Literature DB >> 27752841

Antioxidant and antigenotoxic potencies of Sempervivum armenum on human lymphocytes in vitro.

Serap Sunar1, Mustafa Anar2, Meryem Sengul3, Guleray Agar3.   

Abstract

In this research, the genotoxic and antigenotoxic effects of methanol extract of Sempervivum armenum (MSA) were studied using micronucleus (MN) test and sister chromatid exchange (SCE) test systems in cultured human peripheral blood cells. According to the SCE and MN tests results, MSA reduced the genotoxic effects of aflatoxin B1. In order to explain the reason for the antigenotoxic effects of MSA, antioxidants levels were determined. Cotreatments of 5, 10, 20 mg/mL concentrations of MSA with aflatoxin B1 decreased the frequencies of SCE, MN and the malondialdehyde level and increased the amount of superoxide dismutase, glutathione and glutathione peroxidase which were decreased by aflatoxin. The results of this experiment showed that MSA has strong antioxidative and antigenotoxic effects and this antigenotoxic activities of MSA can be due to the antioxidant activities.

Entities:  

Keywords:  Aflatoxin B1; Antigenotoxicity; Antioxidant; Sempervivum armenum

Year:  2016        PMID： 27752841      PMCID： PMC5101305          DOI： 10.1007/s10616-016-0030-y

Source DB:  PubMed          Journal:  Cytotechnology        ISSN： 0920-9069            Impact factor:   2.058


  13 in total

1.  Exposure assessment of mycotoxins in cow's milk in Argentina.

Authors:  M L Signorini; M Gaggiotti; A Molineri; C A Chiericatti; M L Zapata de Basílico; J C Basílico; M Pisani
Journal:  Food Chem Toxicol       Date:  2011-10-10       Impact factor: 6.023

2.  Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction.

Authors:  H Ohkawa; N Ohishi; K Yagi
Journal:  Anal Biochem       Date:  1979-06       Impact factor: 3.365

3.  Preliminary screening of some traditional zulu medicinal plants for anti-inflammatory and anti-microbial activities.

Authors:  J Lin; A R Opoku; M Geheeb-Keller; A D Hutchings; S E Terblanche; A K Jäger; J van Staden
Journal:  J Ethnopharmacol       Date:  1999-12-15       Impact factor: 4.360

4.  Enzymic method for quantitative determination of nanogram amounts of total and oxidized glutathione: applications to mammalian blood and other tissues.

Authors:  F Tietze
Journal:  Anal Biochem       Date:  1969-03       Impact factor: 3.365

5.  A simple method for clinical assay of superoxide dismutase.

Authors:  Y Sun; L W Oberley; Y Li
Journal:  Clin Chem       Date:  1988-03       Impact factor: 8.327

6.  Studies on the quantitative and qualitative characterization of erythrocyte glutathione peroxidase.

Authors:  D E Paglia; W N Valentine
Journal:  J Lab Clin Med       Date:  1967-07

7.  Tentative identification of polyphenols in Sempervivum tectorum and assessment of the antimicrobial activity of Sempervivum L.

Authors:  V Abram; M Donko
Journal:  J Agric Food Chem       Date:  1999-02       Impact factor: 5.279

8.  Effect of buthionine sulfoximine, a synthesis inhibitor of the antioxidant glutathione, on the murine nigrostriatal neurons.

Authors:  J K Andersen; J Q Mo; D G Hom; F Y Lee; P Harnish; R W Hamill; T H McNeill
Journal:  J Neurochem       Date:  1996-11       Impact factor: 5.372

9.  The production of micronuclei from chromosome aberrations in irradiated cultures of human lymphocytes.

Authors:  P I Countryman; J A Heddle
Journal:  Mutat Res       Date:  1976-12       Impact factor: 2.433

10.  The antioxidant and antigenotoxic potential of methanol extract of Cladonia foliacea (Huds.) Willd.

Authors:  Mustafa Anar; Furkan Orhan; Lokman Alpsoy; Medine Gulluce; Ali Aslan; Guleray Agar
Journal:  Toxicol Ind Health       Date:  2013-11-05       Impact factor: 2.273
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.