Literature DB >> 27748489

Biologically active γ-lactams: synthesis and natural sources.

J Caruano1, G G Muccioli2, R Robiette3.   

Abstract

The γ-lactam moiety is present in a large number of natural and non-natural biologically active compounds. The range of biological activities covered by these compounds is very broad. Functionalized γ-lactams are thus of high interest and have great potential in medicinal chemistry. This review provides a description of the title compounds by focusing on their synthesis, natural sources and biological activities.

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Year:  2016        PMID： 27748489     DOI： 10.1039/c6ob01349j

Source DB:  PubMed          Journal:  Org Biomol Chem        ISSN： 1477-0520            Impact factor:   3.876


  29 in total

1.  Enantioselective Synthesis of γ-Lactams by Lewis Base Catalyzed Sulfenoamidation of Alkenes.

Authors:  Jesse L Panger; Scott E Denmark
Journal:  Org Lett       Date:  2019-12-20       Impact factor: 6.005

2.  H· Transfer-Initiated Synthesis of γ-Lactams: Interpretation of Cycloisomerization and Hydrogenation Ratios.

Authors:  Chris Lorenc; Hunter B Vibbert; Chengbo Yao; Jack R Norton; Michael Rauch
Journal:  ACS Catal       Date:  2019-10-09       Impact factor: 13.084

3.  Catalytic Asymmetric Synthesis of Trifluoromethylated γ-Amino Acids through the Umpolung Addition of Trifluoromethyl Imines to Carboxylic Acid Derivatives.

Authors:  Bin Hu; Li Deng
Journal:  Angew Chem Int Ed Engl       Date:  2018-01-18       Impact factor: 15.336

4.  Remote, Late-Stage Oxidation of Aliphatic C-H Bonds in Amide-Containing Molecules.

Authors:  Takeshi Nanjo; Emilio C de Lucca; M Christina White
Journal:  J Am Chem Soc       Date:  2017-10-04       Impact factor: 15.419

5.  Cu-Catalyzed Three-Component Carboamination of Alkenes.

Authors:  Samuel N Gockel; Travis L Buchanan; Kami L Hull
Journal:  J Am Chem Soc       Date:  2017-12-28       Impact factor: 15.419

6.  Synthesis of Structurally Diverse 3-, 4-, 5-, and 6-Membered Heterocycles from Diisopropyl Iminomalonates and Soft C-Nucleophiles.

Authors:  Padmanabha V Kattamuri; Urmibhusan Bhakta; Surached Siriwongsup; Doo-Hyun Kwon; Lawrence B Alemany; Muhammed Yousufuddin; Daniel H Ess; László Kürti
Journal:  J Org Chem       Date:  2019-05-14       Impact factor: 4.354

7.  Nickel-Catalyzed Enantioselective Reductive Alkyl-Carbamoylation of Internal Alkenes.

Authors:  Xianqing Wu; Aneta Turlik; Baixue Luan; Feng He; Jingping Qu; K N Houk; Yifeng Chen
Journal:  Angew Chem Int Ed Engl       Date:  2022-07-25       Impact factor: 16.823

8.  Enantioselective Michael-Proton Transfer-Lactamization for Pyroglutamic Acid Derivatives: Synthesis of Dimethyl-(S,E)-5-oxo-3-styryl-1-tosylpyrrolidine-2,2-dicarboxylate.

Authors:  Christian M Chaheine; Conner J Song; Paul T Gladen; Daniel Romo
Journal:  Organic Synth       Date:  2021

9.  The Beta-Lactam Resistome Expressed by Aerobic and Anaerobic Bacteria Isolated from Human Feces of Healthy Donors.

Authors:  Rosalino Vázquez-López; Sandra Solano-Gálvez; Diego Abelardo Álvarez-Hernández; Jorge Alberto Ascencio-Aragón; Eduardo Gómez-Conde; Celia Piña-Leyva; Manuel Lara-Lozano; Tayde Guerrero-González; Juan Antonio González-Barrios
Journal:  Pharmaceuticals (Basel)       Date:  2021-06-03

10.  Tandem aza-Heck Suzuki and carbonylation reactions of O-phenyl hydroxamic ethers: complex lactams via carboamination.

Authors:  Run-Duo Gao; Scott A Shuler; Donald A Watson
Journal:  Chem Sci       Date:  2021-05-27       Impact factor: 9.825
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