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Correction: Literature-Informed Analysis of a Genome-Wide Association Study of Gestational Age in Norwegian Women and Children Suggests Involvement of Inflammatory Pathways.

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Abstract

[This corrects the article DOI: 10.1371/journal.pone.0160335.].

Entities:  

Year:  2016        PMID: 27760235      PMCID: PMC5070847          DOI: 10.1371/journal.pone.0165328

Source DB:  PubMed          Journal:  PLoS One        ISSN: 1932-6203            Impact factor:   3.240


The captions for Tables 1 and 4 were incorrectly incorporated in the manuscript text. The authors have provided the correct tables and captions here. The publisher apologizes for this error.
Table 1

Top 20 independent loci from maternal GWAS of gestational age in labor-initiated deliveries.

ChrBPSNPPE/RModnEEnERnRRmEEmERmRRGenes
6164389165rs5932543.32e-6A/GADD76480851260264268
2134837980rs134105045.64e-6G/AREC72371163221265267
1226209989rs175150101.00e-5G/AREC41411261205264266SDE2, PYCR2, LEFTY2, H3F3A, H3F3AP4
181391541rs171056991.03e-5G/ADOM61651232273259267
207618077rs60861321.06e-5A/GDOM162649596269268263
510501076rs25896581.15e-5C/AREC330684393262267267ROPN1L, ROPN1L-AS1, MARCH6, ANKRD33B
4103537442rs16097981.48e-5A/GREC128601677259266268NFKB1, MANBA
9130417033rs101170751.55e-5A/GREC121901205237268266TTC16, TOR2A, STXBP1, SH2D3C, PTRH1, FAM129B
1491352234rs65751651.56e-5A/GADD87478842260264268TTC7B, RPS6KA5
1088336279rs25882781.58e-5A/GADD260680467270266264WAPAL, OPN4, LDB3
136879232rs30072171.81e-5G/AADD150593664270268264STK40, SH3D21, OSCP1, MRPS15, LSM10, EVA1B, CSF3R
1618067234rs1516991.86e-5C/AREC11331272161266266
163344618rs2203812.12e-5G/ADOM159559689270268264ZSCAN32, TIGD7, OR2C1, OR1F2P, OR1F1, MTRNR2L4, MEFV
1087762136rs112018672.33e-5A/GADD223041081275270265GRID1
122345093rs31170482.49e-5A/GREC146633628273266265WNT4, HSPG2, CELA3B, CELA3A, CDC42
4112524778rs100152142.60e-5A/GDOM312675420266268263
641164005rs69150832.64e-5G/AREC197648561261268266TREM*, TREML*, NFYA, ADCY10P1
1685941774rs3050802.67e-5A/GREC143586678273266265IRF8
188453303rs30084652.67e-5C/AADD71532802272268264
6123749752rs13439622.80e-5A/GADD303713390263266269TRDN

Table 1 was pruned to show only independent loci. BP—physical position on the chromosome in hg19 coordinates, P—the most extreme empirical p-value from three genetic models, E/R—the effect allele and the reference allele, Mod—the most significant genetic model for that SNP, nXX—number of individuals in each genotypic group, mXX—mean gestational age in each genotypic group. Interpretation of mean gestational age values should take into account the bimodal phenotype distribution of genotyped individuals (S1 Fig). Genes were assigned to SNPs based on a 100 kb offset rule. Asterisk (*) indicates a gene family with multiple genes in that locus. No multiple-test correction is applied. Bolded genes are described in the literature-informed analyses. Genes with unknown function (LINC, LOC etc.) are not listed.

Table 4

Loci of biological relevance from maternal GWAS of gestational age in labor-initiated deliveries.

RankSNPChrBPPE/RModnEEnERnRRmEEmERmRRGenes
5rs1751501012262099891.00e-5G/AREC41411261205264266LEFTY2
10rs160979841035374421.48e-5A/GREC128601677259266268NFKB1
11rs1011707591304170331.55e-5A/GREC121901205237268266ENG
13rs228711691304208131.55e-5A/CREC122101185237267266TOR2A
19rs2203811633446182.12e-5G/ADOM159559689270268264MEFV
22rs31170481223450932.49e-5A/GREC146633628273266265WNT4
24rs69150836411640052.64e-5G/AREC197648561261268266TREM1, TREML2, TREML4
25rs30508016859417742.67e-5A/GREC143586678273266265IRF8
41rs43126733484013073.67e-5A/GDOM1721332282256267CAMP
65rs6343351363358625.63e-5C/ADOM233101074266262267AGO3
66rs671818821747616115.73e-5A/CADD157611638269268264SP3
75rs1233696991076795006.10e-5A/CREC72011199229267266ABCA1
88rs21775397166525237.24e-5G/AREC109566728259267267ANKMY2
98rs39133693554810758.22e-5A/CADD69498840262264268WNT5A
100rs1213803911569181378.29e-5A/GDOM61851214259261267ARHGEF11
101rs407568831958482648.30e-5G/AREC177668559261266268TFRC
106rs478986317768973478.52e-5A/GDOM11221281251259267TIMP2
109rs1186627116248811528.74e-5C/ADOM107582713266264268TNRC6A
117rs302127422403950849.22e-5A/GDOM230653524269267264TNRC6B
138rs1220261161542374431.08e-4G/AREC72951105230266266OPRM1
146rs39564314565416381.12e-4G/AREC143101083242266266PELI2
157rs23011371270189491.22e-4A/GDOM86536784267263268GNB3, SPSB2
173rs1243536614358383891.41e-4A/GREC97550745259267266NFKBIA
197rs704595391204857951.56e-4G/AADD37379991272269265TLR4
266rs374651220445926362.18e-4A/GREC34394979253266267MMP9
284rs484912221135609212.34e-4G/AREC71581242233266266IL1A, IL1B
293rs145777681333606602.39e-4A/GREC52433922256266267KCNQ3
299rs94236413288960972.44e-4A/GDOM203071080270262267PAN3

The SNPs were selected from the top 300 GWAS results, based on their proximity and/or functional relationship with genes biologically relevant to gestational age. Rank—the rank of that SNP among all GWAS results, based on the most significant empirical p-value (P) from three genetic models, BP—physical position on the chromosome (Chr) in hg19 coordinates, E/R—the effect allele and the reference allele, Mod—the most significant genetic model for that SNP, nXX—number of individuals in each genotypic group, mXX—mean of gestational age in each genotypic group. Interpretation of mean gestational age values should take into account the bimodal phenotype distribution of genotyped individuals (S1 Fig). No multiple-test correction is applied.

Table 1 was pruned to show only independent loci. BP—physical position on the chromosome in hg19 coordinates, P—the most extreme empirical p-value from three genetic models, E/R—the effect allele and the reference allele, Mod—the most significant genetic model for that SNP, nXX—number of individuals in each genotypic group, mXX—mean gestational age in each genotypic group. Interpretation of mean gestational age values should take into account the bimodal phenotype distribution of genotyped individuals (S1 Fig). Genes were assigned to SNPs based on a 100 kb offset rule. Asterisk (*) indicates a gene family with multiple genes in that locus. No multiple-test correction is applied. Bolded genes are described in the literature-informed analyses. Genes with unknown function (LINC, LOC etc.) are not listed. The SNPs were selected from the top 300 GWAS results, based on their proximity and/or functional relationship with genes biologically relevant to gestational age. Rank—the rank of that SNP among all GWAS results, based on the most significant empirical p-value (P) from three genetic models, BP—physical position on the chromosome (Chr) in hg19 coordinates, E/R—the effect allele and the reference allele, Mod—the most significant genetic model for that SNP, nXX—number of individuals in each genotypic group, mXX—mean of gestational age in each genotypic group. Interpretation of mean gestational age values should take into account the bimodal phenotype distribution of genotyped individuals (S1 Fig). No multiple-test correction is applied.
  1 in total

1.  Literature-Informed Analysis of a Genome-Wide Association Study of Gestational Age in Norwegian Women and Children Suggests Involvement of Inflammatory Pathways.

Authors:  Jonas Bacelis; Julius Juodakis; Verena Sengpiel; Ge Zhang; Ronny Myhre; Louis J Muglia; Staffan Nilsson; Bo Jacobsson
Journal:  PLoS One       Date:  2016-08-04       Impact factor: 3.240

  1 in total

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