Xuan Zeng1, Yang Bai1, Wei Peng1, Weiwei Su2. 1. State Key Laboratory of Biocontrol, Guangdong Key Laboratory of Plant Resources, Guangdong Engineering & Technology Research Center for Quality and Efficacy Re-evaluation of Post-market Traditional Chinese Medicine, School of Life Sciences, Sun Yat-sen University, No. 135, Xingang Xi Road, Guangzhou, 510275, People's Republic of China. 2. State Key Laboratory of Biocontrol, Guangdong Key Laboratory of Plant Resources, Guangdong Engineering & Technology Research Center for Quality and Efficacy Re-evaluation of Post-market Traditional Chinese Medicine, School of Life Sciences, Sun Yat-sen University, No. 135, Xingang Xi Road, Guangzhou, 510275, People's Republic of China. lsssww@126.com.
Abstract
BACKGROUND AND OBJECTIVES: Naringin, an active flavanone glycoside, has been widely considered as a prospective antitussive and expectorant. The present study aimed to elucidate the metabolic profile of naringin in the human body. METHODS: Four male and three female volunteers (20-30 years old and 18.8-21.7 kg/m2 Body Mass Index) were orally administrated 320 mg naringin; their urine and feces were collected at different times and the corresponding metabolites were identified with a high resolution ultra-fast liquid chromatography-quadrupole-time-of-flight tandem mass spectrometry (UFLC-Q-TOF-MS/MS) system. RESULTS: Sixteen conjugative metabolites and five polyphenols were identified. These detected metabolites varied in the types, relative responses, and excretion times among different individuals. CONCLUSIONS: The results revealed that naringin underwent extensive phase II metabolism in the human body and yielded an array of conjugated products. This study provided a reference for further clinical studies and in vivo metabolism of other flavonoids.
BACKGROUND AND OBJECTIVES:Naringin, an active flavanone glycoside, has been widely considered as a prospective antitussive and expectorant. The present study aimed to elucidate the metabolic profile of naringin in the human body. METHODS: Four male and three female volunteers (20-30 years old and 18.8-21.7 kg/m2 Body Mass Index) were orally administrated 320 mg naringin; their urine and feces were collected at different times and the corresponding metabolites were identified with a high resolution ultra-fast liquid chromatography-quadrupole-time-of-flight tandem mass spectrometry (UFLC-Q-TOF-MS/MS) system. RESULTS: Sixteen conjugative metabolites and five polyphenols were identified. These detected metabolites varied in the types, relative responses, and excretion times among different individuals. CONCLUSIONS: The results revealed that naringin underwent extensive phase II metabolism in the human body and yielded an array of conjugated products. This study provided a reference for further clinical studies and in vivo metabolism of other flavonoids.
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