Eric Vigneault1, Khaly Mbodji2, Louis-Gabriel Racine3, Eric Chevrette3, Marie-Claude Lavallée4, André-Guy Martin5, Philippe Després6, Luc Beaulieu6. 1. Département de radio-oncologie, CHU de Québec-Université Laval, Québec, Québec, Canada; Centre de recherche du CHU de Québec, Québec, Québec, Canada; Centre de recherche sur le cancer de l'Université Laval, Québec, Québec, Canada. Electronic address: eric.vigneault@mail.chudequebec.ca. 2. Département de radio-oncologie, CHU de Québec-Université Laval, Québec, Québec, Canada; Centre de recherche du CHU de Québec, Québec, Québec, Canada. 3. Département de d'imagerie médicale, CHU de Québec-Université Laval, Québec, Québec, Canada. 4. Département de radio-oncologie, CHU de Québec-Université Laval, Québec, Québec, Canada. 5. Département de radio-oncologie, CHU de Québec-Université Laval, Québec, Québec, Canada; Centre de recherche du CHU de Québec, Québec, Québec, Canada; Centre de recherche sur le cancer de l'Université Laval, Québec, Québec, Canada. 6. Département de radio-oncologie, CHU de Québec-Université Laval, Québec, Québec, Canada; Centre de recherche du CHU de Québec, Québec, Québec, Canada; Centre de recherche sur le cancer de l'Université Laval, Québec, Québec, Canada; Département de physique, de génie physique et d'optique, Université Laval, Québec, Québec, Canada.
Abstract
PURPOSE: To evaluate the long-term outcomes of image-guided high-dose-rate (HDR) brachytherapy boost to the dominant intraprostatic lesion (DIL) using multiparametric magnetic resonance imaging (MRI), including spectroscopy (MRI/magnetic resonance spectroscopy [MRS]). METHODS AND MATERIALS: Between December 2009 and March 2011, 20 patients with intermediate-risk prostate cancer underwent multiparametric MRI/MRS protocol before treatment. All patients were treated with an external beam radiotherapy dose of 40 Gy, combined with an HDR brachytherapy boost of 15 Gy. Concurrently, the DIL received a boost of 18 Gy. Missing data during followup were handled with multiple imputations. RESULTS: The median followup was 62 months (range, 23-71 months). Six patients (31%) were classified as favorable intermediate risk and 13 patients (69%) as unfavorable intermediate risk. One patient experienced a prostate-specific antigen biochemical failure, and the 5-year biochemical failure-free survival rate was of 94.7%. The mean International Prostate Symptom Score rose from 7, with respect to baseline, to 10.42 1 month after treatment, and rapidly decreased to 6.97 after 3 months. Grade 1, 2, and 3 acute genitourinary toxicities were reported in 13 (68%), 3 (16%), and 1 (5%) patients, respectively. Grade 1 and 2 late genitourinary toxicities were reported in 9 (53%) and 3 (18%) patients, respectively. Only grade 1 acute and late gastrointestinal toxicities were reported in 4 (21%) and 3 (18%) patients, respectively. CONCLUSIONS: Delivering an HDR brachytherapy boost to the DIL using image-guided multiparametric MRI/MRS is feasible with good outcomes for biochemical control, acute and late toxicities, and dosimetric constraints for critical organs. Copyright Â
PURPOSE: To evaluate the long-term outcomes of image-guided high-dose-rate (HDR) brachytherapy boost to the dominant intraprostatic lesion (DIL) using multiparametric magnetic resonance imaging (MRI), including spectroscopy (MRI/magnetic resonance spectroscopy [MRS]). METHODS AND MATERIALS: Between December 2009 and March 2011, 20 patients with intermediate-risk prostate cancer underwent multiparametric MRI/MRS protocol before treatment. All patients were treated with an external beam radiotherapy dose of 40 Gy, combined with an HDR brachytherapy boost of 15 Gy. Concurrently, the DIL received a boost of 18 Gy. Missing data during followup were handled with multiple imputations. RESULTS: The median followup was 62 months (range, 23-71 months). Six patients (31%) were classified as favorable intermediate risk and 13 patients (69%) as unfavorable intermediate risk. One patient experienced a prostate-specific antigen biochemical failure, and the 5-year biochemical failure-free survival rate was of 94.7%. The mean International Prostate Symptom Score rose from 7, with respect to baseline, to 10.42 1 month after treatment, and rapidly decreased to 6.97 after 3 months. Grade 1, 2, and 3 acute genitourinary toxicities were reported in 13 (68%), 3 (16%), and 1 (5%) patients, respectively. Grade 1 and 2 late genitourinary toxicities were reported in 9 (53%) and 3 (18%) patients, respectively. Only grade 1 acute and late gastrointestinal toxicities were reported in 4 (21%) and 3 (18%) patients, respectively. CONCLUSIONS: Delivering an HDR brachytherapy boost to the DIL using image-guided multiparametric MRI/MRS is feasible with good outcomes for biochemical control, acute and late toxicities, and dosimetric constraints for critical organs. Copyright Â
Authors: I-Chow Hsu; Joseph P Rodgers; Katsuto Shinohara; James Purdy; Jeff Michalski; Mack Roach; Eric Vigneault; Robert A Ivker; Rodger M Pryzant; Michael Kuettel; Daniel Taussky; Gary S Gustafson; Adam Raben; Howard M Sandler Journal: Int J Radiat Oncol Biol Phys Date: 2020-11-10 Impact factor: 8.013
Authors: Christopher W Smith; Ryan Alfano; Douglas Hoover; Kathleen Surry; David D'Souza; Jonathan Thiessen; Irina Rachinsky; John Butler; Jose A Gomez; Mena Gaed; Madeleine Moussa; Joseph Chin; Stephen Pautler; Glenn S Bauman; Aaron D Ward Journal: Phys Imaging Radiat Oncol Date: 2021-07-30
Authors: Christopher H Chapman; Steve E Braunstein; Jean Pouliot; Susan M Noworolski; Vivian Weinberg; Adam Cunha; John Kurhanewicz; Alexander R Gottschalk; Mack Iii Roach; I-Chow Hsu Journal: J Contemp Brachytherapy Date: 2018-06-29
Authors: Kevin Martell; Soumyajit Roy; Tyler Meyer; Jordan Stosky; Will Jiang; Kundan Thind; Michael Roumeliotis; John Bosch; Steve Angyalfi; Harvey Quon; Siraj Husain Journal: Heliyon Date: 2020-06-07