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Literature DB >> 27741405

Transgenic Mouse Models of Tumor Virus Action.

Abstract

Genetically engineered mice (GEMs) have provided valuable insights into the carcinogenic properties of various human tumor viruses, which, in aggregate, are etiologically associated with over 15% of all human cancers. This review provides an overview of seminal discoveries made through the use of GEM models for human DNA tumor viruses. Emphasis is placed on the discoveries made in the study of human papillomaviruses, Merkel cell carcinoma-associated polyomavirus, Epstein-Barr virus, and Kaposi's sarcoma-associated herpesvirus, because GEMs have contributed extensively to our understanding of how these DNA tumor viruses directly contribute to human cancers.

Entities: Disease Species

Keywords: EBV; GEM; HPV; KSHV; MCPyV; cancer; in vivo; transgenic

Mesh：

Year: 2016 PMID： 27741405 DOI： 10.1146/annurev-virology-100114-054908

Source DB: PubMed Journal: Annu Rev Virol ISSN： 2327-056X Impact factor: 10.431

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Cited

12 in total

1. Development of an in vivo infection model to study Mouse papillomavirus-1 (MmuPV1).

Authors: Aayushi Uberoi; Satoshi Yoshida; Paul F Lambert
Journal: J Virol Methods Date: 2017-12-15 Impact factor: 2.014

2. Cooperation of genes in HPV16 E6/E7-dependent cervicovaginal carcinogenesis trackable by endoscopy and independent of exogenous estrogens or carcinogens.

Authors: Paula Böttinger; Karin Schreiber; Elizabeth Hyjek; Thomas Krausz; Michael T Spiotto; Madeline Steiner; Christian Idel; Heather Booras; Gabriele Beck-Engeser; Jessie Riederer; Gerald Willimsky; Steven P Wolf; Theodore Karrison; Elizabeth Jensen; Ralph R Weichselbaum; Yusuke Nakamura; Poh Yin Yew; Paul F Lambert; Takeshi Kurita; Kazuma Kiyotani; Matthias Leisegang; Hans Schreiber
Journal: Carcinogenesis Date: 2020-11-13 Impact factor: 4.944

Review 3. Human Papillomavirus and the Stroma: Bidirectional Crosstalk during the Virus Life Cycle and Carcinogenesis.

Authors: Megan E Spurgeon; Paul F Lambert
Journal: Viruses Date: 2017-08-09 Impact factor: 5.048

Review 4. Murine HPV16 E7-expressing transgenic skin effectively emulates the cellular and molecular features of human high-grade squamous intraepithelial lesions.

Authors: Z K Tuong; K Noske; P Kuo; A A Bashaw; S M Teoh; I H Frazer
Journal: Papillomavirus Res Date: 2017-10-19

5. A Mouse Model of Oropharyngeal Papillomavirus-Induced Neoplasia Using Novel Tools for Infection and Nasal Anesthesia.

Authors: Andrea Bilger; Renee E King; Josh P Schroeder; Jared T Piette; Louis A Hinshaw; Andrew D Kurth; Ronnie W AlRamahi; Matthew V Barthel; Ella T Ward-Shaw; Darya Buehler; Kristyn S Masters; Susan L Thibeault; Paul F Lambert
Journal: Viruses Date: 2020-04-16 Impact factor: 5.048

6. An Immunocompetent Mouse Model of HPV16(+) Head and Neck Squamous Cell Carcinoma.

Authors: Miranda B Carper; Scott Troutman; Bethany L Wagner; Kevin M Byrd; Sara R Selitsky; Kshitij Parag-Sharma; Erin C Henry; Weimin Li; Joel S Parker; Stephanie A Montgomery; John L Cleveland; Scott E Williams; Joseph L Kissil; David N Hayes; Antonio L Amelio
Journal: Cell Rep Date: 2019-11-05 Impact factor: 9.423

Transgenic Mouse Models of Tumor Virus Action.

1. Development of an in vivo infection model to study Mouse papillomavirus-1 (MmuPV1).

2. Cooperation of genes in HPV16 E6/E7-dependent cervicovaginal carcinogenesis trackable by endoscopy and independent of exogenous estrogens or carcinogens.

Review 3. Human Papillomavirus and the Stroma: Bidirectional Crosstalk during the Virus Life Cycle and Carcinogenesis.

Review 4. Murine HPV16 E7-expressing transgenic skin effectively emulates the cellular and molecular features of human high-grade squamous intraepithelial lesions.

5. A Mouse Model of Oropharyngeal Papillomavirus-Induced Neoplasia Using Novel Tools for Infection and Nasal Anesthesia.

6. An Immunocompetent Mouse Model of HPV16(+) Head and Neck Squamous Cell Carcinoma.

Review 7. Mus musculus Papillomavirus 1: a New Frontier in Animal Models of Papillomavirus Pathogenesis.

8. Role of IQGAP1 in Papillomavirus-Associated Head and Neck Tumorigenesis.

9. Terc is dispensable for most of the short-term HPV16 oncogene-mediated phenotypes in mice.

Review 10. Cutaneous Papillomaviruses and Non-melanoma Skin Cancer: Causal Agents or Innocent Bystanders?