Literature DB >> 27752830

A Paradox: α-Klotho Levels and Smoking Intensity.

Zoraida Verde1, Jose M Rodríguez González-Moro2, Luis M Chicharro3, Luis Reinoso-Barbero4,5, Fernando Bandrés6, Félix Gómez-Gallego7, Catalina Santiago7.   

Abstract

Reports regarding smoking differences in α-klotho expression have provided conflicting results. In the current study we focused on the influence of smoking intensity to serum levels of the aging molecule α-klotho in healthy smokers. 40 middle aged healthy smokers without airway obstruction or restriction were selected for the analysis. Serum levels of soluble α-klotho were significantly higher in heavy smokers (P < 0.001). These results are in agreement with the possibility that α-klotho acts as anti-inflammatory molecule and strengthen the hypothesis that an increase of serum levels of α-klotho might be a compensatory response to smoking stress in healthy population.

Entities:  

Keywords:  Aging; Cigarettes per day; Healthy smokers; Packs year smoked; α-Klotho

Mesh：

Substances：

Year:  2016        PMID： 27752830     DOI： 10.1007/s00408-016-9944-6

Source DB:  PubMed          Journal:  Lung        ISSN： 0341-2040            Impact factor:   2.584


  19 in total

Review 1.  Oxidants/antioxidants and COPD.

Authors:  W MacNee
Journal:  Chest       Date:  2000-05       Impact factor: 9.410

2.  α-Klotho protects against oxidative damage in pulmonary epithelia.

Authors:  Priya Ravikumar; Jianfeng Ye; Jianning Zhang; Sydney N Pinch; Ming Chang Hu; Makoto Kuro-o; Connie C W Hsia; Orson W Moe
Journal:  Am J Physiol Lung Cell Mol Physiol       Date:  2014-07-25       Impact factor: 5.464

3.  Soluble extracellular Klotho decreases sensitivity to cigarette smoke induced cell death in human lung epithelial cells.

Authors:  David J Blake; Caitlyn M Reese; Mario Garcia; Elizabeth A Dahlmann; Alexander Dean
Journal:  Toxicol In Vitro       Date:  2015-06-19       Impact factor: 3.500

4.  Mutation of the mouse klotho gene leads to a syndrome resembling ageing.

Authors:  M Kuro-o; Y Matsumura; H Aizawa; H Kawaguchi; T Suga; T Utsugi; Y Ohyama; M Kurabayashi; T Kaname; E Kume; H Iwasaki; A Iida; T Shiraki-Iida; S Nishikawa; R Nagai; Y I Nabeshima
Journal:  Nature       Date:  1997-11-06       Impact factor: 49.962

5.  Infection and smoking are associated with decreased plasma concentration of the anti-aging protein, α-klotho.

Authors:  Jennifer Lam-Rachlin; Roberto Romero; Steven J Korzeniewski; Alyse G Schwartz; Piya Chaemsaithong; Edgar Hernandez-Andrade; Zhong Dong; Lami Yeo; Sonia S Hassan; Tinnakorn Chaiworapongsa
Journal:  J Perinat Med       Date:  2013-09-01       Impact factor: 1.901

6.  Interaction between smoking and the interleukin-6 gene affects systemic levels of inflammatory biomarkers.

Authors:  Jordi Sunyer; F Forastiere; J Pekkanen; E Plana; M Kolz; R Pistelli; B Jacquemin; I Brüske-Hohlfeld; Ch Pitsavos; T Bellander; W Koenig; A Peters
Journal:  Nicotine Tob Res       Date:  2009-10-13       Impact factor: 4.244

7.  Down-Regulation of Soluble α-Klotho is Associated with Reduction in Serum Irisin Levels in Chronic Obstructive Pulmonary Disease.

Authors:  Yuko Kureya; Hiroshi Kanazawa; Naoki Ijiri; Yoshihiro Tochino; Tetsuya Watanabe; Kazuhisa Asai; Kazuto Hirata
Journal:  Lung       Date:  2016-05-02       Impact factor: 2.584

Review 8.  Pathogenesis of chronic obstructive pulmonary disease.

Authors:  Rubin M Tuder; Irina Petrache
Journal:  J Clin Invest       Date:  2012-08-01       Impact factor: 14.808

9.  Klotho and smoking--An interplay influencing the skeletal muscle function deficits that occur in COPD.

Authors:  M S Patel; A V Donaldson; A Lewis; S A Natanek; J Y Lee; Y M Andersson; G Haji; S G Jackson; B J Bolognese; J P Foley; P L Podolin; P L B Bruijnzeel; N Hart; N S Hopkinson; W D-C Man; P R Kemp; M I Polkey
Journal:  Respir Med       Date:  2016-02-15       Impact factor: 3.415

10.  Smoking accelerates aging of the small airway epithelium.

Authors:  Matthew S Walters; Bishnu P De; Jacqueline Salit; Lauren J Buro-Auriemma; Timothy Wilson; Allison M Rogalski; Lindsay Lief; Neil R Hackett; Michelle R Staudt; Ann E Tilley; Ben-Gary Harvey; Robert J Kaner; Jason G Mezey; Beth Ashbridge; Malcolm A S Moore; Ronald G Crystal
Journal:  Respir Res       Date:  2014-09-24
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  1 in total

1.  Comparative transcriptomics in human COPD reveals dysregulated genes uniquely expressed in ferrets.

Authors:  Shah S Hussain; Yvonne J K Edwards; Emily Falk Libby; Denise Stanford; Stephen A Byzek; Don D Sin; Merry-Lynn McDonald; S Vamsee Raju; Steven M Rowe
Journal:  Respir Res       Date:  2022-10-10
  1 in total

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