Rauf Shahbazov1, Gumpei Yoshimatsu2, Waqas Z Haque2, Omar S Khan2, Giovanna Saracino3, Michael C Lawrence2, Peter T Kim3, Nicholas Onaca3, Bashoo Naziruddin4, Marlon F Levy5. 1. Department of Surgery, University of Virginia, Charlottesville, VA, USA. 2. Islet Cell Laboratory, Baylor Research Institute, Dallas, TX, USA. 3. Annette C. and Harold C. Simmons Transplant Institute, Baylor University Medical Center, Dallas, TX, USA. 4. Annette C. and Harold C. Simmons Transplant Institute, Baylor University Medical Center, Dallas, TX, USA. Electronic address: Bashoo.Naziruddin@BSWHealth.org. 5. Transplant Division, Department of Surgery, Virginia Commonwealth University Medical Center, Richmond, VA, USA.
Abstract
BACKGROUND: The impact of pylorus preserving procedures (PP) on total pancreatectomy with islet autotransplantation (TPIAT) has not been examined. This study aimed to investigate the clinical impact of the PP on TPIAT. METHODS: The Baylor Simmons Transplant Institute database was queried to identify seventy-three patients who underwent TPIAT from 2006 to 2014. All patients were investigated in postoperative complications, long-term nutritional status, and graft function. RESULTS: Patients with PP did not face worse outcomes in terms of delayed gastric emptying and length of hospital stay. Also, nutritional status and metabolic outcome, such as body weight, serum albumin level, serum vitamin level, HbA1c level, graft survival rate and insulin independent rate, were similar between both groups. CONCLUSIONS: Clinical results including the graft function indicated that patients undergoing TPIAT with PP did not amplify surgical complications such as delayed gastric emptying and showed no significant advantage of nutrition and metabolic outcome.
BACKGROUND: The impact of pylorus preserving procedures (PP) on total pancreatectomy with islet autotransplantation (TPIAT) has not been examined. This study aimed to investigate the clinical impact of the PP on TPIAT. METHODS: The Baylor Simmons Transplant Institute database was queried to identify seventy-three patients who underwent TPIAT from 2006 to 2014. All patients were investigated in postoperative complications, long-term nutritional status, and graft function. RESULTS:Patients with PP did not face worse outcomes in terms of delayed gastric emptying and length of hospital stay. Also, nutritional status and metabolic outcome, such as body weight, serum albumin level, serum vitamin level, HbA1c level, graft survival rate and insulin independent rate, were similar between both groups. CONCLUSIONS: Clinical results including the graft function indicated that patients undergoing TPIAT with PP did not amplify surgical complications such as delayed gastric emptying and showed no significant advantage of nutrition and metabolic outcome.
Authors: Malini Ahuja; Daniella M Schwartz; Mayank Tandon; Aran Son; Mei Zeng; William Swaim; Michael Eckhaus; Victoria Hoffman; Yiyuan Cui; Bo Xiao; Paul F Worley; Shmuel Muallem Journal: Cell Metab Date: 2017-03-07 Impact factor: 27.287
Authors: Jaimie D Nathan; Yi Yang; Anne Eaton; Piotr Witkowski; Martin Wijkstrom; Matthew Walsh; Guru Trikudanathan; Vikesh K Singh; Sarah J Schwarzenberg; Timothy L Pruett; Andrew Posselt; Bashoo Naziruddin; Sri Prakash Mokshagundam; Katherine Morgan; Luis F Lara; Varvara Kirchner; Jin He; Timothy B Gardner; Martin L Freeman; Kate Ellery; Darwin L Conwell; Srinath Chinnakotla; Gregory J Beilman; Syed Ahmad; Maisam Abu-El-Haija; James S Hodges; Melena D Bellin Journal: Pancreatology Date: 2021-09-29 Impact factor: 3.996
Authors: Varvara A Kirchner; Ty B Dunn; Gregory J Beilman; Srinath Chinnakotla; Timothy L Pruett; Joshua J Wilhelm; Sarah J Schwarzenberg; Martin L Freeman; Melena D Bellin Journal: Curr Treat Options Gastroenterol Date: 2017-12