Mulalibieke Heizhati1, Nanfang Li2, Liang Shao1, Xiaoguang Yao1, Yingchun Wang1, Jing Hong1, Ling Zhou1, Delian Zhang1, Guijuan Chang1, Suofeiya Abulikemu1. 1. The Center of Hypertension of the People's Hospital of Xinjiang Uygur Autonomous Region; The Center of Diagnosis, Treatment and Research of Hypertension in Xinjiang, No. 91 Tianchi Road, Tianshan District Urumqi, Xinjiang, 830001, China. 2. The Center of Hypertension of the People's Hospital of Xinjiang Uygur Autonomous Region; The Center of Diagnosis, Treatment and Research of Hypertension in Xinjiang, No. 91 Tianchi Road, Tianshan District Urumqi, Xinjiang, 830001, China. lnanfang2010@sina.com.
Abstract
PURPOSE: Sleep architecture can be affected by alteration in circulating lipopolysaccaride and cytokines. However, still unknown are the effects of lipopolysaccaride-binding protein (LBP) on sleep architecture. Therefore, potential relationship between alteration in serum LBP concentrations and sleep architecture was analyzed. METHODS: This is a cross-sectional study. Consecutive 54 hypertensive males, aged 30-65 years. and with no obstructive sleep apnea via polysomnography, were recruited. Subjects were divided into two groups via the LBP median as hypertensives with higher and lower serum LBP (n = 27 and n = 27, respectively). Sleep architecture was assessed by polysomnography. Serum LBP, IL-1β, IL-6, and TNF-α were measured by commercial laboratories using sandwich-type enzyme immunoassay kit. RESULTS: Hypertensive subjects with higher LBP showed significantly higher inflammatory status as assessed by IL-1β (18.85 ± 3.71 vs 16.15 ± 4.00 ng/L, P = 0.009), IL-6 (67.64 ± 11.22 vs 58.94 ± 11.32 ng/L, P = 0.004), and TNF-α (322.27 ± 59.17 vs 283.89 ± 61.87 pg/ml, P = 0.024) than did those with lower LBP. Hypertensives with higher serum LBP also exhibited prolonged N1 % (7.63 ± 3.55 vs 4.98 ± 2.90 %, P = 0.002), the transition from wakefulness to other sleep stages or follows arousal during sleep, than did those with lower LBP. A significant positive correlation was observed between serum LBP concentrations and N1 % (r = 0.378, P = 0.005) via Spearman's correlation and remained significant even after adjusting for age, apnea-hypopnea index, and body mass index. CONCLUSION: Elevation in serum concentrations of LBP might prolong N1 % in this middle-aged hypertensive males, which needs to be confirmed further.
PURPOSE: Sleep architecture can be affected by alteration in circulating lipopolysaccaride and cytokines. However, still unknown are the effects of lipopolysaccaride-binding protein (LBP) on sleep architecture. Therefore, potential relationship between alteration in serum LBP concentrations and sleep architecture was analyzed. METHODS: This is a cross-sectional study. Consecutive 54 hypertensive males, aged 30-65 years. and with no obstructive sleep apnea via polysomnography, were recruited. Subjects were divided into two groups via the LBP median as hypertensives with higher and lower serum LBP (n = 27 and n = 27, respectively). Sleep architecture was assessed by polysomnography. Serum LBP, IL-1β, IL-6, and TNF-α were measured by commercial laboratories using sandwich-type enzyme immunoassay kit. RESULTS:Hypertensive subjects with higher LBP showed significantly higher inflammatory status as assessed by IL-1β (18.85 ± 3.71 vs 16.15 ± 4.00 ng/L, P = 0.009), IL-6 (67.64 ± 11.22 vs 58.94 ± 11.32 ng/L, P = 0.004), and TNF-α (322.27 ± 59.17 vs 283.89 ± 61.87 pg/ml, P = 0.024) than did those with lower LBP. Hypertensives with higher serum LBP also exhibited prolonged N1 % (7.63 ± 3.55 vs 4.98 ± 2.90 %, P = 0.002), the transition from wakefulness to other sleep stages or follows arousal during sleep, than did those with lower LBP. A significant positive correlation was observed between serum LBP concentrations and N1 % (r = 0.378, P = 0.005) via Spearman's correlation and remained significant even after adjusting for age, apnea-hypopnea index, and body mass index. CONCLUSION: Elevation in serum concentrations of LBP might prolong N1 % in this middle-aged hypertensive males, which needs to be confirmed further.
Authors: Ritchie E Brown; Radhika Basheer; James T McKenna; Robert E Strecker; Robert W McCarley Journal: Physiol Rev Date: 2012-07 Impact factor: 37.312
Authors: Thomas Reiberger; Arnulf Ferlitsch; Berit A Payer; Mattias Mandorfer; Birgit B Heinisch; Hubert Hayden; Frank Lammert; Michael Trauner; Markus Peck-Radosavljevic; Harald Vogelsang Journal: J Hepatol Date: 2012-12-20 Impact factor: 25.083
Authors: Li Wen; Ruth E Ley; Pavel Yu Volchkov; Peter B Stranges; Lia Avanesyan; Austin C Stonebraker; Changyun Hu; F Susan Wong; Gregory L Szot; Jeffrey A Bluestone; Jeffrey I Gordon; Alexander V Chervonsky Journal: Nature Date: 2008-09-21 Impact factor: 49.962