Christian H Roux1, Violaine Foltz2, Emmanuel Maheu3, Gabriel Baron4, Frederique Gandjbakhch2, Cédric Lukas5, Daniel Wendling6, Damien Loeuille7, Pierre Lafforgue8, Liana Euler-Ziegler9, Pascal Richette10, Xavier Chevalier11. 1. Rheumatology Department, CHU Archet 1, LAMHESS EA6309, University of Nice Sophia Antipolis, France. roux.c2@chu-nice.fr. 2. Rheumatology Department, University of Paris VI, CHU Pitié Salpétrière, Paris, France. 3. Rheumatology Department, Saint Antoine Hospital, AP-HP, Paris, France. 4. Epidemiology and Biostatistics Department, INSERM, U738, Bichat-Claude Bernard Hospital Group, Paris, France. 5. Rheumatology Department, Lapeyronie Hospital, Montpellier, France. 6. Rheumatology Department, CHRU Besançon, France. 7. Rheumatology Department, CHU Nancy-Brabois, Nancy, France. 8. Rheumatology Department South, CHU Sainte Marguerite, Marseille, France. 9. Rheumatology Department, CHU Archet 1, LAMHESS EA6309, University of Nice Sophia Antipolis, France. 10. Rheumatology Department, Lariboisiére Hospital, Paris, France. 11. Rheumatology Department, Henri Mondor Hospital, Creteil, France.
Abstract
OBJECTIVES: To explore the relationship between clinical findings, biologic biomarkers, conventional radiography and MRI in patients with painful hand OA. METHODS: The following patient baseline data from the DORA study (evaluating anti-TNF-α agents against painful hand OA) were used: clinical assessment (pain, swelling, stiffness and function: Dreiser functional hand index [FIHOA] and Cochin hand functional scale [CHFS]); measurement of biomarkers (cartilage oligomeric matrix protein (COMP), type IIA collagen N-propeptid (PIINP), hyaluronic acid (HA), ultrasensitive C-reactive protein (usCRP), tumour necrosis factor (TNF), interleukin (IL)-6, IL-1β and urinary CTXII); radiological staging (Verbruggen, Kallman, Kellgren-Lawrence); anatomical evaluation by contrast-enhanced MRI of proximal and distal interphalangeal joints of dominant hand. Associations between clinical, biomarker and imaging findings were assessed using the Spearman correlation coefficient and test. RESULTS: 18 patients were recruited, and 144 joints studied. A correlation was found between clinical features (pain, FIHOA, CHFS) and the Verbruggen score (respectively: p=0.05, r=0.47; p=0.05, r=0.48; p=0.05, r=0.48). Serum IL-1 level was strongly associated with loss of function (FIHOA: p=0.02, r=-0.73; CHFS: p=0.01, r=-0.76) and radiological erosions (p=0.03, r=0.7) as with urinary CTX2. A significant association was found between MRI osteophytes and usCRP (p=0.0026). MRI and radiological features were significantly correlated except for synovitis and bone marrow lesions. CONCLUSIONS: MRI synovitis was not correlated with radiological scores, clinical or biologic markers of inflammation. There was a strong correlation between other MRI features and radiological scores. Serum IL-1 level was associated with structural damage and function.
OBJECTIVES: To explore the relationship between clinical findings, biologic biomarkers, conventional radiography and MRI in patients with painful hand OA. METHODS: The following patient baseline data from the DORA study (evaluating anti-TNF-α agents against painful hand OA) were used: clinical assessment (pain, swelling, stiffness and function: Dreiser functional hand index [FIHOA] and Cochin hand functional scale [CHFS]); measurement of biomarkers (cartilage oligomeric matrix protein (COMP), type IIA collagen N-propeptid (PIINP), hyaluronic acid (HA), ultrasensitive C-reactive protein (usCRP), tumour necrosis factor (TNF), interleukin (IL)-6, IL-1β and urinary CTXII); radiological staging (Verbruggen, Kallman, Kellgren-Lawrence); anatomical evaluation by contrast-enhanced MRI of proximal and distal interphalangeal joints of dominant hand. Associations between clinical, biomarker and imaging findings were assessed using the Spearman correlation coefficient and test. RESULTS: 18 patients were recruited, and 144 joints studied. A correlation was found between clinical features (pain, FIHOA, CHFS) and the Verbruggen score (respectively: p=0.05, r=0.47; p=0.05, r=0.48; p=0.05, r=0.48). Serum IL-1 level was strongly associated with loss of function (FIHOA: p=0.02, r=-0.73; CHFS: p=0.01, r=-0.76) and radiological erosions (p=0.03, r=0.7) as with urinary CTX2. A significant association was found between MRI osteophytes and usCRP (p=0.0026). MRI and radiological features were significantly correlated except for synovitis and bone marrow lesions. CONCLUSIONS: MRI synovitis was not correlated with radiological scores, clinical or biologic markers of inflammation. There was a strong correlation between other MRI features and radiological scores. Serum IL-1 level was associated with structural damage and function.
Authors: Shanshan Li; Ann V Schwartz; Michael P LaValley; Na Wang; Nancy Desai; Xianbang Sun; Tuhina Neogi; Michael Nevitt; Cora E Lewis; Ali Guermazi; Frank Roemer; Neil Segal; David Felson Journal: Arthritis Rheumatol Date: 2020-05-28 Impact factor: 10.995
Authors: Marta P Silvestre; Ana M Rodrigues; Helena Canhão; Cláudia Marques; Diana Teixeira; Conceição Calhau; Jaime Branco Journal: Nutrients Date: 2020-11-12 Impact factor: 5.717