| Literature DB >> 27742538 |
Jiaojiao Pang1, Jiali Wang2, Yingmei Zhang3, Feng Xu4, Yuguo Chen5.
Abstract
Heart failure is one of the major causes of the ever-rising mortality globally. ALDH2 rs671 polymorphism is proven to be closely related to the prevalence of CAD, hypertension, diabetes mellitus and alcoholism, which are etiological factors of heart failure. In addition, growing evidence supports a possible role for ALDH2 in different forms of heart failure. In this mini-review, we will review the recent insights regarding the effects of ALDH2 polymorphism on etiological factors of heart failure and underlying mechanisms involved. In addition, we will also discuss the booming epigenetic information in this field which will greatly improve our understanding of the cardiovascular effect of ALDH2. This article is part of a Special Issue entitled: Genetic and epigenetic control of heart failure edited by Dr. Jun Ren & Yingmei Zhang.Entities:
Keywords: ALDH2; Epigenetic regulation; Genetic polymorphism; Heart failure
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Year: 2016 PMID： 27742538 DOI： 10.1016/j.bbadis.2016.10.004
Source DB: PubMed Journal: Biochim Biophys Acta Mol Basis Dis ISSN： 0925-4439 Impact factor: 5.187