≥6 months were enrolled. Of the 192 travellers, 135 provided only post-travel stool samples and 57 provided both pre- and post-travel stool samples. Additionally, microbiological analyses of ESBL-PE strains, including susceptibility tests and polymerase chain reaction amplification of CTX-M genes and their sequencing were performed. RESULTS: A post-travel survey showed that of the 55 travellers (40.7%) who tested positive for ESBL-PE after travel, the highest proportion was travellers returning from East and Central Asia. CTX-M gene analyses showed that CTX-M-15 was the most frequently observed (55.0%). A pre- and post-travel survey showed that of the 22 travellers (44.9%) acquired ESBL-PE during their travel, with acquisition most frequently observed in travellers returning from South Asia. CONCLUSION: Risk-based evaluations of ESBL-PE colonisation should be performed not only for regular tourists but also for long-term business travellers.
BACKGROUND: International travel is considered a risk for colonisation with extended-spectrum β-lactamase-producing Enterobacteriaceae (ESBL-PE). To our knowledge, no studies to date have focused on ESBL-PE colonisation among long-term business travellers. Therefore this study aimed to clarify the characteristics associated with ESBL-PE colonisation in Japanese long-term business travellers. METHODS: Japanese business travellers planning to stay abroad for ≥6 months were enrolled. Of the 192 travellers, 135 provided only post-travel stool samples and 57 provided both pre- and post-travel stool samples. Additionally, microbiological analyses of ESBL-PE strains, including susceptibility tests and polymerase chain reaction amplification of CTX-M genes and their sequencing were performed. RESULTS: A post-travel survey showed that of the 55 travellers (40.7%) who tested positive for ESBL-PE after travel, the highest proportion was travellers returning from East and Central Asia. CTX-M gene analyses showed that CTX-M-15 was the most frequently observed (55.0%). A pre- and post-travel survey showed that of the 22 travellers (44.9%) acquired ESBL-PE during their travel, with acquisition most frequently observed in travellers returning from South Asia. CONCLUSION: Risk-based evaluations of ESBL-PE colonisation should be performed not only for regular tourists but also for long-term business travellers.
Authors: Anne F Voor In 't Holt; Kees Mourik; Berend Beishuizen; Adriënne S van der Schoor; Annelies Verbon; Margreet C Vos; Juliëtte A Severin Journal: Antimicrob Resist Infect Control Date: 2020-05-20 Impact factor: 4.887
Authors: Tinja Lääveri; Jessica A Vlot; Alje P van Dam; Hanni K Häkkinen; Gerard J B Sonder; Leo G Visser; Anu Kantele Journal: BMC Infect Dis Date: 2018-07-23 Impact factor: 3.090