Literature DB >> 27758121

Kidney injury molecule-1 in kidney disease.

Caixia Yin1, Ningning Wang1.   

Abstract

Kidney injury molecule-1(KIM-1) is a type I membrane protein, comprising an extracellular portion and a cytoplasmic portion, which is expressed at very low levels in the normal kidney. The extracellular portion can cleave and rapidly enter tubule lumens after kidney injury, and can then be detected in the urine. It has been confirmed that the urine KIM-1 level is closely related to tissue KIM-1 level and correlated with kidney tissue damage. Not only is KIM-1 proven to be an early biomarker of acute kidney injury but it also has a potential role in predicting long-term renal outcome. This review summarizes the relationships between KIM-1 and kidney injury, especially in chronic kidney disease.

Entities:  

Keywords:  Acute kidney injury; biomarker; chronic kidney disease; kidney injury molecule-1

Mesh：

Substances：

Year:  2016        PMID： 27758121     DOI： 10.1080/0886022X.2016.1193816

Source DB:  PubMed          Journal:  Ren Fail        ISSN： 0886-022X            Impact factor:   2.606


  23 in total

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