Literature DB >> 27745950

Infants with low vaccine antibody responses have altered innate cytokine response.

Naveen Surendran1, Ted Nicolosi1, Michael Pichichero2.   

Abstract

We recently identified a population of 10% of infants who respond with sub-protective antibody levels to most routine primary pediatric vaccinations due to altered innate and adaptive immune responses. We term these infants as low vaccine responders (LVRs). Here we report new data showing that TLR7/8 agonist - R848 stimulation of PBMCs of LVR infants elicit significantly lower IFN-α, IL-12p70 and IL-1β, while inducing higher levels of CCL5 (RANTES) compared to normal vaccine responder (NVR) infants.
Copyright © 2016 Elsevier Ltd. All rights reserved.

Entities:  

Keywords:  IFN-α; IL12p70; IRF7; Infant innate immunity; Low vaccine response; RANTES

Mesh：

Substances：

Year:  2016        PMID： 27745950      PMCID： PMC5261827          DOI： 10.1016/j.vaccine.2016.09.050

Source DB:  PubMed          Journal:  Vaccine        ISSN： 0264-410X            Impact factor:   3.641


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