| Literature DB >> 27760333 |
Abstract
In tuberculosis, some macrophages in granulomas assume an epitheloid appearance. Using the Mycobacterium marinum-zebrafish model, Cronan et al. (2016) now show that granuloma macrophages undergo reprograming events involving E-cadherin-dependent formation of epithelial-like cell-cell junctions. Interference with the function of E-cadherin in macrophages disorganized the granulomas and protected the fish, introducing new ideas and questions about macrophage function and granulomatous diseases.Entities:
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Year: 2016 PMID： 27760333 DOI： 10.1016/j.immuni.2016.10.002
Source DB: PubMed Journal: Immunity ISSN： 1074-7613 Impact factor: 31.745