Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 Calcium signalling and ER stress in insulin resistance and atherosclerosis.

Literature DB >> 27739133

Calcium signalling and ER stress in insulin resistance and atherosclerosis.

Abstract

The burden of type 2 diabetes and its major complication cardiovascular disease is rapidly increasing worldwide. Understanding the underlying pathogenic mechanisms of these diseases is crucial to develop novel therapeutics. Recent work using genetic and biochemical methods in mouse models and human samples have identified disturbed calcium signalling and endoplasmic reticulum stress as emerging factors involved in the pathogenesis of many metabolic diseases. In this review, we will highlight the specific roles of calcium signalling and endoplasmic reticulum stress response in the development of insulin resistance and atherosclerosis.

Entities: Chemical Disease Gene Mutation Species

Keywords: atherosclerosis; calcium; diabetes mellitus; insulin resistance; metabolic syndrome

Mesh：

Year: 2016 PMID： 27739133 PMCID： PMC5083967 DOI： 10.1111/joim.12562

Source DB: PubMed Journal: J Intern Med ISSN： 0954-6820 Impact factor: 8.989

76 in total

1. Activation of calcium/calmodulin-dependent protein kinase II in obesity mediates suppression of hepatic insulin signaling.

Authors: Lale Ozcan; Jane Cristina de Souza; Alp Avi Harari; Johannes Backs; Eric N Olson; Ira Tabas
Journal: Cell Metab Date: 2013-11-21 Impact factor: 27.287

2. Phagocytosis of apoptotic cells by macrophages is impaired in atherosclerosis.

Authors: Dorien M Schrijvers; Guido R Y De Meyer; Mark M Kockx; Arnold G Herman; Wim Martinet
Journal: Arterioscler Thromb Vasc Biol Date: 2005-04-14 Impact factor: 8.311

3. Calcium signaling through CaMKII regulates hepatic glucose production in fasting and obesity.

Authors: Lale Ozcan; Catherine C L Wong; Gang Li; Tao Xu; Utpal Pajvani; Sung Kyu Robin Park; Anetta Wronska; Bi-Xing Chen; Andrew R Marks; Akiyoshi Fukamizu; Johannes Backs; Harold A Singer; John R Yates; Domenico Accili; Ira Tabas
Journal: Cell Metab Date: 2012-04-12 Impact factor: 27.287

4. The endoplasmic reticulum chaperone improves insulin resistance in type 2 diabetes.

Authors: Kentaro Ozawa; Mayuki Miyazaki; Munehide Matsuhisa; Katsura Takano; Yoshihisa Nakatani; Masahiro Hatazaki; Takashi Tamatani; Kazuya Yamagata; Jun-Ichiro Miyagawa; Yasuko Kitao; Osamu Hori; Yoshimitsu Yamasaki; Satoshi Ogawa
Journal: Diabetes Date: 2005-03 Impact factor: 9.461

5. The endoplasmic reticulum stress-C/EBP homologous protein pathway-mediated apoptosis in macrophages contributes to the instability of atherosclerotic plaques.

Authors: Hiroto Tsukano; Tomomi Gotoh; Motoyoshi Endo; Keishi Miyata; Hirokazu Tazume; Tsuyoshi Kadomatsu; Masato Yano; Takao Iwawaki; Kenji Kohno; Kimi Araki; Hiroshi Mizuta; Yuichi Oike
Journal: Arterioscler Thromb Vasc Biol Date: 2010-07-22 Impact factor: 8.311

6. Dual and opposing roles of the unfolded protein response regulated by IRE1alpha and XBP1 in proinsulin processing and insulin secretion.

Authors: Ann-Hwee Lee; Keely Heidtman; Gökhan S Hotamisligil; Laurie H Glimcher
Journal: Proc Natl Acad Sci U S A Date: 2011-05-09 Impact factor: 11.205

Review 7. Intracellular calcium release and cardiac disease.

Authors: Xander H T Wehrens; Stephan E Lehnart; Andrew R Marks
Journal: Annu Rev Physiol Date: 2005 Impact factor: 19.318

8. Inositol-1,4,5-trisphosphate receptor regulates hepatic gluconeogenesis in fasting and diabetes.

Authors: Yiguo Wang; Gang Li; Jason Goode; Jose C Paz; Kunfu Ouyang; Robert Screaton; Wolfgang H Fischer; Ju Chen; Ira Tabas; Marc Montminy
Journal: Nature Date: 2012-04-08 Impact factor: 49.962

9. Proteomics analysis of human obesity reveals the epigenetic factor HDAC4 as a potential target for obesity.

Authors: Mohamed Abu-Farha; Ali Tiss; Jehad Abubaker; Abdelkrim Khadir; Fahad Al-Ghimlas; Irina Al-Khairi; Engin Baturcam; Preethi Cherian; Naser Elkum; Maha Hammad; Jeena John; Sina Kavalakatt; Samia Warsame; Kazem Behbehani; Said Dermime; Mohammed Dehbi
Journal: PLoS One Date: 2013-09-24 Impact factor: 3.240

10. Reducing endoplasmic reticulum stress through a macrophage lipid chaperone alleviates atherosclerosis.

Authors: Ebru Erbay; Vladimir R Babaev; Jared R Mayers; Liza Makowski; Khanichi N Charles; Melinda E Snitow; Sergio Fazio; Michelle M Wiest; Steven M Watkins; Macrae F Linton; Gökhan S Hotamisligil
Journal: Nat Med Date: 2009-11-29 Impact factor: 53.440

15 in total

Review 10. Crosstalk Between the Unfolded Protein Response, MicroRNAs, and Insulin Signaling Pathways: In Search of Biomarkers for the Diagnosis and Treatment of Type 2 Diabetes.

Authors: Chinar Berry; Megha Lal; B K Binukumar
Journal: Front Endocrinol (Lausanne) Date: 2018-05-02 Impact factor: 5.555

Calcium signalling and ER stress in insulin resistance and atherosclerosis.

1. Activation of calcium/calmodulin-dependent protein kinase II in obesity mediates suppression of hepatic insulin signaling.

2. Phagocytosis of apoptotic cells by macrophages is impaired in atherosclerosis.

3. Calcium signaling through CaMKII regulates hepatic glucose production in fasting and obesity.

4. The endoplasmic reticulum chaperone improves insulin resistance in type 2 diabetes.

5. The endoplasmic reticulum stress-C/EBP homologous protein pathway-mediated apoptosis in macrophages contributes to the instability of atherosclerotic plaques.

6. Dual and opposing roles of the unfolded protein response regulated by IRE1alpha and XBP1 in proinsulin processing and insulin secretion.

Review 7. Intracellular calcium release and cardiac disease.

8. Inositol-1,4,5-trisphosphate receptor regulates hepatic gluconeogenesis in fasting and diabetes.

9. Proteomics analysis of human obesity reveals the epigenetic factor HDAC4 as a potential target for obesity.

10. Reducing endoplasmic reticulum stress through a macrophage lipid chaperone alleviates atherosclerosis.

Review 1. SERCA control of cell death and survival.

2. Activation of the Integrated Stress Response and Metabolic Dysfunction in a Murine Model of Sleep Apnea.

Review 3. The Mystery of Exosomes in Gestational Diabetes Mellitus.

4. Mechanism by which arylamine N-acetyltransferase 1 ablation causes insulin resistance in mice.

Review 5. Role of Minerals and Trace Elements in Diabetes and Insulin Resistance.

Review 6. ER Stress Activates the NLRP3 Inflammasome: A Novel Mechanism of Atherosclerosis.

7. Serum Elemental Analysis of Type 2 Diabetes Patients Using SRXRF.

8. Defective STIM-mediated store operated Ca²⁺ entry in hepatocytes leads to metabolic dysfunction in obesity.

9. Inhibition of endoplasmic reticulum stress alleviates cigarette smoke-induced airway inflammation and emphysema.

Review 10. Crosstalk Between the Unfolded Protein Response, MicroRNAs, and Insulin Signaling Pathways: In Search of Biomarkers for the Diagnosis and Treatment of Type 2 Diabetes.