Literature DB >> 2774708

Does the bacteremia observed in hemorrhagic shock have clinical significance? A study in germ-free animals.

B F Rush1, J A Redan, J J Flanagan, J B Heneghan, J Hsieh, T F Murphy, S Smith, G W Machiedo.   

Abstract

We have recently reported the rapid appearance of bacteria and endotoxin in the blood of rats and of trauma patients in the course of 30 minutes to 2 hours of hemorrhagic shock. The current study was designed to determine the effect of this bacteremia and endotoxemia on survival. Thirty-three conventional (C:group 1) and 36 germ-free (GF:group 2) Sprague Dawley rats were subjected to our previously described model of treated hemorrhagic shock. Survival in the GF group was significantly better than the C group at 24, 48, and 72 hours after shock. Endotoxin levels were elevated in 88% of C group during shock and in 28% of GF group. The gut of the GF animal contains endotoxin (26 ng/gm of stool) as does the sterile food supply (393 ng/gm of rat chow).

Entities:  

Mesh：

Substances：

Year:  1989        PMID： 2774708      PMCID： PMC1358000          DOI： 10.1097/00000658-198909000-00010

Source DB:  PubMed          Journal:  Ann Surg        ISSN： 0003-4932            Impact factor:   12.969


  29 in total

1.  Biological implications of intestinal endotoxins.

Authors:  H A RAVIN; J FINE
Journal:  Fed Proc       Date:  1962 Jan-Feb

2.  A systematic study of host defense processes in badly injured patients.

Authors:  H C Polk; C D George; S R Wellhausen; K Cost; P R Davidson; M P Regan; A P Borzotta
Journal:  Ann Surg       Date:  1986-09       Impact factor: 12.969

3.  The gut as source of sepsis after hemorrhagic shock.

Authors:  A J Sori; B F Rush; T W Lysz; S Smith; G W Machiedo
Journal:  Am J Surg       Date:  1988-02       Impact factor: 2.565

4.  Delayed immune dysfunction following hemorrhagic shock and resuscitation.

Authors:  M A Croce; T C Fabian; K A Kudsk; L L Trenthem; C R Patterson
Journal:  Am Surg       Date:  1988-12       Impact factor: 0.688

5.  Remote organ failure: a valid sign of occult intra-abdominal infection.

Authors:  H C Polk; C L Shields
Journal:  Surgery       Date:  1977-03       Impact factor: 3.982

6.  Endotoxemia and bacteremia during hemorrhagic shock. The link between trauma and sepsis?

Authors:  B F Rush; A J Sori; T F Murphy; S Smith; J J Flanagan; G W Machiedo
Journal:  Ann Surg       Date:  1988-05       Impact factor: 12.969

7.  Occurrence of bacteremia during and after hemorrhagic shock.

Authors:  J M Koziol; B F Rush; S M Smith; G W Machiedo
Journal:  J Trauma       Date:  1988-01

8.  Depressed interferon gamma production and monocyte HLA-DR expression after severe injury.

Authors:  D H Livingston; S H Appel; S R Wellhausen; G Sonnenfeld; H C Polk
Journal:  Arch Surg       Date:  1988-11

9.  Posttraumatic complications and inflammatory mediators.

Authors:  J K Nuytinck; J A Goris; H Redl; G Schlag; P J van Munster
Journal:  Arch Surg       Date:  1986-08

10.  Biochemical and morphologic changes in hepatocytes from the shock injured liver.

Authors:  M J Donohoe; B F Rush; G W Machiedo; D J Barillo; T F Murphy
Journal:  Surg Gynecol Obstet       Date:  1986-04
View more
  12 in total

Review 1.  The microbiome and critical illness.

Authors:  Robert P Dickson
Journal:  Lancet Respir Med       Date:  2015-12-12       Impact factor: 30.700

2.  Distribution and survival of Escherichia coli translocating from the intestine after thermal injury.

Authors:  J W Alexander; L Gianotti; T Pyles; M A Carey; G F Babcock
Journal:  Ann Surg       Date:  1991-06       Impact factor: 12.969

Review 3.  The potential role for xanthine oxidase inhibition in major intra-abdominal surgery.

Authors:  Anubhav Mittal; Anthony R J Phillips; Benjamin Loveday; John A Windsor
Journal:  World J Surg       Date:  2008-02       Impact factor: 3.352

4.  Hypertonic saline prevents early bacterial translocation in hemorrhagic shock.

Authors:  U Topaloğlu; A Yilmazcan; R Güloğlu; J Taşçioğlu; T Müftüoğlu; S Unalmişer
Journal:  Surg Today       Date:  1999       Impact factor: 2.549

5.  Enrichment of the lung microbiome with gut bacteria in sepsis and the acute respiratory distress syndrome.

Authors:  Robert P Dickson; Benjamin H Singer; Michael W Newstead; Nicole R Falkowski; John R Erb-Downward; Theodore J Standiford; Gary B Huffnagle
Journal:  Nat Microbiol       Date:  2016-07-18       Impact factor: 17.745

6.  Granulocyte macrophage colony-stimulating factor improves survival in two models of gut-derived sepsis by improving gut barrier function and modulating bacterial clearance.

Authors:  R Gennari; J W Alexander; L Gianotti; T Eaves-Pyles; S Hartmann
Journal:  Ann Surg       Date:  1994-07       Impact factor: 12.969

7.  The degree of bacterial translocation is a determinant factor for mortality after burn injury and is improved by prostaglandin analogs.

Authors:  R Fukushima; L Gianotti; J W Alexander; T Pyles
Journal:  Ann Surg       Date:  1992-10       Impact factor: 12.969

8.  Bioflora probiotic in immunomodulation and prophylaxis of intestinal bacterial translocation in rats.

Authors:  O M Laudanno; J A Cesolari; A Godoy; E Sutich; S Sarangone; J Catalano; P San Miguel
Journal:  Dig Dis Sci       Date:  2008-03-05       Impact factor: 3.199

9.  Arginine-supplemented diets improve survival in gut-derived sepsis and peritonitis by modulating bacterial clearance. The role of nitric oxide.

Authors:  L Gianotti; J W Alexander; T Pyles; R Fukushima
Journal:  Ann Surg       Date:  1993-06       Impact factor: 12.969

Review 10.  Preventively enteral application of immunoglobulin enriched colostrums milk can modulate postoperative inflammatory response.

Authors:  Klaus Orth; Wolfram Trudo Knoefel; Martijn van Griensven; Christiane Matuschek; Matthias Peiper; Holger Schrumpf; Peter Arne Gerber; Wilfried Budach; Edwin Bölke; Bettina Alexandra Buhren; Matthias Schauer
Journal:  Eur J Med Res       Date:  2013-11-23       Impact factor: 2.175
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.