Literature DB >> 2774416

Expression of mouse protamine 1 genes in transgenic mice.

J J Peschon1, R R Behringer, R D Palmiter, R L Brinster.   

Abstract

Mouse protamine genes are expressed exclusively in spermatids. Mouse protamine 1 (mP1) transcriptional regulatory elements can target the expression of either marked mP1 transgenes or mP1 chimeric genes to spermatids in transgenic mice. Sequences between -40 and -465 bp relative to the transcription start site are required for expression in spermatids, whereas sequences 3' of the point of translation initiation are dispensable. mP1 transcriptional regulatory sequences were used to direct the expression of a toxic gene product to spermatids. The phenotypic consequences of toxin expression in spermatids are described.

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Year:  1989        PMID： 2774416     DOI： 10.1111/j.1749-6632.1989.tb25897.x

Source DB:  PubMed          Journal:  Ann N Y Acad Sci        ISSN： 0077-8923            Impact factor:   5.691


  6 in total

1.  Factors involved in regulation of the RT7 promoter in a male germ cell-derived in vitro transcription system.

Authors:  F A van der Hoorn; H A Tarnasky
Journal:  Proc Natl Acad Sci U S A       Date:  1992-01-15       Impact factor: 11.205

2.  Large-scale analysis of the regulatory architecture of the mouse genome with a transposon-associated sensor.

Authors:  Sandra Ruf; Orsolya Symmons; Veli Vural Uslu; Dirk Dolle; Chloé Hot; Laurence Ettwiller; François Spitz
Journal:  Nat Genet       Date:  2011-03-20       Impact factor: 38.330

3.  Protamine-Cre recombinase transgenes efficiently recombine target sequences in the male germ line of mice, but not in embryonic stem cells.

Authors:  S O'Gorman; N A Dagenais; M Qian; Y Marchuk
Journal:  Proc Natl Acad Sci U S A       Date:  1997-12-23       Impact factor: 11.205

Review 4.  Lessons from knockout and transgenic mice for infertility in men.

Authors:  J P Venables; H J Cooke
Journal:  J Endocrinol Invest       Date:  2000-10       Impact factor: 4.256

5.  Illegitimate Cre-dependent chromosome rearrangements in transgenic mouse spermatids.

Authors:  E E Schmidt; D S Taylor; J R Prigge; S Barnett; M R Capecchi
Journal:  Proc Natl Acad Sci U S A       Date:  2000-12-05       Impact factor: 11.205

6.  Analysis of the mouse protamine 1 promoter in transgenic mice.

Authors:  B P Zambrowicz; C J Harendza; J W Zimmermann; R L Brinster; R D Palmiter
Journal:  Proc Natl Acad Sci U S A       Date:  1993-06-01       Impact factor: 11.205
  6 in total

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