| Literature DB >> 27760326 |
Frederick J Kohlhapp1, Erica J Huelsmann2, Andrew T Lacek2, Jason M Schenkel3, Jevgenijs Lusciks4, Joseph R Broucek5, Josef W Goldufsky2, Tasha Hughes5, Janet P Zayas2, Hubert Dolubizno2, Ryan T Sowell2, Regina Kühner2, Sarah Burd6, John C Kubasiak5, Arman Nabatiyan4, Sh'Rae Marshall7, Praveen K Bommareddy7, Shengguo Li7, Jenna H Newman7, Claude E Monken1, Sasha H Shafikhani2, Amanda L Marzo4, Jose A Guevara-Patino8, Ahmed Lasfar9, Paul G Thomas10, Edmund C Lattime1, Howard L Kaufman1, Andrew Zloza11.
Abstract
In light of increased cancer prevalence and cancer-specific deaths in patients with infections, we investigated whether infections alter anti-tumor immune responses. We report that acute influenza infection of the lung promotes distal melanoma growth in the dermis and leads to accelerated cancer-specific host death. Furthermore, we show that during influenza infection, anti-melanoma CD8+ T cells are shunted from the tumor to the infection site, where they express high levels of the inhibitory receptor programmed cell death protein 1 (PD-1). Immunotherapy to block PD-1 reverses this loss of anti-tumor CD8+ T cells from the tumor and decreases infection-induced tumor growth. Our findings show that acute non-oncogenic infection can promote cancer growth, raising concerns regarding acute viral illness sequelae. They also suggest an unexpected role for PD-1 blockade in cancer immunotherapy and provide insight into the immune response when faced with concomitant challenges.Entities:
Keywords: CD8(+) T cells; PD-1; breast cancer; cancer; concomitant; infection; influenza; melanoma; mouse; viral
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Year: 2016 PMID： 27760326 PMCID： PMC5589518 DOI： 10.1016/j.celrep.2016.09.068
Source DB: PubMed Journal: Cell Rep Impact factor: 9.423