José María Moreno-Navarrete1, María Moreno1, Josep Puig2, Gerard Blasco2, Francisco Ortega1, Gemma Xifra1, Wifredo Ricart1, José Manuel Fernández-Real3. 1. Department of Diabetes, Endocrinology and Nutrition, Institut d'Investigació Biomèdica de Girona (IdIBGi), Hospital Dr Josep Trueta, CIBEROBN (CB06/03/010) and Instituto de Salud Carlos III (ISCIII), Girona, Spain. 2. Department of Radiology, Institut d'Investigació Biomèdica de Girona (IdIBGi), Hospital Dr Josep Trueta, Girona, Spain. 3. Department of Diabetes, Endocrinology and Nutrition, Institut d'Investigació Biomèdica de Girona (IdIBGi), Hospital Dr Josep Trueta, CIBEROBN (CB06/03/010) and Instituto de Salud Carlos III (ISCIII), Girona, Spain. Electronic address: jmfreal@idibgi.org.
Abstract
BACKGROUND & AIMS: Serum hepcidin concentration is known to increase in parallel to circulating markers of iron stores. We aimed to investigate whether this is reflected at the tissue level in subjects with obesity. METHODS: Serum hepcidin and ferritin levels (ELISA) and hepatic iron content (using magnetic resonance imaging) were analyzed longitudinally in 44 participants (19 without obesity and 25 with obesity). In a subgroup of 16 participants with obesity, a weight loss intervention was performed. RESULTS: Serum hepcidin, ferritin and hepatic iron content (HIC) were significantly increased in participants with obesity. Age- and gender-adjusted serum hepcidin was positively correlated with BMI, hsCRP, ferritin and HIC. In addition, age- and gender-adjusted serum hepcidin was positively correlated with ferritin and HIC in both non-obese and obese participants. In multivariate regression analysis, hepatic iron content (p < 0.01) and serum ferritin (p < 0.001) contributed independently to circulating hepcidin concentration variation after controlling for age, gender, BMI and hsCRP. Diet intervention-induced weight loss led to decreased serum hepcidin (p = 0.01), serum ferritin concentration (p = 0.01) and HIC (p = 0.002). Of note, the percent change of serum hepcidin strongly correlated with the percent change of serum ferritin (r = 0.69, p = 0.01) and HIC (r = 0.61, p = 0.03) even after controlling for age and gender. CONCLUSIONS: Serum hepcidin is a reliable marker of the hepatic iron content in subjects with obesity.
BACKGROUND & AIMS: Serum hepcidin concentration is known to increase in parallel to circulating markers of iron stores. We aimed to investigate whether this is reflected at the tissue level in subjects with obesity. METHODS: Serum hepcidin and ferritin levels (ELISA) and hepatic iron content (using magnetic resonance imaging) were analyzed longitudinally in 44 participants (19 without obesity and 25 with obesity). In a subgroup of 16 participants with obesity, a weight loss intervention was performed. RESULTS: Serum hepcidin, ferritin and hepatic iron content (HIC) were significantly increased in participants with obesity. Age- and gender-adjusted serum hepcidin was positively correlated with BMI, hsCRP, ferritin and HIC. In addition, age- and gender-adjusted serum hepcidin was positively correlated with ferritin and HIC in both non-obese and obeseparticipants. In multivariate regression analysis, hepatic iron content (p < 0.01) and serum ferritin (p < 0.001) contributed independently to circulating hepcidin concentration variation after controlling for age, gender, BMI and hsCRP. Diet intervention-induced weight loss led to decreased serum hepcidin (p = 0.01), serum ferritin concentration (p = 0.01) and HIC (p = 0.002). Of note, the percent change of serum hepcidin strongly correlated with the percent change of serum ferritin (r = 0.69, p = 0.01) and HIC (r = 0.61, p = 0.03) even after controlling for age and gender. CONCLUSIONS: Serum hepcidin is a reliable marker of the hepatic iron content in subjects with obesity.
Authors: Jordi Mayneris-Perxachs; José María Moreno-Navarrete; José Manuel Fernández-Real Journal: Nat Rev Endocrinol Date: 2022-08-19 Impact factor: 47.564
Authors: Benjamin J Ryan; Katherine L Foug; Rachel A Gioscia-Ryan; Pallavi Varshney; Alison C Ludzki; Cheehoon Ahn; Michael W Schleh; Jenna B Gillen; Thomas L Chenevert; Jeffrey F Horowitz Journal: Exp Physiol Date: 2021-02-17 Impact factor: 2.858
Authors: Aoibhín Moore Heslin; Aisling O'Donnell; Maria Buffini; Anne P Nugent; Janette Walton; Albert Flynn; Breige A McNulty Journal: Nutrients Date: 2021-05-02 Impact factor: 5.717
Authors: Teresa Auguet; Gemma Aragonès; Alba Berlanga; Salomé Martínez; Fàtima Sabench; Jessica Binetti; Carmen Aguilar; José Antonio Porras; Alicia Molina; Daniel Del Castillo; Cristóbal Richart Journal: PLoS One Date: 2017-10-24 Impact factor: 3.240
Authors: Joanna Gajewska; Jadwiga Ambroszkiewicz; Witold Klemarczyk; Ewa Głąb-Jabłońska; Halina Weker; Magdalena Chełchowska Journal: Int J Environ Res Public Health Date: 2018-10-01 Impact factor: 3.390