Chien-Ying Lee1,2,3, Hung-Che Shih3, Min-Chien Yu4, Ming-Yung Lee5, Ya-Lan Chang2,3, Ya-Yun Lai6, Yi-Ching Lee2,3, Yu-Hsiang Kuan2,3, Chun-Che Lin7,8,9. 1. Institute of Medicine, Chung Shan Medical University, Taichung, Taiwan, 40201, China. 2. Department of Pharmacy, Chung Shan Medical University Hospital, Taichung, Taiwan, 40201, China. 3. Department of Medicine, Chung Shan Medical University, Taichung, Taiwan, China. 4. Department of Integrated Chinese and Western Medicine, Chung Shan Medical University Hospital, Taichung, Taiwan, 40201, China. 5. Department of Statistics and Informatics Science, Providence University, China, 43301, China. 6. Department of Applied Cosmetology, National Tainan Junior College of Nursing, Taiwan, 700, China. 7. Institute of Medicine, Chung Shan Medical University, Taichung, Taiwan, 40201, China. forest65@ms8.hinet.net. 8. Department of Medicine, Chung Shan Medical University, Taichung, Taiwan, China. forest65@ms8.hinet.net. 9. Division of Hepatogastroenterology, Department of Internal Medicine, Chung Shan Medical University Hospital, Taichung, Taiwan, 40201, China. forest65@ms8.hinet.net.
Abstract
OBJECTIVES: To investigate whether three strains of probiotics, L. acidophilus, L. rhamnosus, and L. sporogenes, had signifificant inhibitive effects on Helicobacter pylori (H. pylori). METHODS: This is a 4-week, randomly assigned, parallel-group, doubled-blind, and placebo-controlled study. Fifty patients with a positive H. pylori infection urea breath test (△UBT) result > 10% and without ulcer symptoms were randomized into a treatment group and a placebo group by a computer generated allocation sheet with 1:1. These subjects took one capsule of probiotics or placebo twice daily. The primary measurement was the change in △UBT values. RESULTS: The △UBT values during the 4-week treatment period and the 2-week follow-up period were not signifificantly different between the treatment group and the placebo group, indicating that the inhibitive effects on H. pylori were comparable between both groups. The monocyte count (%) was 5.77±1.11 in the treatment group versus 5.09±1.12 in the placebo group (P=0.044), and the basophile count was 0.55±0.32 in the treatment group versus 0.36±0.23 in the placebo group (P=0.024) at week 2 of the treatment period, both of which reached statistical signifificance. The monocyte count was 5.75±1.26 in the treatment group and 4.72±0.99 in the placebo group at the end of the follow-up period (P=0.003). CONCLUSION: There was no signifificant inhibitive effects of the three probiotic strains (L. acidophilus, L. rhamnosus, and L. sporogenes) on H. pylori. Probiotics can not play the same role as antibiotics in the eradication of H. pylori, the role of probiotics is likely to be important as adjuvant to the triple or quadruple therapy for H. pylori, especially in resistance cases.
RCT Entities:
OBJECTIVES: To investigate whether three strains of probiotics, L. acidophilus, L. rhamnosus, and L. sporogenes, had signifificant inhibitive effects on Helicobacter pylori (H. pylori). METHODS: This is a 4-week, randomly assigned, parallel-group, doubled-blind, and placebo-controlled study. Fifty patients with a positive H. pyloriinfection urea breath test (△UBT) result > 10% and without ulcer symptoms were randomized into a treatment group and a placebo group by a computer generated allocation sheet with 1:1. These subjects took one capsule of probiotics or placebo twice daily. The primary measurement was the change in △UBT values. RESULTS: The △UBT values during the 4-week treatment period and the 2-week follow-up period were not signifificantly different between the treatment group and the placebo group, indicating that the inhibitive effects on H. pylori were comparable between both groups. The monocyte count (%) was 5.77±1.11 in the treatment group versus 5.09±1.12 in the placebo group (P=0.044), and the basophile count was 0.55±0.32 in the treatment group versus 0.36±0.23 in the placebo group (P=0.024) at week 2 of the treatment period, both of which reached statistical signifificance. The monocyte count was 5.75±1.26 in the treatment group and 4.72±0.99 in the placebo group at the end of the follow-up period (P=0.003). CONCLUSION: There was no signifificant inhibitive effects of the three probiotic strains (L. acidophilus, L. rhamnosus, and L. sporogenes) on H. pylori. Probiotics can not play the same role as antibiotics in the eradication of H. pylori, the role of probiotics is likely to be important as adjuvant to the triple or quadruple therapy for H. pylori, especially in resistance cases.
Authors: Luiz Gonzaga Vaz Coelho; Arilto Eleutério da Silva; Maria Clara de Freitas Coelho; Francisco Guilherme Cancela e Penna; Rafael Otto Antunes Ferreira; Elisa Viana Santa-Cecilia Journal: Arq Gastroenterol Date: 2011 Apr-Jun
Authors: J A da Silva Medeiros; T M F O Gonçalves; L Boyanova; M I de Correia Pereira; J N da Silva Paiva de Carvalho; A M de Sousa Pereira; A M Silvério Cabrita Journal: Eur J Clin Microbiol Infect Dis Date: 2011-01-05 Impact factor: 3.267
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