Literature DB >> 27750091

Hedgehog signaling in the stomach.

Daniel Konstantinou1, Nina Bertaux-Skeirik1, Yana Zavros2.   

Abstract

The Hedgehog (Hh) signaling pathway not only plays a key part in controlling embryonic development, but in the adult stomach governs important cellular events such as epithelial cell differentiation, proliferation, gastric disease, and regeneration. In particular, Sonic Hedgehog (Shh) signaling has been well studied for its role in gastric physiology and pathophysiology. Shh is secreted from the gastric parietal cells and contributes to the regeneration of the epithelium in response to injury, or the development of gastritis during Helicobacter pylori infection. Dysregulation of the Shh signaling pathway leads to the disruption of gastric differentiation, loss of gastric acid secretion and the development of cancer. In this chapter, we will review the most recent findings that reveal the role of Shh as a regulator of gastric physiology, regeneration, and disease.
Copyright © 2016 Elsevier Ltd. All rights reserved.

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Year:  2016        PMID： 27750091      PMCID： PMC5154826          DOI： 10.1016/j.coph.2016.09.003

Source DB:  PubMed          Journal:  Curr Opin Pharmacol        ISSN： 1471-4892            Impact factor:   5.547


  47 in total

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Authors:  Junichi Ikenouchi; Miho Matsuda; Mikio Furuse; Shoichiro Tsukita
Journal:  J Cell Sci       Date:  2003-03-26       Impact factor: 5.285

Review 2.  Hedgehog signalling in gut development, physiology and cancer.

Authors:  Juanita L Merchant
Journal:  J Physiol       Date:  2011-12-05       Impact factor: 5.182

3.  Interleukin-1beta promotes gastric atrophy through suppression of Sonic Hedgehog.

Authors:  Meghna Waghray; Yana Zavros; Milena Saqui-Salces; Mohamad El-Zaatari; C Bharath Alamelumangapuram; Andrea Todisco; Kathryn A Eaton; Juanita L Merchant
Journal:  Gastroenterology       Date:  2009-10-31       Impact factor: 22.682

Review 4.  Control of stem cells and cancer stem cells by Hedgehog signaling: pharmacologic clues from pathway dissection.

Authors:  Sonia Coni; Paola Infante; Alberto Gulino
Journal:  Biochem Pharmacol       Date:  2012-11-10       Impact factor: 5.858

Review 5.  Small molecule inhibitors of the hedgehog signaling pathway for the treatment of cancer.

Authors:  Jeong In Yun; Hyoung Rae Kim; Haeil Park; Sang Kyum Kim; Jongkook Lee
Journal:  Arch Pharm Res       Date:  2012-09-01       Impact factor: 4.946

Review 6.  Management of gastric adenocarcinoma.

Authors:  P Khosravi Shahi; V M Díaz Muñoz de la Espada; P García Alfonso; S Encina García; Y Izarzugaza Perón; J L Arranz Cozar; B Hernández Marín; G Pérez Manga
Journal:  Clin Transl Oncol       Date:  2007-07       Impact factor: 3.405

7.  Widespread requirement for Hedgehog ligand stimulation in growth of digestive tract tumours.

Authors:  David M Berman; Sunil S Karhadkar; Anirban Maitra; Rocio Montes De Oca; Meg R Gerstenblith; Kimberly Briggs; Antony R Parker; Yutaka Shimada; James R Eshleman; D Neil Watkins; Philip A Beachy
Journal:  Nature       Date:  2003-09-14       Impact factor: 49.962

Review 8.  Communicating with Hedgehogs.

Authors:  Joan E Hooper; Matthew P Scott
Journal:  Nat Rev Mol Cell Biol       Date:  2005-04       Impact factor: 94.444

9.  Gli2 and Gli3 localize to cilia and require the intraflagellar transport protein polaris for processing and function.

Authors:  Courtney J Haycraft; Boglarka Banizs; Yesim Aydin-Son; Qihong Zhang; Edward J Michaud; Bradley K Yoder
Journal:  PLoS Genet       Date:  2005-10-28       Impact factor: 5.917

10.  De-regulation of the sonic hedgehog pathway in the InsGas mouse model of gastric carcinogenesis.

Authors:  M El-Zaatari; A Tobias; A M Grabowska; R Kumari; P J Scotting; P Kaye; J Atherton; P A Clarke; D G Powe; S A Watson
Journal:  Br J Cancer       Date:  2007-05-15       Impact factor: 7.640
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  16 in total

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Authors:  Ramon U Jin; Jason C Mills
Journal:  Dig Dis Sci       Date:  2018-08       Impact factor: 3.199

Review 2.  The immune microenvironment in gastric adenocarcinoma.

Authors:  Yana Zavros; Juanita L Merchant
Journal:  Nat Rev Gastroenterol Hepatol       Date:  2022-03-14       Impact factor: 73.082

Review 3.  Metaplasia: tissue injury adaptation and a precursor to the dysplasia-cancer sequence.

Authors:  Veronique Giroux; Anil K Rustgi
Journal:  Nat Rev Cancer       Date:  2017-09-01       Impact factor: 60.716

Review 4.  Hedgehog Signaling Links Chronic Inflammation to Gastric Cancer Precursor Lesions.

Authors:  Juanita L Merchant; Lin Ding
Journal:  Cell Mol Gastroenterol Hepatol       Date:  2017-01-16

Review 5.  Hedgehog Signaling: An Achilles' Heel in Cancer.

Authors:  Madiha Niyaz; Mosin S Khan; Syed Mudassar
Journal:  Transl Oncol       Date:  2019-07-25       Impact factor: 4.243

6.  LIM homeodomain transcription factor Isl1 affects urethral epithelium differentiation and apoptosis via Shh.

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Journal:  Cell Death Dis       Date:  2019-09-26       Impact factor: 8.469

7.  Prognostic value of Kinesin-4 family genes mRNA expression in early-stage pancreatic ductal adenocarcinoma patients after pancreaticoduodenectomy.

Authors:  Quanfa Han; Chuangye Han; Xiwen Liao; Ketuan Huang; Xiangkun Wang; Tingdong Yu; Chengkun Yang; Guanghui Li; Bowen Han; Guangzhi Zhu; Zhengqian Liu; Xin Zhou; Junqi Liu; Hao Su; Liming Shang; Tao Peng; Xinping Ye
Journal:  Cancer Med       Date:  2019-09-06       Impact factor: 4.452

8.  Iqgap3-Ras axis drives stem cell proliferation in the stomach corpus during homoeostasis and repair.

Authors:  Junichi Matsuo; Daisuke Douchi; Khine Myint; Naing Naing Mon; Akihiro Yamamura; Kazuyoshi Kohu; Dede Liana Heng; Sabirah Chen; Nur Astiana Mawan; Napat Nuttonmanit; Ying Li; Supriya Srivastava; Shamaine Wei Ting Ho; Nicole Yee Shin Lee; Hong Kai Lee; Makoto Adachi; Atsushi Tamura; Jinmiao Chen; Henry Yang; Ming Teh; Jimmy Bok-Yan So; Wei Peng Yong; Patrick Tan; Khay Guan Yeoh; Linda Shyue Huey Chuang; Sachiko Tsukita; Yoshiaki Ito
Journal:  Gut       Date:  2020-12-08       Impact factor: 23.059

Review 9.  Hedgehog signaling pathway in colorectal cancer: function, mechanism, and therapy.

Authors:  Chuanqing Wu; Xiaojie Zhu; Weizhen Liu; Tuo Ruan; Kaixiong Tao
Journal:  Onco Targets Ther       Date:  2017-06-30       Impact factor: 4.147

Review 10.  Understanding the Hedgehog Signaling Pathway in Acute Myeloid Leukemia Stem Cells: A Necessary Step toward a Cure.

Authors:  Daniel Lainez-González; Juana Serrano-López; Juan Manuel Alonso-Domínguez
Journal:  Biology (Basel)       Date:  2021-03-24
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