Mixed Methods Analysis of Sex Differences in Life Stressors of Middle-Aged Suicides.

INTRODUCTION: Between 1999 and 2013, rates of suicide in mid-life increased more than 30%. The purpose of this study is to examine life stressors impacting middle-aged suicide, to determine whether these stressors vary by sex, and to explore their co-occurrence.
METHODS: A random sample of 315 men and 315 women aged 35-64 years was selected from 17 states implementing the National Violent Death Reporting System from its inception in 2003 to 2011. Data collection took place between 2003 and 2011 and analysis occurred in 2015. Analysis included coding circumstances of death noted in the law enforcement and coroner/medical examiner reports using an investigator-designed coding instrument. Using the most commonly cited life stressors as a basis, thematic analyses were conducted for cases. Quantitative comparisons of the most common circumstances by sex were calculated via multivariable logistic regression.
RESULTS: The five most common life stressors of suicide included intimate partner, job/financial, health, family, and criminal/legal problems. In adjusted analyses, job/financial problems and criminal/legal problems were more common among men, whereas health and family problems were more common among women. Men and women had similar rates of intimate partner problems. Life stressors also co-occurred, as found per qualitative and quantitative analyses.
CONCLUSIONS: Men and women in mid-life have both common and unique circumstances preceding suicide. Prevention strategies that consider these circumstances and co-occurring circumstances are warranted. Published by Elsevier Inc.

Introduction

Maris[1] observed in 1987 that little is known about suicide in mid-life. In 1995, he warned that increases in suicide among baby boomers in their adolescence and early adulthood signaled subsequent suicide increases in mid-life.[2,3] Indeed, between 1999 and 2014, suicide among Americans aged 35–64 years increased 33.6%, from 13.7/100,000 to 18.3/100,000 (30.8% among men and 50.3% among women[4]), Theory suggests that mid-life typically involves intense investment in work and family and that perceived failed investments during this time may place socially isolated adults at risk for suicide.[5] Others identify theories of suicide related to gender roles and socialization (e.g., male masculinity).[6] These theories can provide a lens for differential distribution of specific premorbid circumstances impacting male and female suicide in mid-life, such as mental health/substance abuse problems (MH/SA-P), sociodemographic factors,[7] and life stressors, including relationship and physical health problems.[8-11] Understanding life stressors in particular is important because they are often modifiable, whereas many people with MH/SA-P do not seek out treatment[12] and sociodemographic factors are often immutable.

An understanding of life stressors can be guided by quantitative and qualitative information and analyses. Historically, psychological autopsy studies gathered information including suicide decedents’ psychological diagnoses and other life circumstances prior to suicide.[13] These studies tended to focus on youth,[14-16] older adults,[17-19] or specific subgroups (e.g., inpatients) without regard for, or while controlling for, age.[20-22] Qualitative analyses of mid-life suicide and the associated life stressors among men and women have been limited. Such analyses, beyond expensive psychological autopsy studies, may help to fill this gap.

As for quantitative analysis of mid-life suicide, it has only been since the recent recession and rising rates of suicide in this life stage that research on these suicides,[23] specifically, has increased.[7,24-28] Some of these studies have used the National Violent Death Reporting System (NVDRS) quantitative data elements, which are useful for examining broad trends. However, none except for one[8] has used NVDRS qualitative narratives, which provide more specific information about premorbid life stressors, in men and women. To this end, the current study qualitatively examines contextual and specific life stressors and quantitatively examines the association between these stressors in men and women in the presence of other circumstances.

Methods

Data for this study come from NVDRS, a surveillance system operating in 32 U.S. states. NVDRS includes decedent characteristics, manner, cause, and circumstances of death. Information is abstracted from law enforcement and coroner/medical examiner investigative reports (called “narratives” hereafter), toxicology reports, and death certificates. NVDRS and its methodology are described elsewhere.[29,30]

Data Sample

A sample of 630 suicide decedents (315 women, 315 men), aged 35–64 years, was randomly selected and represented 1.5% of all mid-aged suicides with any circumstances in the 17 NVDRS states contributing data between 2003 and 2011 (N=41,917 [10,493 women, 31,424 men]). The analytic sample represents the NVDRS population, except for location; the sample included more people from the West and fewer from the Midwest, though there is no anticipated bias apart from means of suicide, which is not a focus here. The sample size was deemed sufficient to conduct adjusted quantitative analyses and small enough to conduct thorough qualitative analyses. Suicides without any known circumstances were excluded from the sampling frame (n=4,558 or 9.8%).

Statistical Analysis

Data analysis occurred in three phases described elsewhere in depth.[8] In brief, they included:

coding broad and more specific categories of life stressors (e.g., broad, job problems; specific, unemployment), other circumstances (e.g., MH/SA-P), and temporality of suicide circumstances (e.g., recent, chronic) using a research team–developed coding guide;

exploring patterns of co-occurring circumstances within commonly occurring life stressors; and

conducting quantitative analyses.

Chi-square statistics and ANOVA were used to examine male–female differences in individual (e.g., age) and incident characteristics (e.g., means of suicide), year (2003–2006 [pre-recession], 2007–2009 [recession], and 2010–2011 [post-recession]), and geographic location of suicides (Northwest, Northeast, West, Midwest, and South). Next, bivariate analyses tested male female differences in common life stressors and MH/SA-P. Finally, multivariable logistic regression analyses assessed the AORs and 95% CIs of the commonly occurring life stressors for men versus women, controlling for a priori individual characteristics, year, place, and all other common life stressors. Quantitative analyses were conducted in 2015 using SAS, version 9.3, with α=0.05.

Results

On average, decedents were aged 48.6 years, and most (88.1%) were non-Hispanic white (Tables 1, 2). More than one third of decedents left a suicide note and approximately 25% disclosed suicidal intent. Two thirds of suicides took place in the South or West, and the pro-portion of suicides was roughly equal across time periods. More men died by firearms (chi-square [1]=32.4, p<0.001) and hanging (chi-square [1]=4.8, p<0.05), whereas more women died by poisoning (chi-square [1]=64.2, p<0.001).

Table 1.

Demographic Characteristics and Circumstances of Suicide, Aged 35–64 Years, by Sex, 17 NVDRS States, 2003–2011

Individual characteristics	Males (n=315)	Females (n=315)	Total	F/χ2
Mean age, years	48.9	48.3	48.6	F=1.09
Race, %
Non-Hispanic white	87.6	88.6	88.1	0.14
Other race/ethnicity	12.4	11.4	11.9
Left suicide note, %	32.4	39.1	35.7	3.05
Disclosed intent, %	20.3	27.9	24.1	3.50[*]
Means of suicide				66.2***[a]
Firearms	55.9	33.3	44.6	32.4***[b]
Hanging	21.3	14.6	17.9	4.8[*b]
Poisoning	16.2	45.7	31.0	64.2***[b]
Other	6.70	6.40	6.50	0.03
Place characteristics, %				5.7
Northwest (AK, OR)	9.5	7.6	8.6
Northeast (MA, NJ, RI)	17.8	16.5	17.1
West (CO, NM, OK, UT)	25.4	27.6	26.5
South (GA, MD, NC, SC, VA)	41.9	38.4	40.2
Midwest (KY, OH, WI)	5.4	9.8	7.6
Time characteristics, %				2.0
Pre-recession (2003–2006)	34.6	29.5	32.1
Great recession (2007–2009)	36.2	40.0	38.1
Post-recession (2010–2011)	29.2	30.5	29.8
Circumstances/life stressors, %
Intimate partner problems	35.2	32.7	34.0	0.45
Job/financial problems	37.1	21.6	29.4	18.4***
Any job problems	24.8	11.4	18.1	18.9***
Any financial problems	21.9	15.9	18.9	3.7[**]
Physical health problems	22.5	33.9	28.3	10.1[**]
Family problems	13.3	23.2	18.3	10.22[**]
Criminal/legal problems	19.4	11.8	15.6	7.0[**]
MH/SA problems	67.9	82.2	75.1	17.2***
Treatment for MH/SA	25.4	44.4	34.9	25.1***
Prior suicidal ideation/behavior	36.8	60.0	48.4	33.9***

Note: Boldface indicates statistical significance

p

p<0.01

p<0.001

Significant difference overall in means of suicide used between males and females.

Significant difference in specific means used between males and females.

MH/SA, mental health and/or substance abuse problem; NVDRS, National Violent Death Reporting System.

Table 2.

Narrative Examples of Suicides, Aged 35–64 Years, in 17 NVDRS States, by Sex and Circumstances, 2003–2011

		Narrative examples with life stressor codes
Life stressorspreceding suicide	Subcategories oflife stressors	Males	Females
Intimate partnerproblem(RELATIONSHIP-P)	Argument/fightingLeft home/separationDivorce/break-upInfidelityViolence perpetrationViolence victimizationOtherRELATIONSHIP-P	V was under indictment for sexual assault on achild (LEGAL-P; sex misconduct-ongoing). Perfriend, V was having trouble finding an attorney,as he did not qualify for public defender and didnot have funds to hire an outside attorney (JOB/FINAN; financial-ongoing). V had history ofmultiple suicide attempts (Hx suicide attempts)and was diagnosed with depression (MH/SA). Vwas raised with a large number of siblings withvery strict parents who abused them (FAMILY-P;ACE). V’s older brother killed himself (FAMILY-P;Hx suicide)	Decedent was the victim of IPV (RELATIONSHIPP; IPV) resulting in a rib fracture; she was beingtreated for PTSD and depression (MH/SA) andoften abused alcohol and methamphetamines(MH/SA; alcohol, drug use) She also recentlylearned that her daughter was diagnosed withcancer (FAMILY-P; other-recent). Further, shehad attempted suicide at least three timeswithin 2 years of her death (Hx suicideattempts).
Job/financial problem(JOB/FINAN)	Co-worker problemsUnemployedLost jobOther job problemsLost homeIn debt/can’t pay billsOther JOB/FINAN-P	V was found deceased in his driveway as theresult of a single self-inflicted gunshot wound. Vwas estranged from his wife (RELATIONSHIP-P;break-up-chronic), had been fired from his job(job problem-ongoing) and was unable to workdue to physical health issues, (HEALTH-P;unspecified-chronic) and the V suffered from analcohol problem (MH/SA; alcohol abuse-chronic). In the V’s residence police found anotice for the cut off of his electrical service fornon-payment of the bill (the power was alreadycut off) (JOB/FINAN-P; financial). A (suicide note)was located in the V’s pocket.	V was found dead in her house by her adultdaughter. Daughter was concerned about Vbecause she had been depressed lately (MH/SA; recent) and drinking every day (MH/SA;alcohol). She was having trouble finding a job(JOB/FINAN-P; unemployed, ongoing), and shewas in the process of losing her house (JOB/FINAN-P; Financial-loss of house, recent). V wasrecently divorced (RELATIONSHIP-P; divorce,recent). Several (suicide notes) were found inthe house.
Physical healthproblem (HEALTH-P)	CancerChronic diseasePainOther healthproblems	V believed he had pancreatic cancer (HEALTH-P;cancer) due to some symptoms he wasexperiencing. The symptoms had existed for ayear or more (chronic) and V believed his insideswere rotting out. In the past, V underwentsurgery for a ruptured colon (HEALTH-P; other-surgery).	V suffered from fibromyalgia (HEALTH-P;chronic) and was in a great deal of [pain]. V hadbeen unable to work for over (JOB/FINAN-P; job-chronic) a year due to the pain. V had neverattempted suicide but often joked aboutoverdosing (Hx ideation) and her fear she wouldbe found then her stomach pumped.
Family problem(FAMILY-P)	Death of friend/family memberFamily history ofincarcerationFamily history of MHproblemsChild maltreatment bydecedentACEOther family problems	V found dead at his home. V’s medical historyincluded a severe accident that left him mildlymentally and physically disabled (HEALTH-P;other/ accident/ disability-chronic). Since thatevent V had bouts of depression (MH/SA) with(suicidal ideation) and (attempts) via drugoverdose. The prior day, V got upset with one ofthe children (FAMILY-P; argument-recent) andstarted yelling and hitting objects. Police werecalled to the scene but no arrests were made(LEGAL-P). V’s mother died within past 2 weeks(FAMILY-P; death-recent).	V’s daughter states that she and the V had afight (FAMILY-P; argument-recent) and she wassupposed to move back home the day after theincident (JOB/FINAN-P; housing). When thedaughter got up on incident date, she had a textfrom the V threatening to kill herself (disclosedsuicide). The daughter stated that her motherhad done this many times (Hx ideation). She toldher mother she was “stupid and ridiculous.”
Criminal/legalproblems (LEGAL-P)	Child and familyservices referralSexual misconductDrug/alcohol-related chargeArrest/warrantfor arrestRecent/pendingincarcerationOther LEGAL-P, e.g.,restraining orderHomicideAttempted homicide	V shot himself with a revolver after the policepursued him. V had a protective order againsthim (LEGAL-P; protective order) and, with asledgehammer, hit the windshield of the vehicleowned by the woman who had the protectiveorder put on him (RELATIONSHIP-P; recentintimate partner violence). V had been releasedfrom jail days earlier (recent incarceration). Vhad been arrested for assault with a dangerousweapon, violation of a protective order andresisting an officer (recent arrest for variousLEGAL-Ps).	V died at her residence as a result of anoverdose of prescription drugs as well as theillicit drug methamphetamine (drug useimmediately prior to death). V had diagnosedanxiety (MH/SA) and was taking psychiatricmedications (in treatment for mental healthproblem). This day, V was arrested for drivingunder the influence (LEGAL-P_recent arrest,alcohol-related charge). V had threatenedsuicide (suicidal ideation) to her boyfriendstating that she would take a bunch ofprescription medication to kill herself if facedwith jail time.

Note: Narrative details have been modified to reduce risk of victim identification.

ACE, adverse childhood experience; Hx, history; IPV, intimate partner victimization; MH, mental health; NVDRS, National Violent Death Reporting System; PTSD, post-traumatic stress disorder; SA, substance abuse; V, victim.

The most prevalent life stressors included intimate partner problems (RELATIONSHIP-P, 34%), job/financial problems (JOB/FINAN-P, 29.4%), physical health problems (HEALTH-P, 28.3%), family problems (FAMILY-P, 18.3%), and criminal/legal problems (LEGAL-P, 15.6%) (Table 1). In bivariate analyses, men experienced more JOB/FINAN-P and LEGAL-P than women (p<0.01). Women experienced more HEALTH-P and FAMILY-P than men (p<0.01). No sex difference was observed for RELATIONSHIP-P. Three quarters of decedents reported MH/SA-P. Prevalence among women was greater than men (p<0.001). About 35% of suicides had any MH/SA treatment noted (44.4% among women vs 25.4% among men, p<0.001). Finally, 48.4% of decedents had known prior suicide ideation/attempts (60% women vs 36.8% men, p<0.001).

About one third of decedents experienced RELATIONSHIP-P (Figure 1). Twenty-seven percent (n=28) of women and 36.9% of men (n=41) experienced multiple RELATIONSHIP-P. For example, “V’s (victim’s) boyfriend was incarcerated for assaulting her [code: intimate partner victimization]. When released, he discovered that she had cheated on him [infidelity]. They argued frequently [chronic arguing] about this.” RELATIONSHIP-P commonly referenced relationship break-ups and recent arguments. JOB/FINAN-P were referenced frequently as the topic of arguments between partners; for example, “V’s wife said they argued about V’s lack of keeping a job.” Infidelity accusations were also notable for men who perpetrated homicide—suicide. LEGAL-P were noted more among men with RELATIONSHIP-P while co-occurrence of FAMILY-P and HEALTH-P were noted more among women. Men and women commonly experienced MH-P, but women appeared to have more SA-P than men. Women also appeared to receive MH/SA treatment, have a history of suicide ideation/attempts, and disclosed suicide intent more than men. Treatment was more frequently described among decedents with known MH/SA-P, prior suicidal ideation/attempts, and who disclosed suicidal intent. However, most people were not known to have received treatment.

Figure 1.

Co-occurring problems in a sample of male (n=315) and female (n=315) suicide decedents, aged 35–64 years, with RELATIONSHIP-P, JOB/FINAN-P, LEGAL-P, FAMILY-P, and HEALTH-P in 17 NVDRS states.

aReflects percentage of males who perceived an infidelity among those who committed homicide-suicide.

bAmong people with financial problems.

cAmong people with pain conditions.

dReflects percentage of “other” category.

Any Suic Hx, any history of suicidal ideation or attempts; Attempted hom, Attempted homicide; C pain, chronic pain; Chronic, chronic disease; Disclosed, disclosed suicide intent; Family hx suic, family history of suicide; HEALTH-P, physical health problems; JOB/FINAN-P, job/Financial problems; LEGAL-P, criminal/legal problems; MH/SA-P, mental health/substance abuse problems; NVDRS, National Violent Death Reporting System; RELATIONSHIP-P, intimate partner problem.

Sixty-eight women and 117 men experienced JOB/FINAN-P (overall, 29.4%) (Figure 1). Most experienced a job or financial problem, not both. Among women, financial problems appeared more common than job problems and mentions of chronic debt arose frequently; for example, “V had a negative bank account balance, was going into collections, and unable to pay her bills.” Conversely, men appeared to experience more job than financial problems. For both sexes, unemployment was noted frequently. Both recent (“The victim recently lost his job due to an injury”) and chronic unemployment (“Sister stated that V was unemployed for approximately 5 years …”) were common among men, whereas unemployment appeared more chronic in nature for women, often co-occurring with HEALTH-P or MH/SA-P (“V suffered from depression since her son’s suicide 10 years earlier … V lost her job a year prior”). Among men and women, housing issues were fairly common (“V was being evicted from his apartment”). About one quarter of people with JOB/FINAN-P had co-occurring FAMILY-P cited. LEGAL-P and RELATIONSHIP-P were reported similarly among men and women. Women more frequently than men disclosed their suicidal intent, received any MH/SA treatment, and had prior suicidal behavior.

Thirty-four percent (n=107) of women and 22.5% (n=71) of men experienced known HEALTH-P (Figure 1). Of these, 43.9% of women and 26.8% of men had more than one HEALTH-P: “V was non-compliant with monitoring his blood pressure. He also has a long history of pancreatitis and severe abdominal pain [chronic HEALTH-P].” Chronic disease appeared more frequent among men and restricted decedents’ activities, for example, “chronic health problems … had taken away his independence.” Conversely, more women than men seemed to experience pain, and when pain was mentioned it tended to more chronic in nature: “Victim mentioned suicide on many occasions as an ‘out’ to her chronic unbearable pain.” Although cancer was not frequently noted, it appeared to impact many aspects of decedents’ lives: “The V had to quit his job and undergo intensive radiation treatment.” Other HEALTH-P were common and included recent or acute-on-chronic (i.e., recent exacerbation of a chronic problem), hospitalizations, injuries, surgery, and unspecified issues. Most people with HEALTH-P had MH/SA-P, with more women than men receiving treatment. RELATIONSHIP-P and JOB/FINAN-P were noted in about 25% and 28% of cases, respectively. Women more commonly than men experienced FAMILY-P, whereas LEGAL-P appeared to arise more among men. Unlike other areas, men with HEALTH-P disclosed suicide intent more frequently than women. More women than men had a history of ideation and attempts.

Eighteen percent of decedents (23.2% women, 13.3% men) had FAMILY-P (Figure 1), with 24.6% of women and 69% of men experiencing multiple FAMILY-P. Problems often involved death of a loved one, with many deaths having occurred within the previous month or year. Men more than women experienced a family history of suicide: “… V’s son committed suicide 5 years ago. Since then V had become more depressed.” Most decedents had other FAMILY-P noted. Many involved arguments that occurred the day of, or the day prior to, suicide. Most arguments involved the decedent and their child, parents, siblings, or other relatives. Arguments related to the decedent’s drinking, medication abuse, or MH/SA-P, financial and property disagreements, and health problems of a family member (e.g., “Victim was the caregiver for her father and had taken little vacation in the past 10 years”). Mentioned less frequently were death of pets and recent moves of family members. Most people with FAMILY-P appeared to have MH/SA-P and many cases noted co-occurring RELATIONSHIP-P and HEALTH-P; this was approximately equal among men and women. However, more men than women seemed to experience co-occurring JOB/FINAN-P and LEGAL-P. About one third of women had known MH/SA treatment, yet 57.5% had a history of suicide ideation or attempts. More than 50% of women disclosed intent prior to suicide.

Sixty-one men (19.4%) and 37 women (11.7%) experienced LEGAL-P (Figure 1). Most LEGAL-P among men involved homicide or attempted homicide, often within hours of death. Two women perpetrated homicide (none attempted). Most homicides involved the decedent’s partner or ex-partner. Of the 37 women who had LEGAL-P, most were unspecified and appeared chronic or acute-on-chronic in nature. Other commonly occurring LEGAL-P included a recent release from, or fear of pending, incarceration and sexual misconduct among men. Men and women who perpetrated homicide often had other co-occurring problems, such as RELATIONSHIP-P. For instance, one man who killed his partner had “a history of domestic problems…. A protective order was filed a few months ago against him.” Women with LEGAL-P appeared to experience SA-P: “Mother reported that V was recently arrested for driving under the influence and attempted suicide while in the holding cell.” It appeared that many more women than men with LEGAL-P had an MH/SA-P, received MH/SA treatment, disclosed suicide intent, and had a history of suicide ideation/attempts.

Logistic regression analyses found the same pattern of sex differences found in bivariate analyses: Men had significantly greater odds than women of JOB/FINAN-P and LEGAL-P (Table 3, Models B and E), and women had significantly greater odds than men of HEALTH-P and FAMILY-P (Models C and D), controlling for all other factors. There were no significant differences between men and women in odds of RELATIONSHIP-P (Model A). RELATIONSHIP-P and LEGAL-P were significantly negatively associated with HEALTH-P (Model C), and were positively associated with each other (Models A and E). That is, people with LEGAL-P had 69% greater odds of RELATIONSHIP-P than people without LEGAL-P (Model A) and, likewise, people with RELATIONSHIP-P had 65% greater odds of LEGAL-P compared with those without RELATIONSHIP-P (Model E). People with MH/SA-P had more than twice the odds of FAMILY-P as compared with those without MH/SA-P (Model D), and known MH/SA-P were negatively associated with LEGAL-P (AOR=0.49, 95% CI=0.30, 0.82, p<0.01, Model E). People with any mental health treatment had significantly reduced odds of RELATIONSHIP-P (Model A; AOR=0.62, 95% CI=0.41, 0.93) and prior suicidal ideation/attempts was not associated with any of the examined life stressors, controlling for all other variables. The years pre- and post-recession (versus recession years) were not associated with significantly decreased odds of any life stressors (Table 3), except for LEGAL-P, for which a 49% reduction in odds was observed after the recession. Additionally, RELATIONSHIP-P were elevated pre- and post-recession compared with during the recession. Post-hoc interactions between year and sex were tested. No significant effect was found (results not shown).

Table 3.

Odds of Specific Life Stressors Preceding Suicide, Among a Sample of Males and Females Aged 35–64 Years, in 17 NVDRS States (n=630)

Variable	Intimate partnerproblem (Model A)	Job/financialproblem (Model B)	Physical healthproblem(Model C)	Family problem(Model D)	Criminal/legalproblem(Model E)
Male(ref=female)	1.01 (0.69, 1.49)	2.41 (1.64, 3.54)[***]	0.56 (0.38, 0.84)[**]	0.54 (0.34, 0.86)[**]	1.71 (1.04, 2.80)[*]
Age	0.95 (0.93, 0.97)[***]	1.01 (0.98, 1.03)	1.04 (1.02,1.07)[**]	0.97 (0.95, 1.00)	0.99 (0.96, 1.02)
Racial/ethnicminority(ref=white/NH)	0.87 (0.51, 1.49)	1.01 (0.57, 1.76)	1.26 (0.67, 2.39)	0.86 (0.45, 1.64)	1.21 (0.61, 2.43)
RELATIONSHIP-P	—	1.14 (0.77, 1.68)	0.54 (0.35, 0.83)[**]	1.26 (0.80, 1.99)	1.65 (1.03, 2.66)[*]
JOB/FINAN-P	1.13 (0.76, 1.67)	—	0.99 (0.66, 1.50)	1.48 (0.93, 2.36)	0.78 (0.47, 1.30)
HEALTH-P	0.54 (0.35, 0.82)[**]	0.96 (0.63, 1.45)	—	1.04 (0.65, 1.68)	0.54 (0.30, 0.97)[*]
FAMILY-P	1.28 (0.81, 2.02)	1.48 (0.94, 2.35)	1.06 (0.66, 1.71)	—	0.97 (0.53, 1.78)
LEGAL-P	1.69 (1.06, 2.71)[*]	0.78 (0.47, 1.31)	0.54 (0.30, 0.97)[*]	0.95 (0.52, 1.74)	—
MH/SA-P	1.33 (0.86, 2.05)	1.41 (0.91, 2.19)	1.15 (0.72, 1.84)	2.30 (1.24, 4.29)[**]	0.49 (0.30, 0.82)[*]
MH/SA treatment	0.62 (0.41, 0.93)[*]	0.74 (0.49, 1.12)	0.96 (0.64, 1.44)	1.39 (0.88, 2.20)	1.08 (0.64, 1.82)
Prior ideation/attempt	1.08 (0.74, 1.58)	1.13 (0.77, 1.65)	0.94 (0.63, 1.39)	0.93 (0.59, 1.46)	1.22 (0.75, 1.99)
2003–2007(ref=2008–2009)	1.73 (1.09, 2.73)	0.71 (0.46, 1.10)	0.98 (0.62, 1.54)	0.94 (0.56, 1.57)	0.90 (0.53, 1.55)
2010–2011	1.75 (1.07, 2.87)	0.98 (0.61, 1.56)	0.77 (0.46, 1.28)	0.70 (0.39, 1.26)	0.51 (0.27, 0.97)[*]

Note: Boldface indicates statistical significance

p<0.05

p<0.01

p<0.001

Data are OR (95% CI). All models adjusted for geographic location. All variables categorical except age, which is continuous.

FAMILY-P, family problem; HEALTH-P, physical health problem; JOB/FINAN-P, job/financial problem; LEGAL-P, legal problem; MH/SA-P, mental health and/or substance abuse problem; NH, non-Hispanic; NVDRS, National Violent Death Reporting System; RELATIONSHIP-P, intimate partner problem.

Discussion

Results suggest that middle-aged men and women have both common and unique life stressors preceding suicide, and these circumstances frequently co-occur. Qualitative analyses indicate that specific types of problems are more commonly experienced by subgroups of decedents. For example, infidelity is a specific type of RELATIONSHIP-P, more common among homicide–suicides than single-victim suicides. Additionally, qualitative analyses indicate that precipitating problems tend to “pile up,” or accumulate. For example, women with JOB/FINAN-P tended to experience chronic unemployment, frequently because of HEALTH-P, such as chronic pain, and FAMILY-P tended to occur more among people with MH/SA-P and co-occurring RELATIONSHIP-P and HEALTH-P.

Quantitative analyses reinforced qualitative results and indicated that women were more likely to have known HEALTH-P and FAMILY-P, whereas men were more likely to have JOB/FINAN-P and LEGAL-P. Both had similar odds of RELATIONSHIP-P, the most commonly noted life stressor. Certain circumstances were also more or less associated with each other (e.g., RELATIONSHIP-P and LEGAL-P were positively associated to each other and negatively associated with HEALTH-P). In the context of multivariable models, MH/SA-P were positively associated with FAMILY-P and negatively associated with LEGAL-P, likely reflecting the larger and smaller proportion of women in these categories, respectively, and the greater likelihood of MH/SA diagnosis in women. People with MH/SA treatment were less likely to experience RELATIONSHIP-P, which provides useful prevention information.

The broad life stressors identified using mixed methods in this study concur with prior psychological autopsy studies[26,31-34] and indicate similar sex differences.[5,26,31,34] For example, middle-aged male suicides in the United Kingdom more often had JOB/FINAN-P compared with women, whereas women more often had FAMILY-P. Relationship breakdown (RELATIONSHIP-P) was similarly common in middle-aged male and female suicides.[5] Conversely, other researchers using NVDRS reported lower estimates for all life stressors in men and women among decedents aged 40–64 years.[26] This may be attributed to examination of different years of data (2005–2010 vs 2003–2011), a census of suicides in 17 states versus a random sample, or the additional information provided by qualitative case narratives versus quantitative data alone. In an earlier study, researchers examined circumstances 1 week and 3 months preceding all Finnish suicides.[31] Estimates of JOB/FINAN-P, HEALTH-P, and FAMILY-P were similar in magnitude to those in the current study; however, estimates of RELATIONSHIP-P were about half as much. This pattern of results was also true of 100 suicides in the United Kingdom,[5] and is likely due to the broad RELATIONSHIP-P issues able to be extracted from the NVDRS narratives in the current study.

The current study has several strengths. Its mixed methods approach using abstracted death scene narratives provides a novel way of considering co-occurring circumstances and their complex interplay among men and women. Qualitative analyses allowed for examination of specific types of broad problems (e.g., chronic pain as a health problem among women) and the temporality of specific problems. Although NVDRS quantitative data contain a variable indicating whether decedents experienced a recent crisis, this variable does not indicate which of the multiple problems the decedent experienced was considered the recent crisis. Addition-ally, the study focuses on middle-aged adults, specifically, a population with growing suicide mortality and the study examined important sex differences. The sample size was both considerably large for a qualitative analysis and sufficient to detect significant differences by sex in adjusted quantitative analyses.

Limitations

Limitations include the collection of circumstance data from proxies. However, this weakness is common to all postmortem methodologies.[13] Other NVDRS limitations pertain to this study as well. Results may not generalize to the entire U.S. population, given they come from just 17 states,[35] and the sample was not representative of all regions. Also, year of death was tested in unequal time categories. However, this was purposeful to reflect the recession and pre- and post-recession years. Finally, the current study did not employ a control group. However, the primary purpose was to compare men and women who died by suicide. Further in-depth study assessing clustering of co-occurring circumstances and sex differences in suicide is warranted.

Conclusions

Study findings have implications for prevention. For example, professionals who work with middle-aged adults (e.g., criminal–legal, medical, human resources) may benefit from assessing co-occurring problems in individuals’ lives and training on recognizing and responding to warning signs of suicide. Referral into MH/SA treatment may help decrease the likelihood of future crisis situations and life stressors, such as RELATIONSHIP-P. Decreasing stigma related to seeking help, particularly among men, is critical, given their low treatment rates.[36] Other important prevention strategies include increased mental health literacy, especially given the large proportion of decedents with prior suicidal behavior or who disclosed suicidal intent. Additionally, upstream strategies—those seeking to prevent suicide risk from arising in the first place[37]—can focus on improved problem solving and enhanced coping skills among younger generations to manage negative life events. Efforts to enhance social connectedness may buffer stressors related to interpersonal difficulties.[5] Connectedness can also decrease one’s sense of burden-someness,[38] sometimes observed among those with HEALTH-P and other chronic issues.[39] Comprehensive strategies for suicide prevention have been found to be effective in reducing suicide in work places such as the U.S. Air Force and among first responders.[40,41] Suicide is preventable and a greater understanding of the circumstances behind middle-aged suicide, for men and women, can help reverse troubling recent trends.