Literature DB >> 27761789

Skin steroidogenesis in health and disease.

Georgios Nikolakis1, Constantine A Stratakis2, Theodora Kanaki3, Andrej Slominski4, Christos C Zouboulis3.   

Abstract

The skin is an important extra-gonadal steroidogenic organ, capable of metabolizing various hormones from their precursors, as well as of synthesizing de novo a broad palette of sex steroids and glucocorticoids from cholesterol. In this manuscript, we review the major steroidogenic properties of human skin and we suggest steroidogenesis' impairment as a cardinal factor for various pathological conditions such as acne, rosacea, atopic dermatitis, and androgenic alopecia.

Entities:  

Keywords:  5a-reductase; Acne; Androgen receptor; Androgens; Aromatase; DHEA; Dermatoendocrinology; Estrogens; Glucocorticoids; Rosacea; Steroidogenesis; Steroids; Testosterone

Mesh：

Substances：

Year:  2016        PMID： 27761789     DOI： 10.1007/s11154-016-9390-z

Source DB:  PubMed          Journal:  Rev Endocr Metab Disord        ISSN： 1389-9155            Impact factor:   6.514


  157 in total

1.  Estrogens and human scalp hair growth-still more questions than answers.

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2.  Rhinophyma--unusual expression of simple-type keratins and S100A in sebocytes and abundance of VIP receptor-positive dermal cells.

Authors:  U Wollina
Journal:  Histol Histopathol       Date:  1996-01       Impact factor: 2.303

3.  Gas chromatography/mass spectrometry characterization of corticosteroid metabolism in human immortalized keratinocytes.

Authors:  Andrzej Slominski; Jacobo Wortsman; Mark F Foecking; Cedric Shackleton; Celso Gomez-Sanchez; Andre Szczesniewski
Journal:  J Invest Dermatol       Date:  2002-02       Impact factor: 8.551

4.  The role of neuropeptides in the multifactorial pathogenesis of acne vulgaris.

Authors:  Ruta Ganceviciene; Markus Böhm; Sabine Fimmel; Christos C Zouboulis
Journal:  Dermatoendocrinol       Date:  2009-05

Review 5.  Steroid hormone receptors and melanoma.

Authors:  J P Neifeld; M E Lippman
Journal:  J Invest Dermatol       Date:  1980-06       Impact factor: 8.551

6.  The aromatase excess syndrome is associated with feminization of both sexes and autosomal dominant transmission of aberrant P450 aromatase gene transcription.

Authors:  C A Stratakis; A Vottero; A Brodie; L S Kirschner; D DeAtkine; Q Lu; W Yue; C S Mitsiades; A W Flor; G P Chrousos
Journal:  J Clin Endocrinol Metab       Date:  1998-04       Impact factor: 5.958

7.  A novel pathway for sequential transformation of 7-dehydrocholesterol and expression of the P450scc system in mammalian skin.

Authors:  Andrzej Slominski; Jordan Zjawiony; Jacobo Wortsman; Igor Semak; Jeremy Stewart; Alexander Pisarchik; Trevor Sweatman; Josep Marcos; Chuck Dunbar; Robert C Tuckey
Journal:  Eur J Biochem       Date:  2004-11

8.  Comprehensive screening for a complete set of Japanese-population-specific filaggrin gene mutations.

Authors:  M Kono; T Nomura; Y Ohguchi; O Mizuno; S Suzuki; H Tsujiuchi; N Hamajima; W H I McLean; H Shimizu; M Akiyama
Journal:  Allergy       Date:  2014-01-28       Impact factor: 13.146

Review 9.  History of aromatase: saga of an important biological mediator and therapeutic target.

Authors:  R J Santen; H Brodie; E R Simpson; P K Siiteri; A Brodie
Journal:  Endocr Rev       Date:  2009-04-23       Impact factor: 19.871

10.  17alpha-estradiol induces aromatase activity in intact human anagen hair follicles ex vivo.

Authors:  R Hoffmann; S Niiyama; A Huth; S Kissling; R Happle
Journal:  Exp Dermatol       Date:  2002-08       Impact factor: 3.960
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  15 in total

1.  Metabolism and skin diseases.

Authors:  Christos C Zouboulis; Constantine A Stratakis; George P Chrousos; Christian A Koch
Journal:  Rev Endocr Metab Disord       Date:  2016-09       Impact factor: 6.514

Review 2.  How UV Light Touches the Brain and Endocrine System Through Skin, and Why.

Authors:  Andrzej T Slominski; Michal A Zmijewski; Przemyslaw M Plonka; Jerzy P Szaflarski; Ralf Paus
Journal:  Endocrinology       Date:  2018-05-01       Impact factor: 4.736

3.  Seasonal changes in steroid and thyroid hormone content in shed skins of the tegu lizard Salvator merianae.

Authors:  Lucas A Zena; Danielle Dillon; Kathleen E Hunt; Carlos A Navas; Kênia C Bícego; C Loren Buck
Journal:  J Comp Physiol B       Date:  2021-08-11       Impact factor: 2.200

4.  Effects of testosterone on skin structure and factors related to androgen conversion and binding in Hetian sheep.

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Journal:  Trop Anim Health Prod       Date:  2022-06-27       Impact factor: 1.893

Review 5.  Factors Influencing Skin Aging and the Important Role of Estrogens and Selective Estrogen Receptor Modulators (SERMs).

Authors:  Edwin D Lephart; Frederick Naftolin
Journal:  Clin Cosmet Investig Dermatol       Date:  2022-08-19

6.  Estrogen regulates the expression of retinoic acid synthesis enzymes and binding proteins in mouse skin.

Authors:  Helen B Everts; Kathleen A Silva; Adriana N Schmidt; Susan Opalenik; F Jason Duncan; Lloyd E King; John P Sundberg; David E Ong
Journal:  Nutr Res       Date:  2021-08-24       Impact factor: 3.876

7.  The significance of CYP11A1 expression in skin physiology and pathology.

Authors:  R M Slominski; C Raman; C Elmets; A M Jetten; A T Slominski; R C Tuckey
Journal:  Mol Cell Endocrinol       Date:  2021-03-12       Impact factor: 4.369

8.  The quantification of reproductive hormones in the hair of captive adult brown bears and their application as indicators of sex and reproductive state.

Authors:  Marc Cattet; Gordon B Stenhouse; David M Janz; Luciene Kapronczai; Joy Anne Erlenbach; Heiko T Jansen; O Lynne Nelson; Charles T Robbins; John Boulanger
Journal:  Conserv Physiol       Date:  2017-06-01       Impact factor: 3.079

9.  Novel insights into the pathways regulating the canine hair cycle and their deregulation in alopecia X.

Authors:  Magdalena A T Brunner; Vidhya Jagannathan; Dominik P Waluk; Petra Roosje; Monika Linek; Lucia Panakova; Tosso Leeb; Dominique J Wiener; Monika M Welle
Journal:  PLoS One       Date:  2017-10-24       Impact factor: 3.240

Review 10.  Extra-adrenal glucocorticoid biosynthesis: implications for autoimmune and inflammatory disorders.

Authors:  Radomir M Slominski; Robert C Tuckey; Pulak R Manna; Anton M Jetten; Arnold Postlethwaite; Chander Raman; Andrzej T Slominski
Journal:  Genes Immun       Date:  2020-03-23       Impact factor: 2.676
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