| Literature DB >> 27769353 |
Aaron J Stonestrom1, Sarah C Hsu1, Michael T Werner1, Gerd A Blobel2.
Abstract
Pharmacologic inhibitors of the bromodomain and extra-terminal motif (BET) protein family are in clinical trials for the treatment of hematologic malignancies, yet the functions of individual BET proteins remain largely uncharacterized. We review the molecular roles of BETs in the context of erythropoiesis. Studies in this lineage have provided valuable insights into their mechanisms of action, and helped define the individual and overlapping functions of BET protein family members BRD2, BRD3, and BRD4. These studies have important ramifications for our understanding of the molecular and physiologic roles of BET proteins, and provide a framework for elucidating some of the beneficial and adverse effects of pharmacologic inhibitors.Entities:
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Year: 2016 PMID： 27769353 PMCID： PMC5116323 DOI： 10.1016/j.ddtec.2016.05.004
Source DB: PubMed Journal: Drug Discov Today Technol ISSN： 1740-6749