Literature DB >> 27744641

Somatosensory regulation of serotonin release in the central nucleus of the amygdala is mediated via corticotropin releasing factor and gamma-aminobutyric acid in the dorsal raphe nucleus.

Ryota Tokunaga1, Rie Shimoju2, Hideshi Shibata3, Mieko Kurosawa4,5,6.   

Abstract

Noxious cutaneous stimulation increases, whereas innocuous cutaneous stimulation decreases serotonin (5-HT) release in the central nucleus of the amygdala (CeA) in anesthetized rats. In the present study, we investigated the contribution of corticotropin releasing factor (CRF) receptors and gamma-aminobutyric acid (GABA) receptors in the dorsal raphe nucleus (DRN) to those responses. Release of 5-HT in the CeA was monitored by microdialysis before and after 10-min stimulation by pinching or stroking. Increased 5-HT release in the CeA in response to pinching was abolished by CRF2 receptor antagonism in the DRN. Decreased 5-HT release in the CeA in response to stroking was abolished by either CRF1 receptor antagonism or GABAA receptor antagonism in the DRN. These results suggest that opposite responses of 5-HT release in the CeA to noxious versus innocuous stimulation of the skin are due to separate contributions of CRF2, CRF1 and GABAA receptors in the DRN.

Entities:  

Keywords:  CRF1 receptor; CRF2 receptor; GABAA receptor; Microdialysis; Pinching; Stroking

Mesh：

Substances：

Year:  2016        PMID： 27744641     DOI： 10.1007/s12576-016-0498-4

Source DB:  PubMed          Journal:  J Physiol Sci        ISSN： 1880-6546            Impact factor:   2.781


  35 in total

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Journal:  Horm Behav       Date:  2005-03-17       Impact factor: 3.587

2.  Effects of corticotropin-releasing factor on brain serotonergic activity.

Authors:  M L Price; A L Curtis; L G Kirby; R J Valentino; I Lucki
Journal:  Neuropsychopharmacology       Date:  1998-06       Impact factor: 7.853

3.  Corticotropin-releasing factor-containing afferents to the inferior colliculus of the rat brain.

Authors:  M Sakanaka; T Shibasaki; K Lederis
Journal:  Brain Res       Date:  1987-06-23       Impact factor: 3.252

4.  Pain-related fear is more disabling than pain itself: evidence on the role of pain-related fear in chronic back pain disability.

Authors:  G Crombez; J W Vlaeyen; P H Heuts; R Lysens
Journal:  Pain       Date:  1999-03       Impact factor: 6.961

5.  Cloning and characterization of a functionally distinct corticotropin-releasing factor receptor subtype from rat brain.

Authors:  T W Lovenberg; C W Liaw; D E Grigoriadis; W Clevenger; D T Chalmers; E B De Souza; T Oltersdorf
Journal:  Proc Natl Acad Sci U S A       Date:  1995-01-31       Impact factor: 11.205

6.  Distribution of mRNAs encoding CRF receptors in brain and pituitary of rat and mouse.

Authors:  K Van Pett; V Viau; J C Bittencourt; R K Chan; H Y Li; C Arias; G S Prins; M Perrin; W Vale; P E Sawchenko
Journal:  J Comp Neurol       Date:  2000-12-11       Impact factor: 3.215

7.  Time-dependent induction of anxiogenic-like effects after central infusion of urocortin or corticotropin-releasing factor in the rat.

Authors:  M G Spina; E Merlo-Pich; Y Akwa; C Balducci; A M Basso; E P Zorrilla; K T Britton; J Rivier; W W Vale; G F Koob
Journal:  Psychopharmacology (Berl)       Date:  2001-12-20       Impact factor: 4.530

8.  Restraint stress increases serotonin release in the central nucleus of the amygdala via activation of corticotropin-releasing factor receptors.

Authors:  Bing Mo; Na Feng; Kenneth Renner; Gina Forster
Journal:  Brain Res Bull       Date:  2008-03-04       Impact factor: 4.077

9.  Microinjection of urocortin 2 into the dorsal raphe nucleus activates serotonergic neurons and increases extracellular serotonin in the basolateral amygdala.

Authors:  J Amat; J P Tamblyn; E D Paul; S T Bland; P Amat; A C Foster; L R Watkins; S F Maier
Journal:  Neuroscience       Date:  2004       Impact factor: 3.590

Review 10.  Corticotropin-releasing factor-related peptides, serotonergic systems, and emotional behavior.

Authors:  James H Fox; Christopher A Lowry
Journal:  Front Neurosci       Date:  2013-09-20       Impact factor: 4.677
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