Literature DB >> 27742195

Mitochondrial dysfunction in obesity-related kidney disease: a novel therapeutic target.

Chengyuan Tang1, Juan Cai1, Zheng Dong2.   

Abstract

Lipid accumulation in renal cells has been implicated in the pathogenesis of obesity-related kidney disease, but the underlying mechanism is poorly understood. Szeto et al. now unravel a central role of mitochondrial dysfunction in a high fat diet-induced glomerulopathy and proximal tubular injury. Moreover, they demonstrate the renoprotective effect of SS31, a mitochondria-targeted antioxidant, in related models. Targeting mitochondria may offer a novel strategy for the therapy of obesity-related kidney disease. Published by Elsevier Inc.

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Year:  2016        PMID： 27742195     DOI： 10.1016/j.kint.2016.07.045

Source DB:  PubMed          Journal:  Kidney Int        ISSN： 0085-2538            Impact factor:   10.612


  10 in total

Review 1.  Obesity-related glomerulopathy: pathogenesis, pathologic, clinical characteristics and treatment.

Authors:  Tianhua Xu; Zitong Sheng; Li Yao
Journal:  Front Med       Date:  2017-08-08       Impact factor: 4.592

Review 2.  Bariatric surgery and kidney disease outcomes in severely obese youth.

Authors:  Petter Bjornstad; Edward Nehus; Daniel van Raalte
Journal:  Semin Pediatr Surg       Date:  2020-01-20       Impact factor: 2.754

3.  Synthesis, Characterization, and Specific Localization of Mitochondrial-Targeted Antioxidant Peptide SS31 Probe.

Authors:  Yuan He; Ruixue Zhang; Zhuoya Quan; Beilei He; Yun Xu; Zejun Chen; Yuan Ren; Xu Liu
Journal:  Biomed Res Int       Date:  2021-05-19       Impact factor: 3.411

4.  Nifedipine Exacerbates Lipogenesis in the Kidney via KIM-1, CD36, and SREBP Upregulation: Implications from an Animal Model for Human Study.

Authors:  Yen-Chung Lin; Jhih-Cheng Wang; Mai-Szu Wu; Yuh-Feng Lin; Chang-Rong Chen; Chang-Yu Chen; Kuan-Chou Chen; Chiung-Chi Peng
Journal:  Int J Mol Sci       Date:  2020-06-19       Impact factor: 5.923

Review 5.  Pleiotropic Effects of Sodium-Glucose Cotransporter-2 Inhibitors: Renoprotective Mechanisms beyond Glycemic Control.

Authors:  Tomoaki Takata; Hajime Isomoto
Journal:  Int J Mol Sci       Date:  2021-04-22       Impact factor: 5.923

6.  IκB kinase promotes Nrf2 ubiquitination and degradation by phosphorylating cylindromatosis, aggravating oxidative stress injury in obesity-related nephropathy.

Authors:  Yin-Yin Chen; Han Hong; Yu-Ting Lei; Jia Zou; Yi-Ya Yang; Li-Yu He
Journal:  Mol Med       Date:  2021-10-28       Impact factor: 6.354

Review 7.  The NLPR3 inflammasome and obesity-related kidney disease.

Authors:  Ben Ke; Wen Shen; Xiangdong Fang; Qinghua Wu
Journal:  J Cell Mol Med       Date:  2017-08-31       Impact factor: 5.310

8.  Aloe Emodin Reduces Cardiac Inflammation Induced by a High-Fat Diet through the TLR4 Signaling Pathway.

Authors:  Yingfu Chen; Burong Feng; Ye Yuan; Juan Hu; Wei Zhao; Huiwei Jiang; Wen Li; Ziyi Fan; Zhimin Du
Journal:  Mediators Inflamm       Date:  2020-02-05       Impact factor: 4.711

Review 9.  Critical Role for AMPK in Metabolic Disease-Induced Chronic Kidney Disease.

Authors:  Florian Juszczak; Nathalie Caron; Anna V Mathew; Anne-Emilie Declèves
Journal:  Int J Mol Sci       Date:  2020-10-27       Impact factor: 5.923

10.  Melatonin Improves Mitochondrial Dynamics and Function in the Kidney of Zücker Diabetic Fatty Rats.

Authors:  Ahmad Agil; Meriem Chayah; Lucia Visiedo; Miguel Navarro-Alarcon; José Manuel Rodríguez Ferrer; Mohamed Tassi; Russel J Reiter; Gumersindo Fernández-Vázquez
Journal:  J Clin Med       Date:  2020-09-10       Impact factor: 4.241
  10 in total

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