Rogan G Fraser1, Rose Tan1, Lauren N Ayton1, Emily Caruso1, Robyn H Guymer1, Chi D Luu1. 1. Centre for Eye Research Australia, Royal Victorian Eye and Ear Hospital, East Melbourne, Victoria, Australia; Department of Surgery (Ophthalmology), The University of Melbourne, Parkville, Victoria, Australia.
Abstract
PURPOSE: We determine the feasibility of using a dark-adapted chromatic (DAC) perimeter to obtain dark-adapted static and dynamic rod function at multiple retinal locations, and compare these functional parameters between subjects with intermediate age-related macular degeneration (AMD) and normal controls. METHODS: Perimetric dark-adapted retinal sensitivities for the 505 and 620 nm stimuli across 7 retinal locations within the central 12° were repeatedly measured after exposing to a single photobleach in 22 intermediate AMD subjects and 8 controls. The sensitivities for each stimulus at 20 minutes after bleach and the sensitivity difference between the stimuli were used to determine static rod function. Sensitivities for the 505 nm stimulus at various times within the initial 20 minutes after bleach were used to estimate the rod criterion time to determine rod function dynamics. The static and dynamic rod functional parameters were compared between AMD and control eyes. RESULTS: Compared to the control eyes, AMD eyes had a reduction in retinal sensitivities for the 505 nm (P < 0.001) and 620 nm (P < 0.001) stimuli, a reduction in sensitivity difference (P < 0.001), and an increased in rod criterion time (P < 0.001). Region within the central 6° appeared to be the most defective and AMD eyes with reticular pseudodrusen (RPD) seemed to have worse function than eyes without RPD. CONCLUSIONS: It is feasible to use a DAC perimeter to study dark-adapted static and dynamic rod-mediated function at multiple retinal loci. Static and dynamic rod function were abnormal in intermediate AMD and more so in eyes with RPD, particularly within the central 6° retina.
PURPOSE: We determine the feasibility of using a dark-adapted chromatic (DAC) perimeter to obtain dark-adapted static and dynamic rod function at multiple retinal locations, and compare these functional parameters between subjects with intermediate age-related macular degeneration (AMD) and normal controls. METHODS: Perimetric dark-adapted retinal sensitivities for the 505 and 620 nm stimuli across 7 retinal locations within the central 12° were repeatedly measured after exposing to a single photobleach in 22 intermediate AMD subjects and 8 controls. The sensitivities for each stimulus at 20 minutes after bleach and the sensitivity difference between the stimuli were used to determine static rod function. Sensitivities for the 505 nm stimulus at various times within the initial 20 minutes after bleach were used to estimate the rod criterion time to determine rod function dynamics. The static and dynamic rod functional parameters were compared between AMD and control eyes. RESULTS: Compared to the control eyes, AMD eyes had a reduction in retinal sensitivities for the 505 nm (P < 0.001) and 620 nm (P < 0.001) stimuli, a reduction in sensitivity difference (P < 0.001), and an increased in rod criterion time (P < 0.001). Region within the central 6° appeared to be the most defective and AMD eyes with reticular pseudodrusen (RPD) seemed to have worse function than eyes without RPD. CONCLUSIONS: It is feasible to use a DAC perimeter to study dark-adapted static and dynamic rod-mediated function at multiple retinal loci. Static and dynamic rod function were abnormal in intermediate AMD and more so in eyes with RPD, particularly within the central 6° retina.
Authors: Maximilian Pfau; Moritz Lindner; Martin Gliem; Julia S Steinberg; Sarah Thiele; Robert P Finger; Monika Fleckenstein; Frank G Holz; Steffen Schmitz-Valckenberg Journal: Eye (Lond) Date: 2018-08-01 Impact factor: 3.775
Authors: Quan Findlay; Andrew I Jobling; Kirstan A Vessey; Ursula Greferath; Joanna A Phipps; Robyn H Guymer; Erica L Fletcher Journal: Eye (Lond) Date: 2018-03-09 Impact factor: 3.775
Authors: Niklas Domdei; Lennart Domdei; Jenny L Reiniger; Michael Linden; Frank G Holz; Austin Roorda; Wolf M Harmening Journal: Biomed Opt Express Date: 2017-12-08 Impact factor: 3.732
Authors: Brett G Jeffrey; Oliver J Flynn; Laryssa A Huryn; Maximilian Pfau; Catherine A Cukras Journal: Invest Ophthalmol Vis Sci Date: 2022-06-01 Impact factor: 4.925
Authors: Jason Charng; Rose Tan; Chi D Luu; Sam Sadigh; Dwight Stambolian; Robyn H Guymer; Samuel G Jacobson; Artur V Cideciyan Journal: Invest Ophthalmol Vis Sci Date: 2017-10-01 Impact factor: 4.799
Authors: Julia S Steinberg; Marlene Saßmannshausen; Maximilian Pfau; Monika Fleckenstein; Robert P Finger; Frank G Holz; Steffen Schmitz-Valckenberg Journal: Transl Vis Sci Technol Date: 2017-07-13 Impact factor: 3.283
Authors: Lea D Bennett; Martin Klein; Kirsten G Locke; Kelly Kiser; David G Birch Journal: Transl Vis Sci Technol Date: 2017-08-09 Impact factor: 3.283