Fen Li1,2, Xiaohua Pei1, Xiaoshuang Ye1,3, Xun Liu4, Dan Song5, Xiaoxuan Zhang6, Bei Zhu1, Lu Wei1, Jin Zhu7, Weihong Zhao8. 1. Division of Nephrology, Department of Geriatrics, The First Affiliated Hospital of Nanjing Medical University, 300 Guangzhou Road, Nanjing, 210029, Jiangsu, People's Republic of China. 2. Department of Nephrology, Qingdao No.8 People's Hospital, Qingdao, Shandong, People's Republic of China. 3. Department of Nephrology, Jiangsu Geriatric Hospital, Nanjing, Jiangsu, People's Republic of China. 4. Departmentof Nephrology, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong, People's Republic of China. 5. Department of Nephrology, The Affiliated Wuxi No.2 Hospital of Nanjing Medical University, Wuxi, Jiangsu, People's Republic of China. 6. Department of Nephrology, The Fourth Hospital of Jilin University, Changchun, Jilin, People's Republic of China. 7. Institute of Pattern Recognition and Machine Intelligence, School of Computer Science, Nanjing University of Science and Technology, Nanjing, Jiangsu, People's Republic of China. 8. Division of Nephrology, Department of Geriatrics, The First Affiliated Hospital of Nanjing Medical University, 300 Guangzhou Road, Nanjing, 210029, Jiangsu, People's Republic of China. zhaoweihongny@njmu.edu.cn.
Abstract
BACKGROUND: Our previous studies demonstrated that 2012 Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) equations were inaccurate enough for estimating glomerular filtration rate in elderly Chinese. Thus, this study was constructed to modify these equations. METHODS: A total of 839 subjects (aged ≥60 years) from four hospitals in China between October 2009 and December 2014 were included. A random sample of 674 (80.3 %) subjects was used as a training sample set, and the remaining 165 (19.7 %) subjects as the verification set. The equations were modified using the hill-climbing algorithm. RESULTS: Compared with the original CKD-EPI equations, the accuracy assessment indexes (bias, precision, accuracy and misclassification) were obviously improved after modification. Bland-Altman analysis also demonstrated that this modification attempt gained success to some extent. CONCLUSIONS: The modified 2012 CKD-EPI equations could be more accurate than the original equations for elderly Chinese individuals.
BACKGROUND: Our previous studies demonstrated that 2012 Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) equations were inaccurate enough for estimating glomerular filtration rate in elderly Chinese. Thus, this study was constructed to modify these equations. METHODS: A total of 839 subjects (aged ≥60 years) from four hospitals in China between October 2009 and December 2014 were included. A random sample of 674 (80.3 %) subjects was used as a training sample set, and the remaining 165 (19.7 %) subjects as the verification set. The equations were modified using the hill-climbing algorithm. RESULTS: Compared with the original CKD-EPI equations, the accuracy assessment indexes (bias, precision, accuracy and misclassification) were obviously improved after modification. Bland-Altman analysis also demonstrated that this modification attempt gained success to some extent. CONCLUSIONS: The modified 2012 CKD-EPI equations could be more accurate than the original equations for elderly Chinese individuals.
Authors: Lesley A Inker; Christopher H Schmid; Hocine Tighiouart; John H Eckfeldt; Harold I Feldman; Tom Greene; John W Kusek; Jane Manzi; Frederick Van Lente; Yaping Lucy Zhang; Josef Coresh; Andrew S Levey Journal: N Engl J Med Date: 2012-07-05 Impact factor: 91.245
Authors: Lesley A Inker; Brad C Astor; Chester H Fox; Tamara Isakova; James P Lash; Carmen A Peralta; Manjula Kurella Tamura; Harold I Feldman Journal: Am J Kidney Dis Date: 2014-03-16 Impact factor: 8.860