Literature DB >> 2774504

Altered glucose metabolism in microvessels from patients with Alzheimer's disease.

D L Marcus1, M J de Leon, J Goldman, J Logan, D R Christman, A P Wolf, J S Fowler, K Hunter, J Tsai, J Pearson.   

Abstract

Microvessels isolated from temporal cortex of patients with Alzheimer's disease showed decreased uptake of glucose when compared with vessels from age-matched or young control subjects. This was due to decreased hexokinase activity in the Alzheimer samples, as determined by ion exchange chromatography. This finding was confirmed independently by determination of the phosphorylation constant for hexokinase, K3, using positron emission tomography. The results suggest that Alzheimer's disease may result from a global defect in brain energy metabolism.

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Year:  1989        PMID： 2774504     DOI： 10.1002/ana.410260114

Source DB:  PubMed          Journal:  Ann Neurol        ISSN： 0364-5134            Impact factor:   10.422


  10 in total

1.  Analysis of aluminum-yeast hexokinase interaction: modifications on protein structure and functionality.

Authors:  J M Socorro; R Olmo; C Teijón; M D Blanco; J M Teijón
Journal:  J Protein Chem       Date:  2000-04

Review 2.  Brain fuel metabolism, aging, and Alzheimer's disease.

Authors:  Stephen Cunnane; Scott Nugent; Maggie Roy; Alexandre Courchesne-Loyer; Etienne Croteau; Sébastien Tremblay; Alex Castellano; Fabien Pifferi; Christian Bocti; Nancy Paquet; Hadi Begdouri; M'hamed Bentourkia; Eric Turcotte; Michèle Allard; Pascale Barberger-Gateau; Tamas Fulop; Stanley I Rapoport
Journal:  Nutrition       Date:  2010-10-29       Impact factor: 4.008

3.  Age-related defects in erythrocyte 2,3-diphosphoglycerate metabolism in dementia.

Authors:  Yury G Kaminsky; V Prakash Reddy; Ghulam Md Ashraf; Ausaf Ahmad; Valery V Benberin; Elena A Kosenko; Gjumrakch Aliev
Journal:  Aging Dis       Date:  2013-10-01       Impact factor: 6.745

4.  Dichlorvos induced alterations in glucose homeostasis: possible implications on the state of neuronal function in rats.

Authors:  S Sarin; K D Gill
Journal:  Mol Cell Biochem       Date:  1999-09       Impact factor: 3.396

5.  Upregulation of ribosome complexes at the blood-brain barrier in Alzheimer's disease patients.

Authors:  Masayoshi Suzuki; Kenta Tezuka; Takumi Handa; Risa Sato; Hina Takeuchi; Masaki Takao; Mitsutoshi Tano; Yasuo Uchida
Journal:  J Cereb Blood Flow Metab       Date:  2022-06-29       Impact factor: 6.960

Review 6.  Brain glucose metabolism in the early and specific diagnosis of Alzheimer's disease. FDG-PET studies in MCI and AD.

Authors:  Lisa Mosconi
Journal:  Eur J Nucl Med Mol Imaging       Date:  2005-04       Impact factor: 9.236

Review 7.  Mechanism of Alzheimer's disease: arguments for a neurotransmitter-aluminium complex implication.

Authors:  R Deloncle; O Guillard
Journal:  Neurochem Res       Date:  1990-12       Impact factor: 3.996

Review 8.  The pericyte: a forgotten cell type with important implications for Alzheimer's disease?

Authors:  Ethan A Winkler; Abhay P Sagare; Berislav V Zlokovic
Journal:  Brain Pathol       Date:  2014-07       Impact factor: 6.508

Review 9.  Metabolic Abnormalities of Erythrocytes as a Risk Factor for Alzheimer's Disease.

Authors:  Elena A Kosenko; Lyudmila A Tikhonova; Carmina Montoliu; George E Barreto; Gjumrakch Aliev; Yury G Kaminsky
Journal:  Front Neurosci       Date:  2018-01-05       Impact factor: 4.677

Review 10.  Iron and aluminum homeostasis in neural disorders.

Authors:  J G Joshi; M Dhar; M Clauberg; V Chauthaiwale
Journal:  Environ Health Perspect       Date:  1994-09       Impact factor: 9.031
  10 in total

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