| Literature DB >> 27756179 |
Shuai Jiang1,2, Yang Yang3,4, Tian Li3, Zhiqiang Ma5, Wei Hu3, Chao Deng1, Chongxi Fan5, Jianjun Lv3, Yang Sun6, Wei Yi1.
Abstract
INTRODUCTION: Nuclear factor erythroid 2-related factor 2 (Nrf2) is a basic leucine zipper (bZIP) transcription factor of the cap'n'collar (CNC) family that is present in various organs. The cardiovascular system (CVS) is susceptible to a spectrum of diseases that are strongly associated with increased risks of mortality and morbidity, and studies have demonstrated that Nrf2 has a pivotal role in protection against cardiovascular diseases (CVDs). Areas covered: Nrf2 is a basic protective molecule that guards against CVD by attenuating oxidative stress, mitochondrial dysfunction, and inflammation. Initially, we briefly introduce the biological characteristics of Nrf2 and the newly discovered Neh7 domain. Next, we discuss the concrete roles of Nrf2 in the CVS and enumerate some related upstream molecules and downstream targets. Lastly, we expand our focus to the behaviors of Nrf2 in CVDs and discuss potential research directions. Expert opinion: Although certain studies have cast doubt on the positive actions of Nrf2 in the CVS, Nrf2 is a pivotal endogenous molecule for defense against CVD. The review compiled here may serve as a broad and comprehensive reference for the roles of Nrf2 in the CVS, with the aim of facilitating the design of new drugs and clinical therapies for CVDs.Entities:
Keywords: Nuclear factor erythroid 2-related factor 2; cardiovascular system; oxidative stress; potential research directions
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Year: 2016 PMID： 27756179 DOI： 10.1080/14728222.2016.1250887
Source DB: PubMed Journal: Expert Opin Ther Targets ISSN： 1472-8222 Impact factor: 6.902