Rafael Mesquita1, Frits M E Franssen2, Sarah Houben-Wilke2, Nicole H M K Uszko-Lencer3, Lowie E G W Vanfleteren4, Yvonne M J Goërtz2, Fabio Pitta5, Emiel F M Wouters4, Martijn A Spruit2. 1. Department of Research & Education, CIRO, Horn, The Netherlands; Department of Respiratory Medicine, Maastricht University Medical Center+ (MUMC+), Maastricht, The Netherlands. Electronic address: rafaelmesquita14@ymail.com. 2. Department of Research & Education, CIRO, Horn, The Netherlands. 3. Department of Research & Education, CIRO, Horn, The Netherlands; Department of Cardiology, Maastricht University Medical Center + (MUMC+), Maastricht, The Netherlands. 4. Department of Research & Education, CIRO, Horn, The Netherlands; Department of Respiratory Medicine, Maastricht University Medical Center+ (MUMC+), Maastricht, The Netherlands. 5. Laboratory of Research in Respiratory Physiotherapy, Department of Physiotherapy, State University of Londrina (UEL), Londrina, Brazil.
Abstract
BACKGROUND: It remains unknown whether and to what extent impaired left ventricular ejection fraction (LVEF) affects physical and psychological status in COPD. We aimed to compare health outcome measures between COPD patients with and without impaired LVEF after adjusting for age, sex, BMI and FEV1. METHODS: Impaired LVEF was defined as values <50%. 85 COPD patients with impaired LVEF and 85 COPD patients with normal LVEF were matched for sex, age, BMI and FEV1. Exercise capacity, quadriceps muscle function, functional mobility, inflammatory status, health status, care dependency, and mood disorders were cross-sectionally assessed. RESULTS: Patients with impaired LVEF had shorter 6-minute walk distance (mean -59 (95% confidence interval: -94, -25)m), lower symptom-limited peak oxygen uptake (-131 (-268, 7)ml/min), weaker quadriceps muscles (-12 (-20, -3)Nm) and had more symptoms of anxiety (+2 (1, 3) points) and depression (+1 (0, 2) points) than those with normal LVEF (all P<0.05). Health status was not statistically different between groups (P>0.05). CONCLUSIONS: Impaired LVEF has a clear impact on physical and psychological status in patients with COPD, even after adjusting for confounders. This reinforces the importance of assessing and treating cardiac problems in COPD.
BACKGROUND: It remains unknown whether and to what extent impaired left ventricular ejection fraction (LVEF) affects physical and psychological status in COPD. We aimed to compare health outcome measures between COPDpatients with and without impaired LVEF after adjusting for age, sex, BMI and FEV1. METHODS:Impaired LVEF was defined as values <50%. 85 COPDpatients with impaired LVEF and 85 COPDpatients with normal LVEF were matched for sex, age, BMI and FEV1. Exercise capacity, quadriceps muscle function, functional mobility, inflammatory status, health status, care dependency, and mood disorders were cross-sectionally assessed. RESULTS:Patients with impaired LVEF had shorter 6-minute walk distance (mean -59 (95% confidence interval: -94, -25)m), lower symptom-limited peak oxygen uptake (-131 (-268, 7)ml/min), weaker quadriceps muscles (-12 (-20, -3)Nm) and had more symptoms of anxiety (+2 (1, 3) points) and depression (+1 (0, 2) points) than those with normal LVEF (all P<0.05). Health status was not statistically different between groups (P>0.05). CONCLUSIONS:Impaired LVEF has a clear impact on physical and psychological status in patients with COPD, even after adjusting for confounders. This reinforces the importance of assessing and treating cardiac problems in COPD.
Authors: Nicole L Spartano; Kendra L Davis-Plourde; Jayandra J Himali; Charlotte Andersson; Matthew P Pase; Pauline Maillard; Charles DeCarli; Joanne M Murabito; Alexa S Beiser; Ramachandran S Vasan; Sudha Seshadri Journal: JAMA Netw Open Date: 2019-04-05
Authors: Peter Alter; Barbara A Mayerhofer; Kathrin Kahnert; Henrik Watz; Benjamin Waschki; Stefan Andreas; Frank Biertz; Robert Bals; Claus F Vogelmeier; Rudolf A Jörres Journal: Int J Chron Obstruct Pulmon Dis Date: 2019-09-20
Authors: Sarah Houben-Wilke; Daisy J A Janssen; Frits M E Franssen; Lowie E G W Vanfleteren; Emiel F M Wouters; Martijn A Spruit Journal: Health Qual Life Outcomes Date: 2018-10-30 Impact factor: 3.186