Literature DB >> 2776709

Development of new pharmacological agents for epilepsy: lessons from the kindling model.

J O McNamara1.   

Abstract

The greatest value of the kindling model for new therapy of epilepsy almost certainly lies in elucidating the molecular basis of its development and persistence. Such an understanding may provide a foundation for therapies aimed at prevention or perhaps even cure of some forms of human epilepsy.

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Year:  1989        PMID： 2776709     DOI： 10.1111/j.1528-1157.1989.tb05809.x

Source DB:  PubMed          Journal:  Epilepsia        ISSN： 0013-9580            Impact factor:   5.864


  7 in total

Review 1.  Pictorial review of glutamate excitotoxicity: fundamental concepts for neuroimaging.

Authors:  L P Mark; R W Prost; J L Ulmer; M M Smith; D L Daniels; J M Strottmann; W D Brown; L Hacein-Bey
Journal:  AJNR Am J Neuroradiol       Date:  2001 Nov-Dec       Impact factor: 3.825

2.  Conventional anticonvulsant drugs in the guinea-pig kindling model of partial seizures: effects of repeated administration.

Authors:  Trevor H Gilbert; G Campbell Teskey
Journal:  Exp Brain Res       Date:  2007-01-26       Impact factor: 1.972

3.  A neural network model for kindling of focal epilepsy: basic mechanism.

Authors:  M R Mehta; C Dasgupta; G R Ullal
Journal:  Biol Cybern       Date:  1993       Impact factor: 2.086

Review 4.  Choosing the correct antiepileptic drugs: from animal studies to the clinic.

Authors:  Gregory L Holmes; Qian Zhao
Journal:  Pediatr Neurol       Date:  2008-03       Impact factor: 3.372

5.  Synthesis and anticonvulsant activities of (R)-N-(4'-substituted)benzyl 2-acetamido-3-methoxypropionamides.

Authors:  Christophe Salomé; Elise Salomé-Grosjean; Ki Duk Park; Pierre Morieux; Robert Swendiman; Erica DeMarco; James P Stables; Harold Kohn
Journal:  J Med Chem       Date:  2010-02-11       Impact factor: 7.446

Review 6.  Difficulties in Treatment and Management of Epilepsy and Challenges in New Drug Development.

Authors:  Abdul Wahab
Journal:  Pharmaceuticals (Basel)       Date:  2010-07-05

7.  Epileptic seizures and link to memory processes.

Authors:  Ritwik Das; Artur Luczak
Journal:  AIMS Neurosci       Date:  2022-03-07
  7 in total

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