| Literature DB >> 27768302 |
Sadagopan Raghavan1,2, Mahesh Kumar Rao Yelleni1,2.
Abstract
The approach to brefeldin A described herein hinges on Ru(II)-catalyzed cycloisomerization of an enyne obtained by the reaction of an alkynylzinc reagent with an α-chloro sulfide. Other key steps include Mislow-Evans rearrangement, cross-metathesis, and macrocyclization using a Roush-Masamune protocol.Entities:
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Year: 2016 PMID： 27768302 DOI： 10.1021/acs.joc.6b01964
Source DB: PubMed Journal: J Org Chem ISSN： 0022-3263 Impact factor: 4.354