| Literature DB >> 27737801 |
P C Paula1, J T A Oliveira1, D O B Sousa1, B G T Alves1, A F U Carvalho2, O L Franco3, I M Vasconcelos4.
Abstract
Various plant species have long been used in traditional medicine worldwide to treat diabetes. Among the plant-based compounds with hypoglycemic properties, studies on insulin-like proteins isolated from leaves, fruits and seeds are rarely reported in the relevant literature. Our research group has been investigating the presence of insulin-like proteins in Moringa oleifera, a plant species native to India, and we have obtained a leaf protein isolate and semi-purified derived fractions, as well as a seed coat protein fraction (Mo-SC), with hypoglycemic activity in chemically induced diabetic mice that have increased tolerance to orally administered glucose. Equally importantly, Mo-SC possesses insulin-like antigenic epitopes. In this context, the present review aims to highlight that prospection of insulin-like proteins in plants is of the utmost importance both for finding new drugs for the treatment of diabetes and for shedding light on the mechanisms involved in diabetes.Entities:
Keywords: Diabetes therapy; Hypoglycemic protein; Insulin-like plant protein; Moringa; Prospection
Mesh：
Substances：
Year: 2016 PMID： 27737801 DOI： 10.1016/j.nbt.2016.10.005
Source DB: PubMed Journal: N Biotechnol ISSN： 1871-6784 Impact factor: 5.079