Literature DB >> 27742668

Effects of Exercise on Insulin, IGF Axis, Adipocytokines, and Inflammatory Markers in Breast Cancer Survivors: A Systematic Review and Meta-analysis.

Dong-Woo Kang1, Junga Lee2,3, Sang-Hoon Suh4, Jennifer Ligibel5, Kerry S Courneya1, Justin Y Jeon6,3,7.   

Abstract

Background: Insulin, IGF axis, adiponectin, and inflammatory markers are associated with breast cancer. Given that physical activity improves prognosis of breast cancer survivors, we investigated the effects of exercise on these markers as potential mediators between physical activity and breast cancer.
Methods: PubMed, EMBASE, CENTRAL, CINAHL, and SportDiscus were searched up to December 3, 2015, to identify randomized controlled trials (RCT) that investigated the effect of exercise on insulin, IGF axis, and cytokines in breast cancer survivors. Weighted mean difference (WMD) was calculated using either fixed- or random-effects models on the basis of the heterogeneity of the studies.
Results: A total of 18 studies involving 681 breast cancer survivors were included, and these numbers were reduced for individual biomarker analyses. We found that exercise significantly reduced fasting insulin levels [WMD, -3.46 μU/mL; 95% confidence interval (CI), -5.97 to -0.95; P = 0.007]. Furthermore, potentially meaningful but statistically nonsignificant changes were observed in insulin resistance (WMD, -0.73; 95% CI, -0.54 to 0.13; P = 0.23), adiponectin (WMD, 1.17 μg/mL; 95% CI, -0.87 to 3.20; P = 0.26), and C-reactive protein (WMD, -1.10 mg/L; 95% CI, -2.39 to 0.20; P = 0.10). Subgroup analyses showed that fasting insulin levels were significantly more impacted in studies in which intervention participants experienced a weight reduction (WMD, -7.10 μU/mL; 95% CI, -10.31 to -3.90; P < 0.001).Conclusions: Exercise reduces fasting insulin levels in breast cancer survivors. This may be due to exercise-induced reductions in body weight.Impact: Practitioners and clinicians may better help breast cancer prognosis be improved through exercise, anticipating physiological effects on cancer. Cancer Epidemiol Biomarkers Prev; 26(3); 355-65. ©2016 AACR. ©2016 American Association for Cancer Research.

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Year:  2016        PMID： 27742668     DOI： 10.1158/1055-9965.EPI-16-0602

Source DB:  PubMed          Journal:  Cancer Epidemiol Biomarkers Prev        ISSN： 1055-9965            Impact factor:   4.254


  30 in total

1.  Physical Activity, Weight Control, and Biomarkers of Prognosis and Survival among Breast Cancer Survivors.

Authors:  Steven Scott Coughlin; Gaston Kapuku
Journal:  Arch Epidemiol       Date:  2018-12-26

2.  The Effects of Resistance Exercise on Biomarkers of Breast Cancer Prognosis: A Pooled Analysis of Three Randomized Trials.

Authors:  Kerri M Winters-Stone; Lisa J Wood; Sydnee Stoyles; Nathan F Dieckmann
Journal:  Cancer Epidemiol Biomarkers Prev       Date:  2017-11-15       Impact factor: 4.254

3.  Insulin Resistance and Cancer-Specific and All-Cause Mortality in Postmenopausal Women: The Women's Health Initiative.

Authors:  Kathy Pan; Rebecca A Nelson; Jean Wactawski-Wende; Delphine J Lee; JoAnn E Manson; Aaron K Aragaki; Joanne E Mortimer; Lawrence S Phillips; Thomas Rohan; Gloria Y F Ho; Nazmus Saquib; Aladdin H Shadyab; Rami Nassir; Jinnie J Rhee; Arti Hurria; Rowan T Chlebowski
Journal:  J Natl Cancer Inst       Date:  2020-02-01       Impact factor: 13.506

4.  Adipose tissue inflammation in breast cancer survivors: effects of a 16-week combined aerobic and resistance exercise training intervention.

Authors:  Christina M Dieli-Conwright; Jean-Hugues Parmentier; Nathalie Sami; Kyuwan Lee; Darcy Spicer; Wendy J Mack; Fred Sattler; Steven D Mittelman
Journal:  Breast Cancer Res Treat       Date:  2017-11-22       Impact factor: 4.872

5.  Continuous, objective measurement of physical activity during chemotherapy for breast cancer: the Activity in Treatment pilot study.

Authors:  Sandahl H Nelson; Lauren S Weiner; Loki Natarajan; Barbara A Parker; Ruth E Patterson; Sheri J Hartman
Journal:  Transl Behav Med       Date:  2020-10-08       Impact factor: 3.046

6.  Association of type and intensity of physical activity with plasma biomarkers of inflammation and insulin response.

Authors:  Dong Hoon Lee; Leandro Fórnias Machado de Rezende; José Eluf-Neto; Kana Wu; Fred K Tabung; Edward L Giovannucci
Journal:  Int J Cancer       Date:  2019-01-24       Impact factor: 7.396

7.  Kernel Density Estimation as a Measure of Environmental Exposure Related to Insulin Resistance in Breast Cancer Survivors.

Authors:  Marta M Jankowska; Loki Natarajan; Suneeta Godbole; Kristin Meseck; Dorothy D Sears; Ruth E Patterson; Jacqueline Kerr
Journal:  Cancer Epidemiol Biomarkers Prev       Date:  2017-03-03       Impact factor: 4.254

8.  Involvement of IGF/IGFBP/Erk axis in the exercise-mediated preventive effects on colorectal cancer in rats.

Authors:  Saber Ghazizadeh Darband; Shirin Sadighparvar; Firouz Ghaderi Pakdel; Somayeh Naderi; Maryam Majidinia
Journal:  Int J Clin Exp Pathol       Date:  2021-05-15

9.  Effects of Aerobic and Resistance Exercise on Metabolic Syndrome, Sarcopenic Obesity, and Circulating Biomarkers in Overweight or Obese Survivors of Breast Cancer: A Randomized Controlled Trial.

Authors:  Christina M Dieli-Conwright; Kerry S Courneya; Wendy Demark-Wahnefried; Nathalie Sami; Kyuwan Lee; Thomas A Buchanan; Darcy V Spicer; Debu Tripathy; Leslie Bernstein; Joanne E Mortimer
Journal:  J Clin Oncol       Date:  2018-01-22       Impact factor: 44.544

10.  Effects of Diet and Exercise-Induced Weight Loss on Biomarkers of Inflammation in Breast Cancer Survivors: A Systematic Review and Meta-analysis.

Authors:  Tyler J Bruinsma; Anne-Marie Dyer; Connie J Rogers; Kathryn H Schmitz; Kathleen M Sturgeon
Journal:  Cancer Epidemiol Biomarkers Prev       Date:  2021-03-18       Impact factor: 4.254
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