Fernando Guerrero-Romero1, Rafael Villalobos-Molina2, J Rafael Jiménez-Flores2, Luis E Simental-Mendia1, René Méndez-Cruz2, Miguel Murguía-Romero2, Martha Rodríguez-Morán3. 1. Biomedical Research Unit, Mexican Social Security Institute, Durango, Mexico, and Research Group on Diabetes and Chronic Illnesses, Durango, Mexico. 2. Faculty of Higher Studies Iztacala, National Autonomous University of Mexico (UNAM), Mexico City, Mexico. 3. Biomedical Research Unit, Mexican Social Security Institute, Durango, Mexico, and Research Group on Diabetes and Chronic Illnesses, Durango, Mexico. Electronic address: rodriguez.moran.martha@gmail.com.
Abstract
BACKGROUND AND AIMS: Although the Glucose and Triglyceride levels (TyG) index is useful for identification of insulin resistance (IR) in different ethnic groups, it has not been evaluated in young adults. We undertook this study to evaluate the TyG index as a diagnostic test for IR in young adults. METHODS: A total of 5,538 healthy young adults, 3,795 (68.5%) non-pregnant women and 1,743 (31.5%) men, with an average age of 19.2 ± 1.4 years, were enrolled in a population-based cross-sectional study. To estimate diagnostic characteristics of the TyG index, a randomized subsample of the target population (n = 75) was under euglycemic-hyperinsulinemic clamp test. Using the cutoff values obtained in the clamp study, the diagnostic concordance between TyG index and HOMA-IR was evaluated in the overall population. The TyG index was calculated as the Ln[fasting triglycerides (mg/dL) × fasting glucose (mg/dL)]/2. RESULTS: Normal weight, overweight, and obesity were identified in 3,632 (65.6%), 1,355 (24.5%), and 551 (9.9%) participants. A total of 346 (9.1%) men and 278 (15.9%) women exhibited IR. The best cutoff value of TyG index for diagnosis of IR was 4.55 (sensitivity 0.687, negative predictive value (NPV) 0.844, and negative likelihood ratio (NLR) 0.47) for women and 4.68 (sensitivity 0.673, NPV 0.900, and NLR 0.45) for men. In normal-weight individuals the diagnostic concordance between TyG index and HOMA-IR was 0.934 and 0.915, in the overweight subjects was 0.908 and 0.895 and, in the obese participants 0.916 and 0.950, for men and women, respectively. CONCLUSIONS: TyG index may be useful for screening IR in young adults.
BACKGROUND AND AIMS: Although the Glucose and Triglyceride levels (TyG) index is useful for identification of insulin resistance (IR) in different ethnic groups, it has not been evaluated in young adults. We undertook this study to evaluate the TyG index as a diagnostic test for IR in young adults. METHODS: A total of 5,538 healthy young adults, 3,795 (68.5%) non-pregnant women and 1,743 (31.5%) men, with an average age of 19.2 ± 1.4 years, were enrolled in a population-based cross-sectional study. To estimate diagnostic characteristics of the TyG index, a randomized subsample of the target population (n = 75) was under euglycemic-hyperinsulinemic clamp test. Using the cutoff values obtained in the clamp study, the diagnostic concordance between TyG index and HOMA-IR was evaluated in the overall population. The TyG index was calculated as the Ln[fasting triglycerides (mg/dL) × fasting glucose (mg/dL)]/2. RESULTS: Normal weight, overweight, and obesity were identified in 3,632 (65.6%), 1,355 (24.5%), and 551 (9.9%) participants. A total of 346 (9.1%) men and 278 (15.9%) women exhibited IR. The best cutoff value of TyG index for diagnosis of IR was 4.55 (sensitivity 0.687, negative predictive value (NPV) 0.844, and negative likelihood ratio (NLR) 0.47) for women and 4.68 (sensitivity 0.673, NPV 0.900, and NLR 0.45) for men. In normal-weight individuals the diagnostic concordance between TyG index and HOMA-IR was 0.934 and 0.915, in the overweight subjects was 0.908 and 0.895 and, in the obeseparticipants 0.916 and 0.950, for men and women, respectively. CONCLUSIONS: TyG index may be useful for screening IR in young adults.
Authors: Min Kyung Kim; Chul Woo Ahn; Shinae Kang; Ji Sun Nam; Kyung Rae Kim; Jong Suk Park Journal: Cardiovasc Diabetol Date: 2017-08-23 Impact factor: 9.951
Authors: Tomasz Miazgowski; Robert Kucharski; Marta Sołtysiak; Aleksandra Taszarek; Bartosz Miazgowski; Krystyna Widecka Journal: PLoS One Date: 2017-07-06 Impact factor: 3.240
Authors: Juan Salazar; Valmore Bermúdez; María Calvo; Luis Carlos Olivar; Eliana Luzardo; Carla Navarro; Heysa Mencia; María Martínez; José Rivas-Ríos; Sandra Wilches-Durán; Marcos Cerda; Modesto Graterol; Rosemily Graterol; Carlos Garicano; Juan Hernández; Joselyn Rojas Journal: F1000Res Date: 2017-08-07