Metabolic disturbances induced by organotins through subchronic treatment in chickens. Second communication: mineral metabolism.

4 organotin derivatives (tributyltin acid, dibutyltin chloride, triphenyltin chloride, and triphenyltinbis (diethyl) dithiophosphate) were tested through subchronic treatment in 19 days old chickens. Their effects upon mineral metabolism were studied through biochemical investigations in kidney, bone, and blood. Bone mineral disturbances (depletion of Ca/P ratio) induced Ca elimination in blood, immobilised as calcium urates in kidney, and also increased values for alkaline phosphatase, following tin accumulation in bone. Butyl and phenyltin chloride were more toxic than dithiophosphate, and the intensity of effects was proportionate to the dose.