OBJECTIVES: There have been recent studies evaluating brain magnetic resonance imaging changes in patients with normal renal function, after intravenous administration of gadolinium-based contrast agents (GBCAs). Their findings were supported by histological evidence as well and brought a new vision concerning what needs to be learned to provide better patient care. In this report, we aim to present brain magnetic resonance imaging changes after intrathecal administration of a linear ionic agent (gadopentetate dimeglumine). MATERIALS AND METHODS: We evaluated hyperintensities in the deep nuclei of the brain in 6 patients with normal renal function after intrathecal administration of a linear ionic GBCA, without other confounding intravenous GBCA administrations. For visual analysis, T1 signal hyperintensity of the globus pallidus (GP), putamen, pons, and dentate nucleus (DN) were scored on a 4-point scale. For quantitative analysis, using the unenhanced T1-weighted images oval regions of interests were placed within the DN, central pons, GP, and thalamus on different image slice positions. RESULTS: On visual analysis, 5 patients had T1 signal hyperintensity of the DN and GP, whereas the DN/pons signal intensity and the GP/thalamus signal intensity were found to be increased in all 6. CONCLUSIONS: This observation not only adds to our fund of knowledge concerning biodistribution and pharmacokinetics of those agents, but also raises the question of a possible association with the glymphatic pathway.
OBJECTIVES: There have been recent studies evaluating brain magnetic resonance imaging changes in patients with normal renal function, after intravenous administration of gadolinium-based contrast agents (GBCAs). Their findings were supported by histological evidence as well and brought a new vision concerning what needs to be learned to provide better patient care. In this report, we aim to present brain magnetic resonance imaging changes after intrathecal administration of a linear ionic agent (gadopentetate dimeglumine). MATERIALS AND METHODS: We evaluated hyperintensities in the deep nuclei of the brain in 6 patients with normal renal function after intrathecal administration of a linear ionic GBCA, without other confounding intravenous GBCA administrations. For visual analysis, T1 signal hyperintensity of the globus pallidus (GP), putamen, pons, and dentate nucleus (DN) were scored on a 4-point scale. For quantitative analysis, using the unenhanced T1-weighted images oval regions of interests were placed within the DN, central pons, GP, and thalamus on different image slice positions. RESULTS: On visual analysis, 5 patients had T1 signal hyperintensity of the DN and GP, whereas the DN/pons signal intensity and the GP/thalamus signal intensity were found to be increased in all 6. CONCLUSIONS: This observation not only adds to our fund of knowledge concerning biodistribution and pharmacokinetics of those agents, but also raises the question of a possible association with the glymphatic pathway.
Authors: T Dobrocky; A Winklehner; P S Breiding; L Grunder; G Peschi; L Häni; P J Mosimann; M Branca; J Kaesmacher; P Mordasini; A Raabe; C T Ulrich; J Beck; J Gralla; E I Piechowiak Journal: AJNR Am J Neuroradiol Date: 2020-06-18 Impact factor: 3.825
Authors: Aida Kiviniemi; Maria Gardberg; Paul Ek; Janek Frantzén; Johan Bobacka; Heikki Minn Journal: Neuroradiology Date: 2019-02-02 Impact factor: 2.804
Authors: Wenyu Deng; Crystal Liu; Carlos Parra; Jeffrey R Sims; Muneeb A Faiq; Anoop Sainulabdeen; Hana Song; Kevin C Chan Journal: Quant Imaging Med Surg Date: 2020-01
Authors: G Barisano; B Bigjahan; S Metting; S Cen; L Amezcua; A Lerner; A W Toga; M Law Journal: AJNR Am J Neuroradiol Date: 2019-07-25 Impact factor: 3.825